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New Light Shed on the Nanodomain Organization of the Endoplasmic Reticulum (ER)

Dec 02, 2019
The endoplasmic reticulum (ER) is a continuous membrane organelle in charge of protein synthesis, lipid synthesis and detoxification. The ER structure is described in terms of smooth peripheral tubules and rough ER sheets. The family of proteins responsible for maintaining the sheet or tubule architecture include the cytoskeleton-linking membrane protein 63 (CLIMP-63) and reticulon (RTN), respectively. A detailed map of the nanodomain distribution remains challenging due to the size of the structures and their highly dynamic nature. To give an idea, the ER sheet thickness and ER tubule diameter are in the 30-100 nm range, well below the diffraction limit of confocal microscopy. Read article