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Learn & Share: Laser Microdissection

Laser Microdissection, also known as LMD or LCM (Laser Capture Microdissection), is a contact- and contamination-free method for isolating specific single cells or entire areas of tissue from a wide variety of tissue samples. The thickness, texture and preparation technique of the original tissue are relatively unimportant. The dissectate is then available for further molecular biological methods such as PCR, real-time PCR, proteomics and other analytical techniques. Laser microdissection is now used in a large number of research fields, e.g. neurology, cancer research, plant analysis, forensics or climate research. The method is meanwhile also applied for manipulation of cell cultures or for microengraving of coverslips.

Useful Links

LMD Software

Video Tutorials on Leica LMD Software

Publication List

LMD reference list for major application fields in life science research

Communities and Web Sources Social network for scientists Online magazine and community for molecular and cell biology researchers Resource for high-end scientific illustrations, images and animations

Search Engines and Data Bases Public resource database of images, videos, and animations of cells Bioinformatic meta search engine for genes and proteins Search interface for pubmed List of academic databases and search engines Beta of Google's search engine for scientific article abstracts

Journals Directory of open access journals The EMBO Journal CBE-Life Sciences Education – an ASCB online journal Science Nature Biweekly publication of exceptional research articles Journal of Cell Science Development The Journal of Experimental Biology DMM Disease Models & Mechanisms International Journal of Life Science Methods Collection of Journals and Proceedings in Optics and Photonics SPIE - peer-reviewed journals on applied research in optics and photonics Journal of Biophotonics International, peer-reviewed, open-access, online publication Proceedings B - the Royal Society's biological research journal International Journal for microscopists

Organizations Microscopy Society of America European Microscopy Society Royal Microscopical Society ASCB American Society of Cell Biology The company of biologists

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