Leica LMD6 & LMD7 레이저 미세절단 현미경 시스템
완벽한 해부
This curated list features recent scientific publications that have employed Leica’s LMD6 and LMD7 laser microdissection systems in key areas such as cancer research, neuroscience, molecular pathology, forensics, and spatial omics. It is updated regularly to reflect the latest scientific publications utilizing laser microdissection applications.
Explore the full list below to see how Leica LMD systems are enabling scientific success across the globe.
Download the complete list of LMD publications in "Downloads"
Single Cell Applications
Maternal Choline Supplementation in a Mouse Model of Down Syndrome and Alzheimer's Disease Generates Unique Expression Profile Mosaics Within Three Hippocampal Excitatory Neuronal Populations
Alldred MJ, Ibrahim KW, Pidikiti H, Lee SH, Heguy A, Chiosis G, Mufson EJ, Stutzmann GE, Ginsberg SD
FASEB J. 2026 Apr 15;40(7):e71625. doi: 10.1096/fj.202504243R.
Pathogenic Role of SERPINB3-positive Neutrophils in Reinforcing Thrombus Stiffening during Ischemic Stroke
Zang J, Lu A, Yang B, Tan N, Liu Q, Wei L, Liang Y, Zhou S, Tan Z, Xin X, He S, Wu P, Li Y, Xu Z, Su X, Mai H, Xu A, Lu D
Blood. 2026 Mar 3:blood.2025029516. doi: 10.1182/blood.2025029516.
Single-cell spatial proteomics maps human liver zonation patterns and their vulnerability to disruption in tissue architecture
Weiss CAM, Brown LA, Miranda L, Pellizzoni P, Steigerwald S, Remmert K, Hernandez JM, Borgwardt K, Kleiner DE, Ben-Moshe S, Rosenberger FA, Porat-Shliom N, Mann M
Nat Metab. 2026 Feb 20. doi: 10.1038/s42255-026-01459-2.
Spatial Genomics (DNA-Reserach)
New insights into the feeding behaviour of the Japanese squid Todarodes pacificus paralarvae, and a combined analysis of metagenome and amino acid isotope ratios
Adachi K, Chikaraishi Y, Nomura S, Goto-Inoue N, Zaima N, Kuriya Y, Araki M, Morioka K, Yanagimoto T, Nakaya M, Yamamoto J
PLoS One. 2026 Mar 16;21(3):e0340579. doi: 10.1371/journal.pone.0340579.
First molecular documentation of a bucephalid trematode in Ostrea denselamellosa (South Korea): Phylogenetic placement, histopathology, and seasonal prevalence
Chen Y, Udayantha HMV, Long J, Kim S-H, Kalhari WAAH, Bathige SDNK, Park K-I
Aquaculture, 5 March 2026, 743851
Subclonal Complete Loss of CDKN1B as a Common Genomic Alteration in Prostate Cancer: Associations with Race and Prostate Cancer Outcomes
Sfanos KS, Morton R, Flores JN, Sosa RY, Ernst SE, Mummert L, Hicks J, Lotan TL, Lu J, Jing Y, Joshu CE, De Marzo AM
bioRxiv, March 5, 2026
Spatial Transcriptomics (RNA Research)
Anti-PECAM-1 antibodies: another tool for visualization of Reissner´s fiber and the subcommissural organ in rat central nervous system.
Malčický L, Košuth J, Barčák D, Zrubáková J, Vancová M, Daxnerová Z, Ševc J, Alexovič Matiašová A
Brain Struct Funct. 2026 Apr 4;231(3):50. doi: 10.1007/s00429-026-03088-7.
Spongy mesophyll cell death is induced by jasmonic acid during leaf senescence in chrysanthemum
Song J, Zhang Y, Hu X, Shao Z, Song A, Jiang J, Chen S, Chen F, Wang L
Plant Cell. 2026 Mar 26:koag095. doi: 10.1093/plcell/koag095.
PtrSHR1 coordinates vascular cambium proliferation and xylem lignin biosynthesis to regulate wood formation in Populus trichocarpa
Zhao J, Chen Y, Dai X, Su L, Zhai R, Sun Y, Ji P, Wang H, Li S, Zhou C, Tobimatsu Y, Umezawa T, Chiang VL, Li W
Plant Cell. 2026 Mar 23:koag091. doi: 10.1093/plcell/koag091.
