Leica LMD6 and LMD7 Laser Microdissection Microscopes
Laser Microdissection (LMD, also known as Laser Capture Microdissection or LCM) enables users to isolate specific single cells or entire areas of tissue . Powered by a unique laser design and dynamic software , Leica LMD systems allow users to easily isolate Regions of Interest (ROI) from entire areas of tissue down to single cells or even subcellular structures such as chromosomes.
LMD is typically used in genomics (DNA), transcriptomics (mRNA, miRNA), proteomics, metabolomics, and even next generation sequencing (NGS). Researchers in neurology, cancer research, plant analysis, forensics or climate research rely on this method . Furthermore, LMD is a perfect tool for live cell culture (LCC), for cloning and re-cultivation, manipulation or downstream analysis.
Your Benefits:
- We move the laser, not the sample, for high precision cutting.
- Dissect & collect your samples in 96- and 384-well plates for high-throughput applications
- Easily collect differentials and controls in almost any size or shape
- Avoid sample contamination with our contact-free, gravity–based collection method
Gravity for Cleanliness
Your downstream analysis relies on contaminate-free isolates. This is why Leica LMD systems collect dissectates via gravity. Their unique laser-guidance based dissection method preserves the integrity of your isolates – contact-free and contamination-free.
1, 2, 3 – contamination-free sample!
- You choose the area of interest
- You move the laser along the area to be cut out
- The dissectate drops into the Petri dish and is ready for further analysis
The real asset: Gravity always works.
Interface for Artificial Intelligence
Aivia is our AI-based, image visualization, analysis and interpretation platform. with the help of AI-enhanced tools such as the Pixel Classifier, Aivia can be used to automatically define Regions of interest (ROI) which are destined for Laser Microdissection (LMD). ROIs can be detected by Aivia and imported directly into the LMD software for Microdissection.
Besides Aivia other external software can be used for automatic ROI detection. The LMD software simply needs an XML file containing the ROI information.
- Mund et al., Nature Biotechnology, 2022 https://doi.org/10.1038/s41587-022-01302-5
- Mitchell at al., JoVE, 2022 https://doi.org/10.3791/64171
