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EM Sample Preparation Biological Specimens

To achieve the best results during the examination of your sample in the Electron Microscope, the perfect EM Sample Preparation (TEM sample preparation, SEM Sample Preparation) is a prerequisite.

With its comprehensive product portfolio for the preparation of biological, clinical and medical samples, Leica Microsystems offers you system solutions for all your workflows during EM Sample Preparation.

These techniques can be performed with Leica Microsystems’ highly sophisticated, high-precision and easy to use instruments at room or low temperature:

  • EM Embedding
  • EM Tissue Processing
  • EM Coating
  • Immunogold Labeling
  • Ultrathin Sectioning with Ultramicrotomes
  • Cryo-Ultramicrotomy
  • Cryosectioning
  • Critical Point Drying
  • Plunge Freezing
  • Freeze Substitution
  • Freeze Fracturing
  • Freeze Drying
  • EM Contrasting
  • Cryofixation
  • High Pressure Freezing
  • Cryo Transfer

System Solutions for EM Sample Preparation of Biological Specimens:

Leica EM Cryo CLEM Leica EM CTD Leica EM ACE600 Leica EM ACE200
Leica EM Cryo CLEM Correlating Cryofixed Biological Samples in the Light- and Electron Microscope

The innovative Leica EM Cryo CLEM set for widefield lightmicroscopy with the 

Leica EM CTD Fast, Reliable Cryo Tool Drying for Efficient Cryo EM workflow

During Cryo preparation, tools such as forceps and sample holders often ice over and cannot be immediately used for the next sample run. De-icing and...

Leica EM ACE600 High Vacuum Coater

Your choice for highest resolution for TEM and FE-SEM analysis. The Leica EM ACE600 is the perfect versatile high vacuum film deposition...

Leica EM ACE200 Low Vacuum Coater

Producing homogenous and conductive metal or carbon coatings for SEM and TEM analysis was never before more convenient than with the Leica EM ACE200...

Leica EM SPF
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Leica EM CPD300 Leica EM GP Leica EM UC7
Leica EM SPF Self Pressurised Freezer

Are you looking for an alternative cryo-fixation method to freeze your biological specimens such as cells, free-living bacteria, yeast cells,...

Leica EM CPD300 Automated Critical Point Dryer

The drying of biological specimens such as pollen, tissue, plants, insects, as well as industrial samples, for example MEMS (Micro Electro Mechanical...

Leica EM GP Automatic Plunge Freezing with Bare Grid Technique

For the preparation of vitrified fluid samples or extremely thin samples for cryo-TEM, including biological suspensions and industrial emulsions...

Leica EM UC7 Ultramicrotome for Perfect Sectioning at Room Temperature and Cryo


Leica EM KMR3 Leica EM FC7 Leica EM AMW Leica EM AFS2
Leica EM KMR3 Glass Knifemaker

Perfect Glass Knives for perfect ultrathin sections for EM and LM applications The balanced break method of the Leica EM KMR3 ensures perfect...

Leica EM FC7 Cryochamber for Leica EM UC7 and EM UC6

Change your Ultramicrotome Leica EM UC6 or Leica EM UC7 to a Cryoultramicrotome within minutes by mounting the Cryochamber Leica EM FC7 and...

Leica EM AMW Automatic Microwave Tissue Processor for Electron Microscopy

With minimal user interface, rapidly process, embed, and polymerize specimens into resin with the Leica EM AMW’s...

Leica EM AFS2 Freeze Substitution and Low Temperature Embedding System for Light and Electron Microscopy

The Leica EM AFS2 performs freeze substitution and progressive lowering of temperature (PLT) techniques and allows low...

Leica EM RAPID Leica EM TRIM2 Leica EM TP Leica EM AC20
Leica EM RAPID Pharmaceutical Milling System for Pills

The Leica EM RAPID milling system for pharmaceutical research enables sample preparation for analysis of active ingredient...

Leica EM TRIM2 Specimen trimming device for TEM, SEM, LM

The Leica EM TRIM2 is a high speed milling system with integrated stereomicroscope and LED ring illuminator for trimming of biological and...

Leica EM TP Automated routine tissue processor

The innovative Leica EM TP is the first tissue processor designed for EM and LM resin processing, that features a heating/cooling...

Leica EM AC20 Automatic contrasting instrument for ultrathin sections

The Leica EM AC20 automatic contrasting system for ultrathin sections ensures minimum user contact with reagents and reduced...

Leica EM BAF060 Leica EM VCT100 Leica EM HPM100 Leica EM PACT2
Leica EM BAF060 Freeze Fracture System

The Leica EM BAF060 is a high-end sample preparation system for freeze fracturing, etching, and freeze drying of double...

Leica EM VCT100 Vacuum cryo transfer system

The Leica EM VCT100 is a contamination-free cryo transfer system which cross-links preparation units with various analysis...

Leica EM HPM100 High Pressure Freezer for Cryofixation of Biological And Industrial Samples

The Leica EM HPM100 is a high pressure freezing system for vitrifying samples up to 200µm in thickness. The unique 6 mm diameter carrier...

Leica EM PACT2 High Pressure Freezer With Rapid Transfer System

The Leica EM PACT2 is a high pressure freezing system for vitrifying samples up to 200µm in thickness without the artefacts of chemical...