Proteomics, Lipidomics, Metabolomics
Preparation Of Neovascular Tissues from Human Glioma Tissues for Quantitative Proteomics Analysis of Tumor Angiogenesis
Feng X, Fang Z, Zhan X, Guo T, Zhang Y, Yin Z, Zhang Y, Li N, Zhan X
Journal of Visualized Experiments , 2026 (229), DOI: 10.3791/69547
Pan-cancer multi-omic ERBB2-HER2 characterization using next-generation sequencing and quantitative proteomics
Hunt AL, Randall J, Ogata JD, Johnston L, Swain W, Melvin S, Sharma M, Calvert V, Maxwell GL, Bateman NW, Petricoin EF, Conrads TP, Cannon TL
NPJ Precis Oncol. 2026 Mar 5. doi: 10.1038/s41698-026-01351-y.
Pathogenic Role of SERPINB3-positive Neutrophils in Reinforcing Thrombus Stiffening during Ischemic Stroke
Zang J, Lu A, Yang B, Tan N, Liu Q, Wei L, Liang Y, Zhou S, Tan Z, Xin X, He S, Wu P, Li Y, Xu Z, Su X, Mai H, Xu A, Lu D
Blood. 2026 Mar 3:blood.2025029516. doi: 10.1182/blood.2025029516.
Deep Visual Proteomics (DVP) related
Single-cell spatial proteomics maps human liver zonation patterns and their vulnerability to disruption in tissue architecture
Weiss CAM, Brown LA, Miranda L, Pellizzoni P, Steigerwald S, Remmert K, Hernandez JM, Borgwardt K, Kleiner DE, Ben-Moshe S, Rosenberger FA, Porat-Shliom N, Mann M
Nat Metab. 2026 Feb 20. doi: 10.1038/s42255-026-01459-2.
Spatial protein gradients pattern liver metabolism
Dong Z, Guo T
Nat Metab (2026). doi.org/10.1038/s42255-026-01478-z
Laser Capture Microdissection: Methods and Protocols: Immunofluorescence Imaging-Guided Laser Microdissection for Ultralow Input Spatial Tissue Proteomics
Fritzsche S, Coscia F in Roberta Noberini (ed.)
Methods in Molecular Biology, vol. 3015
Fluorescence Applications
Pathogenic Role of SERPINB3-positive Neutrophils in Reinforcing Thrombus Stiffening during Ischemic Stroke
Zang J, Lu A, Yang B, Tan N, Liu Q, Wei L, Liang Y, Zhou S, Tan Z, Xin X, He S, Wu P, Li Y, Xu Z, Su X, Mai H, Xu A, Lu D
Blood. 2026 Mar 3:blood.2025029516. doi: 10.1182/blood.2025029516.
Laser Capture Microdissection: Methods and Protocols: A Spatial Proteomics Approach to Isolate and Analyze Amyloid Proteins Using Laser Capture Microdissection and Mass Spectrometry
Aguilan J, Horton M, Pessin JE, and Sidoli S in Roberta Noberini (ed.)
Methods in Molecular Biology, vol. 3015
Separation and identification of two-individual mixed bloodstains using human neutrophil antigen-1 antibodies
Xia X, Zheng JL, Wang SW, Liu Z, Li Z, Wang DY, Li XN, Wu X, Yao J
Int J Legal Med. 2026 Jan 27. doi: 10.1007/s00414-026-03718-z.
Cancer Research
Preparation Of Neovascular Tissues from Human Glioma Tissues for Quantitative Proteomics Analysis of Tumor Angiogenesis
Feng X, Fang Z, Zhan X, Guo T, Zhang Y, Yin Z, Zhang Y, Li N, Zhan X
Journal of Visualized Experiments , 2026 (229), DOI: 10.3791/69547
Pan-cancer multi-omic ERBB2-HER2 characterization using next-generation sequencing and quantitative proteomics
Hunt AL, Randall J, Ogata JD, Johnston L, Swain W, Melvin S, Sharma M, Calvert V, Maxwell GL, Bateman NW, Petricoin EF, Conrads TP, Cannon TL
NPJ Precis Oncol. 2026 Mar 5. doi: 10.1038/s41698-026-01351-y.
