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Leica Super-Resolution Microscopy: Collaborating with Nobel-Prize Winners

Super-resolution microscopy overcomes the diffraction limit of light and allows investigators to study subcellular structures in greater detail than is possible with a confocal microscope. Resolutions down to 20 nm are possible; in biology this represents the length of 10 average proteins end to end or 60 base pairs of DNA. With the introduction of the very first super-resolution microscope in 2004, and now our Leica TCS SP8 STED 3X and Leica SR GSD 3D, Leica Microsystems revolutionized opportunities for life science research allowing novel discoveries to be made in the fields of virology, neuroscience and cancer. True to the credo of Ernst Leitz ‘with the user, for the user’, Leica Microsystems has pioneered super-resolution by collaborating closely with leading scientists such as the Nobel Prize laureate Stefan Hell, as well as industry partners. This approach continuously improves the performance of our super-resolution microscopy systems. With 10 years of experience in the field, today we offer more than excellent products: Our commitment to high standards of service and support is also a key priority for Leica Microsystems.

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Super-Resolution Applications Beyond Limits

Comparison of a 3D reconstruction of GSD and wide-field images. Mitochondrial ATP-Synthase in MDCK cells stained with anti-ATP-2B/Alexa647. The color code indicates the total height of the image. Courtesy of R. Jacob, Marburg, Germany (sample preparation).

Comparison of Confocal (red) and 3D STED data sets (green). Alpha Tubulin visualized with Oregon Green 488. Marine Dinoflagelatte Amphidinium spec. Data were deconvolved and surface rendered with Huygens (SVI). Courtesy of Elisa Berdalet, CSIC Institute of Marine Sciences/Timo Zimmermann, Center for Genomic Regulation, Barcelona, Spain.

Leica SR GSD 3D - The Evolution of Resolution

The Leica SR GSD 3D widefield super-resolution imaging system offers unparalleled abilities to study biological processes in multi dimensions beyond the diffraction barrier down to the molecular level.

  • Up to 10 times higher resolution in 3 dimensions
  • Simple multi-channel imaging capability
  • SuMo Stage delivers unprecedented stability
  • 160x objective optimized for use with high intensity lasers
  • Compatible with many standard fluorophores

Leica TCS SP8 STED 3X - Your Next Dimension

The Leica TCS SP8 STED 3X opens the door to fast, direct, and purely optical super-resolution over the full spectrum of visible light, in all dimensions.


Super Resolution Latest News

Video Interview with Stefan Hell, the Inventor of Super-Resolution Microscopy

When we did this interview in June 2014, we hardly dared hope that Stefan Hell would be awarded the...

Nobel Prize for Inventor of Super-Resolution Microscopy Stefan Hell

October 10th, 2014

Collaboration With Leica Microsystems Made STED Microscopy Commercially...

Webinar: How to Pick the Right Microscopy Technique

Thursday, October 16th, 2014

In this webinar with Alison Dun you will learn about the variety of...

How Scientists Comment on 10 Years of Leica Super-Resolution Innovation

Julia Roberti, EMBL, Heidelberg, and Christopher Thrasivoulu, UCL, London

 

Leica Microsystems Super-Resolution Products

Leica TCS SP8 STED 3X Leica SR GSD 3D
Leica TCS SP8 STED 3X STED Super-Resolution. Your Next Dimension

STED (Stimulated Emission Depletion) microscopy provides fast, intuitive, and purely optical access to study subcellular architecture and dynamics at...

Leica SR GSD 3D Super-Resolution System for 3D Localization Microscopy

Widefield fluorescence microscope based on GSD (Ground State Depletion) or dSTORM (Direct STochastical Optical Reconstruction Microscopy) technology...