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Leica Super-Resolution Microscopy: Collaborating with Nobel-Prize Winners

Super-resolution microscopy overcomes the diffraction limit of light and allows investigators to study subcellular structures in greater detail than is possible with a confocal microscope. Resolutions down to 20 nm are possible; in biology this represents the length of 10 average proteins end to end or 60 base pairs of DNA. With the introduction of the very first super-resolution microscope in 2004, and now our Leica TCS SP8 STED 3X and Leica SR GSD 3D, Leica Microsystems revolutionized opportunities for life science research allowing novel discoveries to be made in the fields of virology, neuroscience and cancer. True to the credo of Ernst Leitz ‘with the user, for the user’, Leica Microsystems has pioneered super-resolution by collaborating closely with leading scientists such as the Nobel Prize laureate Stefan Hell, as well as industry partners. This approach continuously improves the performance of our super-resolution microscopy systems. With 10 years of experience in the field, today we offer more than excellent products: Our commitment to high standards of service and support is also a key priority for Leica Microsystems.

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Super-Resolution Applications Beyond Limits

Leica SR GSD Application

Comparison of a 3D reconstruction of GSD and wide-field images. Mitochondrial ATP-Synthase in MDCK cells stained with anti-ATP-2B/Alexa647. The color code indicates the total height of the image. Courtesy of R. Jacob, Marburg, Germany (sample preparation).

Leica TCS SP8 STED 3X Application

Comparison of Confocal (red) and 3D STED data sets (green). Alpha Tubulin visualized with Oregon Green 488. Marine Dinoflagelatte Amphidinium spec. Data were deconvolved and surface rendered with Huygens (SVI). Courtesy of Elisa Berdalet, CSIC Institute of Marine Sciences/Timo Zimmermann, Center for Genomic Regulation, Barcelona, Spain.

Leica SR GSD 3D - The Evolution of Resolution

The Leica SR GSD 3D widefield super-resolution imaging system offers unparalleled abilities to study biological processes in multi dimensions beyond the diffraction barrier down to the molecular level.

  • Up to 10 times higher resolution in 3 dimensions
  • Simple multi-channel imaging capability
  • SuMo Stage delivers unprecedented stability
  • 160x objective optimized for use with high intensity lasers
  • Compatible with many standard fluorophores

Leica TCS SP8 STED 3X - Your Next Dimension

The Leica TCS SP8 STED 3X opens the door to fast, direct, and purely optical super-resolution over the full spectrum of visible light, in all dimensions.


Super Resolution Latest News

Visit Leica Microsystems’ booth #706 at the Microscience Microscopy Congress (MMC) 2015, June 30 to July 2, in Manchester

Advance Your Microscopy and Sample Preparation Knowledge Base at MMC 2015 in Manchester, UK

Free Hands-on Workshops and In-Booth Demonstrations

Visit Leica Microsystems’ booth #706 at the...

GSD Around the World – A Travel Diary on Facebook

Tamara Straube and Peter Laskey will take you on a journey around the world: Together with a team...

EMBL Advanced Course – Intensive Super-Resolution Microscopy Course for Localization Microscopy and STED

From 20th to 25th July 2015 the EMBL (European Molecular Biology Laboratory), Heidelberg will be...

Free Demo: Imaging Beyond Confocal Resolution

Pushing your confocal to its limits requires highly sensitive detection with low noise. Leica TCS...

Leica Microsystems Super-Resolution Products