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DMi8 S Life Science Research

See more – Increase your viewing area up to 10,000x

Switch from searching image by image to seeing the full overview of your samples. Like a GPS for your cells, LAS X Navigator ensures that you always have a clear roadmap to brilliant data.

Create fast overviews of your samples and identify the important details instantly. Then set up high resolution image acquisition automatically using templates for slides, dishes and multiwell plates.

See more of the links you’ve been missing.

See faster – Experiments up to 5x faster

Find the missing links between your data points.

The Leica DMi8 S imaging system with LAS X Synapse software eliminates the bottlenecks between system components, resulting in dramatically faster imaging.

With an integrated real-time controller that directly interacts with all of your hardware components, cameras and peripherals, you can control your entire system with micro-second precision. Up to 5x faster time lapse experiments mean you can both save time and capture more details.

"The DMi8 S is a versatile and userfriendly system that empowers biomedical researchers to probe molecular machineries within the cell with super-resolution, photo-manipulation and optogenetics."

Dr. Alessandro Esposito, Hutchison MRC Research Centre, University of Cambridge, UK

See the hidden – Activate, ablate, and bleach in one experiment

Configure your Leica DMi8 S system to reveal more details in dynamic molecular processes. When you add the Infinity TIRF and Infinity Scanner to your system, you can perform applications like

  • TIRF
  • FRAP
  • Photoswitching
  • Ablation
  • Optogenetics
  • Super-resolution
  • Nanoscopy
U2OS cells stably expressing paGFP-H2B treated with Hoechst and photostimulated with 405nm laser. Overlay of two timepoints showing propagation of chromatin decondensation upon DNA damage from a single horizontal line. Courtesy of Dr. Rebecca Smith, Physiological Chemistry, Biomedical Center, Ludwig-Maximilians-University, Martinsried, Germany.
Create the ideal imaging system for your research and budget needs

DMi8 S – Modularity in widefield imaging

The DMi8 modular research microscope is the heart of the DMi8 S system. Fully configurable with manual to motorized components, you can create the ideal imaging system for your research and budget needs.  In addition, if your research needs to change, the system can also be adapted or upgraded at any time.

Every DMi8 microscope can be equipped with up to two Infinity Ports, allowing direct access into the fluorescent light path for addition of the latest in fluorescence technology, such as the Infinity Scanner or Infinity TIRF.

Contact us to find out how to upgrade your DMi8 to a DMi8 S system

Intelligent automation

Control every motorized component with the new LAS X Synapse real time controller and make sure you don't miss anything.

Make every component work in harmony, at the highest speed possible.

Standard experiments run up to 5x faster, use the latest camera technologies, and integrate third party triggered components. The best experiments start with intelligently designed electronics.

Leica DMi8 focus drive

The DMi8 system features closed loop focus with 20 nm re-positioning accuracy.

Combined with an increased focus travel range of 12 mm, choose closed loop focus for the highest repeatability with multi-point time lapse experiments. 

Leica Adaptive Focus Control

One click of a button and the LED light beam assisted Leica Adaptive Focus Control (AFC) automatically maintains your focus, in real time.

Save time and make sure your time lapse imaging isn’t affected by changes in experimental conditions.

Infinity Port

The Leica DMi8 is built with flexibility in mind. With up to two Infinity Ports providing access points for addition of fluorescent devices, the microscope is easily adaptable for everything from simple fluorescent imaging to sophisticated super resolution applications.

This novel design facilitates the integration of additional fluorescence light sources and laser systems for advanced applications like FRAP, photo-switching, ablation, optogenetics, and many more.


The Infinity Port Connector, along with complete optomechanical design documentation, opens the Leica DMi8 light path to any accessory you want to add.

Attach Thorlabs Cage Systems or Linos Microbench or Nanobench components directly to the Leica DMi8 by simply connecting them to the Infinity Port Connector.

Leaf from Solenostemon scutellarioides. Autofluorescence. Deconvolution. Leica DMi8 inverted life science research microscope equipped with a Leica DFC9000 GT High Speed High Resolution Monochrome Fluorescence sCMOS camera.

Optimized for sCMOS

Take full advantage of state-of-the-art large format sCMOS cameras.

The Leica DMi8 has an expanded 19mm field of view (FOV) for all camera ports.

In addition, see more through the eyepieces with up to 25 mm FOV.

Fluorescence imaging

The DMi8 features a host of fluorescence innovations.

For high speed imaging, use the external fluorescent filter wheels, or the patented Fluorescence Intensity Manager (FIM) to achieve fast, accurate fluorescent images.

For standard applications, use the easy to install filter cubes with automatic RFID identification.