A disease model resource reveals core principles of tissue-specific cancer evolution
Mueller S, de Andrade Krätzig N, Tschurtschenthaler M, Silva MG, Thordsen C, Trozzo R, Simon P, Saab F, Kaltenbacher T, Zukowska M, Lucarelli D, Öllinger R, Griger J, Groß N, Groll T, Löprich J, Zaurito AE, Schömig LR, Bugter JM, Bärthel S, Falcomatà C, Strong A, Brandt C, Najajreh M, Papargyriou A, Maresch R, Collins KAN, Sailer D, Schneeweis C, Burger S, Fröhlich LM, Klement C, Belka A, Montero JJ, Jungwirth U, Reichert M, Moser M, Neumann J, Vassiliou G, Cadiñanos J, Varela I, Marr C, Alonso DF, Lollini PL, Zhao J, Chesler L, Isacke CM, Riedel A, Braun CJ, Sos ML, Beleggia F, Reinhardt HC, Musteanu M, Barbacid M, Quante M, Schmidt-Supprian M, Schneider G, Clare S, Lawley TD, Dougan G, Steiger K, Conte N, Bradley A, Rad L, Saur D, Rad R
Nature. 2026 Feb 25. doi: 10.1038/s41586-026-10187-2.2
Neurosciences
Maternal Choline Supplementation in a Mouse Model of Down Syndrome and Alzheimer's Disease Generates Unique Expression Profile Mosaics Within Three Hippocampal Excitatory Neuronal Populations
Alldred MJ, Ibrahim KW, Pidikiti H, Lee SH, Heguy A, Chiosis G, Mufson EJ, Stutzmann GE, Ginsberg SD
FASEB J. 2026 Apr 15;40(7):e71625. doi: 10.1096/fj.202504243R.
Anti-PECAM-1 antibodies: another tool for visualization of Reissner´s fiber and the subcommissural organ in rat central nervous system.
Malčický L, Košuth J, Barčák D, Zrubáková J, Vancová M, Daxnerová Z, Ševc J, Alexovič Matiašová A
Brain Struct Funct. 2026 Apr 4;231(3):50. doi: 10.1007/s00429-026-03088-7.
NeMO Analytics: a compendium of transcriptomic data for the exploration of neocortical development
Sonthalia S, Herb B, Adkins RS, Orvis J, Li G, Liao X, Yu Q, Blanco XM, Casella A, Liu J, Stein-O'Brien G, Caffo B, Hertzano R, Mahurkar A, Xu JC, Gillis J, Werner J, Ma S, Kim SK, Micali N, Sestan N, Rakic P, Santpere G, Ament SA, Colantuoni C
Nat Neurosci. 2026 Mar 25. doi: 10.1038/s41593-026-02204-4.
Clinical/Pathology/Immunology Research Applications
Giant Cell Arteritis With Medin-Derived Amyloid (AMed) Deposition in a Patient With COVID-19: An Autopsy Case
Ichimata S, Yoshinaga T, Sato M, Katoh N, Kametani F, Morinaga Y, Yazaki M, Sekijim Y
Pathol Int. 2026 Mar;76(3):e70100. doi: 10.1111/pin.70100.
Possible involvement of tubular interleukin-34 in macrophage recruitment during colistin-induced nephrotoxicity in rats
Matsushita K, Akane H, Akagi JI, Morikawa T, Mizuta Y, Ogawa K, Toyoda T
J Toxicol Sci. 2026;51(3):163-172. doi: 10.2131/jts.51.163.
Single-cell spatial proteomics maps human liver zonation patterns and their vulnerability to disruption in tissue architecture
Weiss CAM, Brown LA, Miranda L, Pellizzoni P, Steigerwald S, Remmert K, Hernandez JM, Borgwardt K, Kleiner DE, Ben-Moshe S, Rosenberger FA, Porat-Shliom N, Mann M
Nat Metab. 2026 Feb 20. doi: 10.1038/s42255-026-01459-2.
Developmental Research, Epigenetics & Aging
Fetal inflammatory signals regulate maternal investment during marsupial pregnancy
Stadtmauer DJ, Maziarz JD, Griffith OW, Wagner GP
PLoS Biol. 2026 Feb 24;24(2):e3003670. doi: 10.1371/journal.pbio.3003670.
A high-quality RNA-yielding protocol for laser capture microdissection of transplanted stem cell-derived Islets of Langerhans
Norman D, Lau J
Acta Diabetol. 2026 Feb 9. doi: 10.1007/s00592-026-02654-z.
Comparative insights into molecular pathways influencing germline development in early-divergent angiosperms
Lora J, Tucker MR, Shirley NJ, Ma C, Hormaza JI
Plant J. 2026 Jan;125(2):e70675. doi: 10.1111/tpj.70675.
Plant Research
Spongy mesophyll cell death is induced by jasmonic acid during leaf senescence in chrysanthemum
Song J, Zhang Y, Hu X, Shao Z, Song A, Jiang J, Chen S, Chen F, Wang L
Plant Cell. 2026 Mar 26:koag095. doi: 10.1093/plcell/koag095.
PtrSHR1 coordinates vascular cambium proliferation and xylem lignin biosynthesis to regulate wood formation in Populus trichocarpa
Zhao J, Chen Y, Dai X, Su L, Zhai R, Sun Y, Ji P, Wang H, Li S, Zhou C, Tobimatsu Y, Umezawa T, Chiang VL, Li W
Plant Cell. 2026 Mar 23:koag091. doi: 10.1093/plcell/koag091.
