Neuroscience
The nervous system is a tightly regulated, highly complex network. Besides gaining knowledge of the single neuronal cell, the understanding of the network as a whole is of major importance to understand how billions of neurons perform their task in the brain, how changes on molecular level are connected with pathogenesis and how neuronal networks are capable of learning and memory. With the help of microscopic techniques scientists are encountering many exciting questions, whose answers they are putting together like pieces of a puzzle.
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Abstract
05. Mar 2012 Institutes: Max Planck Institute for Experimental Medicine, Göttingen, Germany, Max Planck Institute for Biophysical Chemistry, Department of NanoBiophotonics, Göttingen, GermanyTo explore the most intricate structures of the brain in order to decipher how it functions – Stefan Hell’s team of researchers at the Max Planck Institute for Biophysical Chemistry in Göttingen has made a significant step closer to this goal. Using the STED microscopy developed by Hell, the… Read article
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Article
22. Feb 2012 Institutes: National Research Council (CNR), Neuroscience Institute, Pisa, Italy, University of Trento, Centre for Integrative Biology (CIBIO), High Throughput-High Content Screening and Microarray Facilities, Italy, Royal College of Surgeons (RCSI), Department of Physiology, Dublin, Ireland, University of Trento, Centre for Integrative Biology (CIBIO), Laboratory of Molecular Neuropathology, Italy, University of Trento, Centre for Integrative Biology (CIBIO), Laboratory of Developmental Neurobiology, ItalyDifferent areas of the Central Nervous System (CNS) display a specific and selective gene expression profile. Here, we used the Laser Microdissection system Leica LMD6500 to study region-specific mRNA expression in the adult mouse retina and hippocampus. Read article
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Article
10. Feb 2012 Institute: Leica Microsystems, Wetzlar, GermanyOptogenetics is a technique that allows light-controlled responses of transfected cells. The cells are genetically modified by introduction of genes that code for light-induced channels or ion pumps. The term optogenetics denotes the light control feature introduced by genetic engineering. Read article
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Article
07. Feb 2012 Institutes: University of California, Molecular and Cell Biology, Berkeley, CA, USA, Harvard Medical School, Department of Cell Biology, Boston, MA, USA, American Society for Cell Biology, Bethesda, MD, USAThe need for data validation and accessibility has never been greater than it is today. We are inundated with information from a multitude of resources, but how can we easily evaluate the accuracy of that data? In the past, the peer review process provided this and was often run by publishers. Read article
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Tutorial
12. Dec 2011 Institute: Leica Microsystems, Wetzlar, GermanyMany fundamental functions of a cell strongly depend on delicate, but nevertheless dynamic balances of ions (e.g. calcium, magnesium), voltage potentials and pH between the cell’s cytosol and the surrounding extracellular space. Ratiometric imaging allows reliable estimations of ion concentrations… Read article
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Tutorial
12. Dec 2011 Institute: Leica Microsystems, Wetzlar, GermanyRatiometric imaging is widely used to study highly dynamic intracellular ion, voltage or pH changes. The most common application, however, is calcium imaging. Ratiometric imaging is also used for investigating cellular networks, where e.g. relative calcium concentrations are passed among cells or… Read article
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Tutorial
02. Dec 2011 Institute: Allen Instutite for Brain Science, Seattle, WA, USAHow can we begin to understand the complexity of the human brain and the way it works? The same way we begin to understand a city: by making a map. In this talk, Allan Jones shows how his team is mapping which genes are turned on in each tiny region, and how it all connects up. Read article
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Tutorial
09. Nov 2011 Institute: Philipps University Marburg, Institute of Cytobiology and Cytopathology, GermanyEspecially in neuroscience, the physiology of ion channels has always been a major topic of interest. The development of the patch-clamp technique in the late 1970s has given electrophysiologists new prospects. It allows high-resolution current recordings not only of whole cells, but also of excised… Read article
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Article
09. Nov 2011 Institute: Leica Microsystems, Wetzlar, GermanyNeurobiology, the science of nerves and the brain, has mainly been driven forward in the last 200 years by microscopic investigations. The structures of cellular and subcellular structures, interaction and the three-dimensional assembly of neurons were made visible by various microscopy techniques.… Read article
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Article
09. Jun 2011 Institute: Leica Microsystems, Wetzlar, GermanyPublications using STED microscopy Read article
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Article
13. Apr 2011 Institutes: Leica Microsystems, Wetzlar, Germany, University of California, Department of Anatomy & Neurobiology, Irvine, USAA combination of widefield imaging techniques and image segmentation analysis enable researchers to map learning-induced functional changes in individual synapses throughout the hippocampus. Read article
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Article
02. Nov 2010 Institutes: LabScience Communications, Grafing, Germany, University of Ulm, Institute of Applied Physiology, GermanyA characteristic sign of M. Parkinson is the deterioration of dopaminergic neurons in the mid-brain, specifically in the substantia nigra (SN, black substance). Different causes and forms of this disease have been identified. In the case of the genetic familial form, for example, it has been… Read article
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