Your Road to Super-Sensitivity Leica HyD

The GaAsP hybrid detection system Leica HyD for confocal imaging with Leica TCS SP5 II significantly improves image quality and detection efficiency. Its deep contrast delivers publication-ready images.

Leica HyD offers fully multi-spectral imaging with up to 4 super-sensitive detectors. The Leica HyD SP detector records photon streams with hundreds of photon counts per second. It addresses very bright and dynamic samples and offers as well single photon sensitivity by a photon counting mode in LAS AF.

Its high quantum efficiency, low dark noise, and large dynamic range make the Leica HyD the most versatile confocal detector.

Your Advantages


Low dark noise improves z-stacks of neuromuscular junctions Critical live samples need to be imaged under low light conditions in high gain situations. Low noise can become the decisive advantage when it comes to recognizing weakly stained detail.	Increased cell viability permits yeast imaging with a confocal point scanner High sensitivity directly translates into reduction in light dosage delivered to the sample. Even delicate systems, such as yeast, are accessible to HyD detection – at full confocal resolution. Conversely, Leica HyD's two-time higher quantum efficiency permits to double acquisition speed.
High sensitivity for single molecules Fixed single molecules represent the ultimate frontier to imaging. When measuring such weak signals close to a reflective surface, sensitivity, dark noise and the efficiency of the beam splitting system are stretched to their limits. Note the blinking (half moon-shapes and horizontal lines) testifying the single molecule nature of the diffraction limited spots.	High speed makes C. elegans embryogenesis accessible In order to unravel the spatio-temporal formation of structure one needs to find the right balance between acquisition speed and clarity. Along with Leica‘s pioneering Tandem Scanner the HyD offers an unprecedented image quality. The tandem scanner‘s 8000 Hz line frequency comfortably leave room for averaging or accumulation as needed, while maintaining a large field of view.


Open upgrade path Along with biology‘s dynamic nature go rapidly changing needs in your lab. In acknowledgement of that the HyD concept was designed with upgradeability in mind. You can equip up to four HyD modules right away for parallel detection of up to four multi-spectral super-sensitive channels. Different configurations of the spectral scan head allow for a customized balance between super-sensitivity and dynamic range.

Direct contact, consulting and support

Find your local Leica Microsystems partner
Get quotes - profit from owning a Leica Microsystems product
Tailored advice - learn about the benefits Leica Microsystems provides for your work situation

Ask for more