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Cancer Research

Senescence Reprogramming by TIMP1 Deficiency Promotes Prostate Cancer Metastasis
Ilaria Guccini, Ajinkya Revandkar, Mariantonietta D'Ambrosio, Manuel Colucci, Emiliano Pasquini, Simone Mosole, Martina Troiani, Daniela Brina, Raheleh Sheibani-Tezerji, Angela Rita Elia, Andrea Rinaldi, Nicolò Pernigoni, Jan Hendrik Rüschoff, Susanne Dettwiler, Angelo M. De Marzo, Emmanuel S. Antonarakis, Costanza Borrelli, Andreas E. Moor, Ramon Garcia-Escudero, Abdullah Alajati, Giuseppe Attanasio, Marco Losa, Holger Moch, Peter Wild, Gerda Egger, Andrea Alimonti,
Senescence Reprogramming by TIMP1 Deficiency Promotes Prostate Cancer Metastasis, Cancer Cell, 2020, ISSN 1535-6108

MYC as a driver of stochastic chromatin networks: implications for the fitness of cancer cells
Noriyuki Sumida, Emmanouil G Sifakis, Narsis A Kiani, Anna Lewandowska Ronnegren, Barbara A Scholz, Johanna Vestlund, David Gomez-Cabrero, Jesper Tegner, Anita Göndör, Rolf Ohlsson
Nucleic Acids Research, Volume 48, Issue 19, 4 November 2020, Pages 10867–10876, doi.org/10.1093/nar/gkaa817
Published: 13 October 2020

BMP6/TAZ-Hippo signaling modulates angiogenesis and endothelial cell response to VEGF
Pulkkinen, H.H., Kiema, M., Lappalainen, J.P. et al. BMP6/TAZ-Hippo signaling modulates angiogenesis and endothelial cell response to VEGF. Angiogenesis (2020). Published: October 2020

Pharmacological STING activation is a potential alternative to overcome drug-resistance in melanoma
Chipurupalli S, Ganesan R, Dhanabal SP, Kumar MS and Robinson N (2020) Pharmacological STING Activation Is a Potential Alternative to Overcome Drug-Resistance in Melanoma. Front. Oncol. 10:758. doi: 10.3389/fonc.2020.00758, May 2020

Cholesterol Homeostasis Modulates Platinum Sensitivity in Human Ovarian Cancer
Daniela Criscuolo, Rosario Avolio, Giovanni Calice, Chiara Laezza, Simona Paladino, Giovanna Navarra, Francesca Maddalena, Fabiana Crispo, Cristina Pagano, Maurizio Bifulco, Matteo Landriscina, Danilo Swann Matassa, and Franca Esposito
Cells 2020, 9(4), 828; March 2020

Novel renal medullary carcinoma cell lines, UOK353 and UOK360, provide preclinical tools to identify new therapeutic treatments
Wei D, Yang Y, Ricketts CJ, et al. Novel renal medullary carcinoma cell lines, UOK353 and UOK360, provide preclinical tools to identify new therapeutic treatments. Genes Chromosomes Cancer. 2020;59(8):472-483. doi:10.1002/gcc.22847

Immunology

DW14006 as a direct AMPKα1 activator improves pathology of AD model mice by regulating microglial phagocytosis and neuroinflammation
Jianlu Lv, Wei Wang, Xialin Zhu, Xiaoju Xu, Qiuying Yan, Jian Lu, Xiaofan Shi, Zhengyu Wang, Jinpei Zhou, Xi Huang, Jiaying Wang, Wenhu Duan, Xu Shen
Science Direct, Published: 30 July 2020

Enteric Nervous System-Derived IL-18 Orchestrates Mucosal Barrier Immunity
Abigail Jarret, Ruaidhrí Jackson, Coco Duizer, Yuval Kluger, Roni Novarski, et. al.
Research Journal: Cell; Volume 180, ISSUE 1, P50-63.e12, January 09, 2020

Essential function of the alveolin network in the subpellicular microtubules and conoid assembly in Toxoplasma gondii
Nicolò Tosetti, Nicolas Dos Santos Pacheco, Eloïse Bertiaux, Bohumil Maco, Lorène Bournonville, Virginie Hamel, Paul Guichard, Dominique Soldati-Favre; eLife 2020;9:e56635 doi: 10.7554/eLife.56635
https://elifesciences.org/articles/56635

Neurobiology

Divergent FUS phosphorylation in primate and mouse cells following double-strand DNA damage
Michelle A.Johnson, Qiudong Deng, Georgia Taylor, Zachary T. McEachin, Anthony W.S. Chan, Jessica Root, Gary J.Bassell, Thomas Kukar
Science Direct, Published: 2020 by Elsevier Inc.