Comparative insights into molecular pathways influencing germline development in early-divergent angiosperms
Lora J, Tucker MR, Shirley NJ, Ma C, Hormaza JI
Plant J. 2026 Jan;125(2):e70675. doi: 10.1111/tpj.70675.
Forensics
Separation and identification of two-individual mixed bloodstains using human neutrophil antigen-1 antibodies
Xia X, Zheng JL, Wang SW, Liu Z, Li Z, Wang DY, Li XN, Wu X, Yao J
Int J Legal Med. 2026 Jan 27. doi: 10.1007/s00414-026-03718-z.
Invisible WItness: Innovations in the Collection of Touch DNA and the Risk of Forensic Corss Contamination
Irfan M, Haider SA, Yasir M, Akram MA, Adeel M
FORENSIC INSIGHTS AND HEALTH SCIENCES BULLETIN, Volume 3: Issue 2: 2025
Advancements in differentiation between sperm cells and epithelial cells for efficient forensic DNA analysis in sexual assault cases
Dash HR
Int J Legal Med. 2024 Jul 12. doi: 10.1007/s00414-024-03285-1.
Miscellaneous
New insights into the feeding behaviour of the Japanese squid Todarodes pacificus paralarvae, and a combined analysis of metagenome and amino acid isotope ratios
Adachi K, Chikaraishi Y, Nomura S, Goto-Inoue N, Zaima N, Kuriya Y, Araki M, Morioka K, Yanagimoto T, Nakaya M, Yamamoto J
PLoS One. 2026 Mar 16;21(3):e0340579. doi: 10.1371/journal.pone.0340579.
Ischemic injury to primary motor and premotor cortices is linked to hyperreflexia in mice
Kaul S, Liu L, Candelario-Jalil E, Vahdat S
Neurobiol Dis. 2026 Mar 14:107354. doi: 10.1016/j.nbd.2026.107354.
First molecular documentation of a bucephalid trematode in Ostrea denselamellosa (South Korea): Phylogenetic placement, histopathology, and seasonal prevalence
Chen Y, Udayantha HMV, Long J, Kim S-H, Kalhari WAAH, Bathige SDNK, Park K-I
Aquaculture, 5 March 2026, 743851
Live Cell Culture
Muscle Structure and Function Recovery: Adalimumab-Calcium Channel Synergy in Post-Ischemic Stroke Sarcopenia
Qi H, Zhang XW, Zhang ZY, Ou SS, Gao YL, Tian D, Jiang YN, Min XR, Zhao AT, Zou JM, Zeng JS, Pu QY, Yang RC, Zeng N
J Cachexia Sarcopenia Muscle. 2025 Dec;16(6):e70097. doi: 10.1002/jcsm.70097.
Ultrasensitive proteomics uncovers nociceptor diversity and novel pain targets
Chakrabarti S, Makhmut A, Mohammadi A, Luo W, Wang L, Lewin GR, Coscia F
bioRxiv, Sept 21, 2025
A 3‑Dimensional Scaffolding System Recapitulates the Hierarchical Osteon Structure
Li X, Sun Y, Wang S, Si C, Li H, and Chang B
ACS Omega 2024, XXXX, XXX, XXX-XXX
Laser microdissection (LMD) is an advanced, highly precise sample preparation technique that enables researchers to isolate pure, defined regions of interest, including single cells, from complex tissue samples. The method ensures reproducibility and accuracy for downstream analyses such as Next Generation Sequencing (NGS) including RNA-seq, and mass spectrometry for spatial genomics, spatial transcriptomics, spatial proteomics & spatial multiomics.
LMD allows non-contact dissection, isolation and gravity-assisted collection of targeted single cells, tissue compartments, cell clusters and even subcellular structures under visual control. These systems uniquely bridge microscopy and molecular biology to unlock true spatial omics insights. Combined with software-guided segmentation, Leica LMD systems enable high throughput workflows for biomarker discovery and identification of therapeutical interaction points. The study by Mund & Coscia et al., describing the Deep Visual Proteomics (DVP) workflow powered by the Leica LMD7 system, was featured on the cover of Nature Biotechnology in August 2022. Follow-up research by Nordmann et al., published in Nature in 2024, demonstrated how DVP contributed to a life-saving therapy for toxic epidermal necrolysis (TEN), a deadly skin disease. These breakthroughs also contributed to the selection of “spatial proteomics” as Nature’s Method of the Year 2024.
