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Science Lab
Science Lab
The knowledge portal of Leica Microsystems offers scientific research and teaching material on the subjects of microscopy. The content is designed to support beginners, experienced practitioners and scientists alike in their everyday work and experiments. Explore interactive tutorials and application notes, discover the basics of microscopy as well as high-end technologies – become part of the Science Lab community and share your expertise!
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![Mouse whole-mount retina. Image courtesy of the Experimental Ophthalmology Group, University of Murcia, Spain. Mouse whole-mount retina. Image courtesy of the Experimental Ophthalmology Group, University of Murcia, Spain.](/fileadmin/_processed_/4/a/csm_Mouse_whole-mount_retina_Thundered_abe5e38481.jpg)
Fast, High Acuity Imaging and AI-assisted Analysis
The use of state-of-the-art AI systems is pushing image analysis into a new generation. Challenges like the conflict between imaging power and sample integrity are being overcome with THUNDER’s…
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![3D reconstruction of an isolated human islet 3D reconstruction of an isolated human islet](/fileadmin/_processed_/d/1/csm_THUNDER-Imager-3D-Cell-Culture_isolated-human-islet_6bcb590f44.jpg)
Create New Options for Live Cell Imaging
The use of state-of-the-art AI systems is pushing image analysis into a new generation. Challenges like the conflict between imaging power and sample integrity are being overcome with THUNDER’s…
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![Correlation of markers in the LM and the FIB image. Correlation of markers in the LM and the FIB image.](/fileadmin/_processed_/7/f/csm_Correlation_of_markers_in_the_LM_and_the_FIB_image_teaser_33ce8a2e69.jpg)
How to Target Fluorescent Structures in 3D for Cryo-FIB Milling
This article describes the major steps of the cryo-electron tomography workflow including super-resolution cryo-confocal microscopy. We describe how subcellular structures can be precisely located in…
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![Documentation of an automotive clutch friction surface with a digital microscope Documentation of an automotive clutch friction surface with a digital microscope](/fileadmin/_processed_/f/2/csm_dvm6_auto_fig_teaser_jan_2022_4cc1328338.jpg)
Verifying Specifications for Auto Parts and Components
During the development and production of automotive parts and components, whether by suppliers or the auto manufacturer, specifications must be met. This goal is important, because the specifications…
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![Plastic reconstructive surgery with M530 OHX Plastic reconstructive surgery with M530 OHX](/fileadmin/_processed_/0/8/csm_M530_plastic_reconstructive_surgery_Advances_in_Oncological_Reconstructive_Surgery_8ce367fe6b.jpg)
Advances in Oncological Reconstructive Surgery
Decision making and patient care in oncological reconstructive surgery have considerably evolved in recent years. New surgical assistance technologies are helping surgeons push the boundaries of what…
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![Blood vessels imaged with THUNDER & Aivia Left-hand image: The distribution of immune cells (white) and blood vessels (pink) in white adipose tissue (image captured using the THUNDER Imager 3D Cell Culture). Right-hand image: The same image after automated analysis using Aivia, with each immune cell color-coded based on its distance to the nearest blood vessel. Image courtesy of Dr. Selina Keppler, Munich, Germany.](/fileadmin/_processed_/f/a/csm_Fat_tissue_THUNDER_THUNDER-Aivia_teaser_e142629a8c.jpg)
Accurately Analyze Fluorescent Widefield Images
The specificity of fluorescence microscopy allows researchers to accurately observe and analyze biological processes and structures quickly and easily, even when using thick or large samples. However,…
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![](/fileadmin/_processed_/d/7/csm_Considerations_for_multiplex_live_cell_imaging_teaser_a1d7945bbf.jpg)
Considerations for Multiplex Live Cell Imaging
Simultaneous multicolor imaging for successful experiments: Live-cell imaging experiments are key to understand dynamic processes. They allow us to visually record cells in their living state, without…
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![3D-volume-rendered light-sheet microscope image of a spheroid showing depth coding in different colors. 3D-volume-rendered light-sheet microscope image of a spheroid showing depth coding in different colors.](/fileadmin/_processed_/4/8/csm_Spheroid_showing_depth_coding_in_different_colors_3D_DLS_2cc9dea009.jpg)
Imaging of Anti-Cancer Drug Uptake in Spheroids using DLS
Spheroid 3D cell culture models mimic the physiology and functions of living tissues making them a useful tool to study tumor morphology and screen anti-cancer drugs. The drug AZD2014 is a recognized…
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![Electronic component Electronic component](/fileadmin/_processed_/a/1/csm_Electronic_component_1081697df6.jpg)
Top Challenges for Visual Inspection
This article discusses the challenges encountered when performing visual inspection and rework using a microscope. Using the right type of microscope and optical setup is paramount in order to…