Neuronal Lhx1 expression is regulated by DNMT1-dependent modulation of histone marks
Judit Symmank, Cathrin Bayer, Julia Reichard, Daniel Pensold & Geraldine Zimmer-Bensch (2020): Neuronal Lhx1 expression is regulated by DNMT1-dependent modulationof histone marks, Epigenetics, DOI: 10.1080/15592294.2020.1767372, May 2020

Characterization of a cell bridge variant connecting the nodose and superior cervical ganglia in the mouse: Prevalence, anatomical features, and practical implications
Angie L. Bookout, Laurent Gautron; First published: 01 May 2020; doi.org/10.1002/cne.24936
Funding information: National Institute of Diabetes and Digestive and Kidney Diseases, Grant/Award Number: 5 K01 DK116926‐02; NIH, Grant/Award Number: 1S10OD021684‐01; University of Texas Southwestern Medical Center, Grant/Award Number: Irwin & Irma Grossman Research Fund for Type I Dia

Developmental Biology

Transgenesis and web resources in quail
Olivier Serralbo, David Salgado, Nadège Véron, Caitlin Cooper, Marie-Julie Dejardin, Timothy Doran, Jérome Gros, Christophe Marcelle; Copyright: 2020, Serralbo et al.
eLife 2020;9:e56312 doi: 10.7554/eLife.56312

Left-right asymmetric heart jogging increases the robustness of dextral heart looping in zebrafish
Grimes D, Patterson V, Luna-Arvizu G, Schottenfeld-Roames J, Irons Z, et. al. 
Developmental Biology, 2019

Two-step mechanism for selective incorporation of lncRNA into a chromatin modifier
Marisa Müller, Tamas Schauer, Silke Krause, Raffaella Villa, Andreas W Thomae, Peter B Becker, Two-step mechanism for selective incorporation of lncRNA into a chromatin modifier, Nucleic Acids Research, gkaa492

Discrete regulation of β-catenin-mediated transcription governs identity of intestinal epithelial stem cells
Costanza Borrelli, Tomas Valenta, Kristina Handler, Karelia Vélez, Giulia Moro, Atefeh Lafzi, Laura de Vargas Roditi, George Hausmann, Andreas E Moor, Konrad Basler; bioRxiv 2020.05.19.103499; doi: doi.org/10.1101/2020.05.19.103499

A simple, quick, and efficient CRISPR/Cas9 genome editing method for human induced pluripotent stem cells
Geng, B., Choi, K., Wang, S. et al. A simple, quick, and efficient CRISPR/Cas9 genome editing method for human induced pluripotent stem cells. Acta Pharmacol Sin (2020). doi.org/10.1038/s41401-020-0452-0

Placental gene editing via trophectoderm-specific Tat-Cre/loxP recombination
Hatice O. Ozguldez, Rui Fan, Ivan Bedzhov
Development 2020 : dev.190371 doi: 10.1242/dev.190371 Published 15 June 2020, by The Company of Biologists Ltd

Physiology

Molecular imaging of fibroblast activity after myocardial infarction using a 68Ga-labelled fibroblast activation protein inhibitor FAPI-04
Varasteh Z, Mohanta S, Robu S, Braeuer M, Li Y, et. al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
2019 pp: jnumed.119.226993

Bmi1 inhibitor PTC-209 promotes Chemically-induced Direct Cardiac Reprogramming of cardiac fibroblasts into cardiomyocytes
Gianluca Testa, Michele Russo, Giorgia Di Benedetto, Matteo Barbato, Silvia Parisi, Flora Pirozzi, Carlo Gabriele Tocchetti, Pasquale Abete, Domenico Bonaduce, Tommaso Russo & Fabiana Passaro
Nature, Scientific Reports 10, Article numer: 7129 (2020)

Affinity Proteomics Identifies Novel Functional Modules Related to Adhesion GPCRs
Barbara Knapp, Jens Roedig, Karsten Boldt, Jacek Krzysko, Nicola Horn, Marius Ueffing, Uwe Wolfrum; First published: 22 August 2019; doi: 10.1111/nyas.14220

