Confocal microscopy has brought a major turning point for the imaging techniques in biology and medicine. In contrast to material applications, biomedical research uses, in most cases, fluorescent stains to visualize specific structures and components of biological samples. Typically, three to five different fluorochromes are used for simultaneous detection. The fluorochromes vary significantly, to match the specific requirements for the given experiment. Consequently, the excitation and emission colors also vary and call for a maximum of spectral flexibility. A series of ingenious inventions has finally lead to a fully tunable confocal microscope. The design concept leaves no spectral limitations, and is hence called the “White Confocal”. It combines a white light laser source, tunable excitation filtering, tunable beam-splitting and tunable emission-detection – with full access to the keys for all colors.