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Super-Resolution Microscopes

Super-resolution microscopy overcomes the diffraction limit of light and allows investigators to study subcellular structures in greater detail than is possible with a confocal microscope. Resolutions down to 20 nm are possible; in biology this represents the length of 10 average proteins end to end or 60 base pairs of DNA. With the introduction of the very first super-resolution microscope in 2004, and now our Leica TCS SP8 STED 3X and Leica SR GSD 3D, Leica Microsystems revolutionized opportunities for life science research allowing novel discoveries to be made in the fields of virology, neuroscience and cancer.

True to the credo of Ernst Leitz ‘with the user, for the user’, Leica Microsystems has pioneered super-resolution by collaborating closely with leading scientists such as the Nobel Prize laureate Stefan Hell, as well as industry partners. This approach continuously improves the performance of our super-resolution microscopy systems. With 10 years of experience in the field, today we offer more than excellent products: Our commitment to high standards of service and support is also a key priority for Leica Microsystems.

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Contact a local imaging specialist for expert advice on the right Super-Resolution system for your needs.

Super-Resolution Applications Beyond Limits

Leica SR GSD Application

Comparison of a 3D reconstruction of GSD and wide-field images. Mitochondrial ATP-Synthase in MDCK cells stained with anti-ATP-2B/Alexa647. The color code indicates the total height of the image. Courtesy of R. Jacob, Marburg, Germany (sample preparation).

Leica TCS SP8 STED 3X Application

Comparison of Confocal (red) and 3D STED data sets (green). Alpha Tubulin visualized with Oregon Green 488. Marine Dinoflagelatte Amphidinium spec. Data were deconvolved and surface rendered with Huygens (SVI). Courtesy of Elisa Berdalet, CSIC Institute of Marine Sciences/Timo Zimmermann, Center for Genomic Regulation, Barcelona, Spain.

Leica SR GSD 3D - The Evolution of Resolution

The Leica SR GSD 3D widefield super-resolution imaging system offers unparalleled abilities to study biological processes in multi dimensions beyond the diffraction barrier down to the molecular level.

  • Up to 10 times higher resolution in 3 dimensions
  • Simple multi-channel imaging capability
  • SuMo Stage delivers unprecedented stability
  • 160x objective optimized for use with high intensity lasers
  • Compatible with many standard fluorophores

Leica TCS SP8 STED 3X - Your Next Dimension

The Leica TCS SP8 STED 3X opens the door to fast, direct, and purely optical super-resolution over the full spectrum of visible light, in all dimensions.

Super Resolution Latest News

GSD Around the World – A Travel Diary on Facebook


Tamara Straube and Peter Laskey will take you on a journey around the world: Together with a team of specialists, they visited 10 countries, organized 11 workshops for GSD super-resolution microscopy, imaging and sample preparation, and met more than...

EMBL Advanced Course – Intensive Super-Resolution Microscopy Course for Localization Microscopy and STED


From 20th to 25th July 2015 the EMBL (European Molecular Biology Laboratory), Heidelberg will be holding a six-day intensive course on the subject of super-resolution microscopy in cooperation with Leica Microsystems.

New Leica TCS SP8 at Bates College: „Second of its kind in Maine, new microscope is a game-changer“


According to Bates College, the confocal offers new imaging capabilities and supports research in biology, neuroscience, nanotechnology and photophysics.

Free Infographic: Which Super-Resolution Microscopy Method is Right for You?


This illustrated guide to super-resolution microscopy helps you compare technologies to best fulfill your individual research needs.

The Scientist Top 10 Innovations Award for Leica TCS SP8 STED 3X


Leica Microsystems’ STED Super-Resolution Microscope Again Awarded for its Innovative Technology

Universal Hybrid Detector for Single Molecule Detection and Imaging at SfN and ASCB


Leica HyD SMD - the Optimal Detector for Precise and Reliable SMD data

Leica Microsystems Super-Resolution Products