Biotechnology/Bioengineering

Optical coherence tomography-based tissue dynamics imaging for longitudinal and drug response evaluation of tumor spheroids
Ibrahim Abd El-Sadek, Arata Miyazawa, Larina Tzu-Wei Shen, Shuichi Makita, Shinichi Fukuda, Toshiharu Yamashita, Yuki Oka, Pradipta Mukherjee, Satoshi Matsusaka, Tetsuro Oshika, Hideaki Kano, and Yoshiaki Yasuno
Biomedical Optics Express Vol. 11, Issue 11, pp. 6231-6248 (2020)

Utility of direct 3D co-culture model for chondrogenic differentiation of mesenchymal stem cells on hyaluronan scaffold (Hyaff-11)
Iwona Deszcz, Anna Lis-Nawara, Piotr Grelewski, Szymon Dragan, Julia Bar
Regenerative Biomaterials, rbaa026, Published: 23 August 2020

Screening method to identify hydrogel formulations that facilitate myotube formation from encapsulated primary myoblasts
Dhananjay V. Deshmukh, Nils Pasquero, Gajraj Rathore, Joel Zvick, Ori Bar‐Nur, Jurg Dual, Mark W. Tibbitt
First published: 20 August 2020; doi.org/10.1002/btm2.10181

In Vivo Bioengineering of Fluorescent Conductive Protein-Dye Microfibers
Maria Moros, Francesca Di Maria, Principia Dardano, Giuseppina Tommasini, Hiram Castillo-Michel, Alessandro Kovtun, Mattia Zangoli, Martina Blasio, Luca De Stefano, Angela Tino, Giovanna Barbarella, Claudia Tortiglione; Published April 24, 2020, by ScienctDirect. doi.org/10.1016/j.isci.2020.101022

Performance of mycelial biomass and exopolysaccharide from Malaysian Ganoderma lucidum for the fungivore red hybrid Tilapia (Oreochromis sp.) in Zebrafish embryo
Norhidayah Mohd Taufek, Hanis H.Harith, Muhamad HafizAbd Rahim, Zul lham, Neil Rowan, Wan Abd Al Qadr Imad Wan-Mohtar, Aquaculture Reports, ISSN: 2352-5134, Vol: 17, Page: 100322, 2020

Culture and Differentiation of Human Hair Follicle Dermal Papilla Cells in a Soft 3D Self-Assembling Peptide Scaffold
Betriu, N.; Jarrosson-Moral, C.; Semino, C.E.
Biomolecules 2020, 10, 684.

Transgenesis and web resources in quail
Olivier Serralbo, David Salgado, Nadège Véron, Caitlin Cooper, Marie-Julie Dejardin, Timothy Doran, Jérome Gros, Christophe Marcelle; eLife 2020;9:e56312 doi: 10.7554/eLife.56312

A simple, quick, and efficient CRISPR/Cas9 genome editing method for human induced pluripotent stem cells
Geng, B., Choi, K., Wang, S. et al. A simple, quick, and efficient CRISPR/Cas9 genome editing method for human induced pluripotent stem cells. Acta Pharmacol Sin (2020). doi.org/10.1038/s41401-020-0452-0

Biochemistry

Dual Role of a Rubisco Activase in Metabolic Repair and Carboxysome Organization
Mirkko Flecken, Huping Wang, Leonhard Popilka, Ulrich Hartl, Andreas Bracher, Manajit Hayer-Hartl; bioRxiv 2020.05.16.099382; doi: https://doi.org/10.1101/2020.05.16.099382

Pharmacology

Comparative Anti-inflammatory Effect of Curcumin at Air-Liquid Interface and Submerged Conditions using Lipopolysaccharide Stimulated Human Lung Epithelial A549 Cells
Yue Hu, Yunhua Sheng, Xiaoli Ji, Ping Liu, Liming Tang, Gang Chen, Guiliang, Chenbd; published on ScienceDirect, August 2020, doi.org/10.1016/j.pupt.2020.101939

A Novel, Pan-PDE Inhibitor Exerts Anti-Fibrotic Effects in Human Lung Fibroblasts via Inhibition of TGF-β Signaling and Activation of cAMP/PKA Signaling
Wójcik-Pszczoła, K.; Chłoń-Rzepa, G.; Jankowska, A.; Ślusarczyk, M.; Ferdek, P.E.; Kusiak, A.A.; Świerczek, A.; Pociecha, K.; Koczurkiewicz-Adamczyk, P.; Wyska, E.; Pękala, E.; Gosens, R. A Novel, Pan-PDE Inhibitor Exerts Anti-Fibrotic Effects in Human Lung Fibroblasts via Inhibition of TGF-β Signaling and Activation of cAMP/PKA Signaling. Int. J. Mol. Sci. 2020, 21, 4008.