Leica DM4 B & DM6 B 정립 현미경

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Fluorescence microscopy image of liver tissue where DNA in the nuclei are stained with Feulgen-pararosanilin and visualized with transmitted green light.

Epi-Illumination Fluorescence and Reflection-Contrast Microscopy

This article discusses the development of epi-illumination and reflection contrast for fluorescence microscopy concerning life-science applications. Much was done by the Ploem research group…
Neurons imaged with DIC contrast.

Differential Interference Contrast (DIC) Microscopy

This article demonstrates how differential interference contrast (DIC) can be actually better than brightfield illumination when using microscopy to image unstained biological specimens.
Image of MDCK (Madin-Darby canine kidney) cells taken with phase contrast.

Phase Contrast and Microscopy

This article explains phase contrast, an optical microscopy technique, which reveals fine details of unstained, transparent specimens that are difficult to see with common brightfield illumination.

Immersion Objectives

How an immersion objective, which has a liquid medium between it and the specimen being observed, helps increase the numerical aperture and microscope resolution is explained in this article.
Cellular polarization dynamics before and after magneto-mechanical stimulation

Mechanically Stressed Cells under the Microscope

Traumatic brain injury, skin scarring, or fibrotic heart remodeling are examples for mechanical stress which cells and tissues are exposed to. In this article, the authors introduce a non-invasive,…
When particulate contamination is present in lubricating fluids or oils, it can cause damage to parts or components leading to malfunctions.

Hydraulics in the Automotive and Aerospace Industries

Cleanliness standards relating to lubricants, hydraulic fluids, and oils, e.g., ISO 4406 and DIN 51455 are discussed in this article. Cleanliness plays a central role in the automotive and…
Mouse lung sections

Studying Pulmonary Fibrosis

The results shown in this article demonstrate that fibrotic and non-fibrotic regions of collagen present in mouse lung tissue can be distinguished better with polarized light compared to brightfield.…

Factors to Consider When Selecting a Research Microscope

An optical microscope is often one of the central devices in a life-science research lab. It can be used for various applications which shed light on many scientific questions. Thereby the…

The Fundamentals and History of Fluorescence and Quantum Dots

At some point in your research and science career, you will no doubt come across fluorescence microscopy. This ubiquitous technique has transformed the way in which microscopists can image, tag and…
Steps of Koehler Illumination

Koehler Illumination: A Brief History and a Practical Set Up in Five Easy Steps

The technique of Koehler Illumination is one of the most important and fundamental techniques in achieving optimum imaging in any given light microscope set-up. Although it should be routinely used as…
Left: Tissue cells marked with an immunolabel (FITC) illuminated with wide-band UV excitation. Note the tissue structure with blue autofluorescence. Right: Same tissue and same immunostaining with FITC label illuminated with epi-illumination using narrow-band blue (490 nm) light. Note the increased image contrast (Ploem, 1967)

Milestones in Incident Light Fluorescence Microscopy

Since the middle of the last century, fluorescence microscopy developed into a bio scientific tool with one of the biggest impacts on our understanding of life. Watching cells and proteins with the…
Center a fluorescence bulb.

Video Tutorial: How to Align the Bulb of a Fluorescence Lamp Housing

The traditional light source for fluorescence excitation is a fluorescence lamp housing with mercury burner. A prerequisite for achieving bright and homogeneous excitation is the correct centering and…
Exchange a fluorescence bulb.

Video Tutorial: How to Change the Bulb of a Fluorescence Lamp Housing

When applying fluorescence microscopy in biological applications, a lamp housing with mercury burner is the most common light source. This video tutorial shows how to change the bulb of a traditional…
Jellyfish Aequorea Victoria

Fluorescent Proteins - From the Beginnings to the Nobel Prize

Fluorescent proteins are the fundament of recent fluorescence microscopy and its modern applications. Their discovery and consequent development was one of the most exciting innovations for life…
Section taste buds rabbit, differential interference contrast microscope

Optical Contrast Methods

Optical contrast methods give the potential to easily examine living and colorless specimens. Different microscopic techniques aim to change phase shifts caused by the interaction of light with the…
Tartaric acids, polarization

Polarization Contrast

Polarization microscopy is routinely applied in material sciences and geology to identify minerals on the basis of characteristic refraction properties and colors. In biology, polarization microscopy…
Transgenic Mouse Embryo, GFP

Fluorescence in Microscopy

Fluorescence microscopy is a special form of light microscopy. It uses the ability of fluorochromes to emit light after being excited with light of a certain wavelength. Proteins of interest can be…
SPERM HY-LITER™ staining of a sexual assault smear slide performed by forensic DNA crime laboratory.

Forensic Detection of Sperm from Sexual Assault Evidence

The impact of modern scientific methods on the analysis of crime scene evidence has dramatically changed many forensic sub-specialties. Arguably one of the most dramatic examples is the impact of…

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형광 현미경법

형광은 주로 높은 감도와 높은 특이성 때문에 생물학적 및 분석적 현미경법에서 가장 일반적으로 사용되는 물리적 현상 중 하나입니다. 연구에 형광 현미경이 어떻게 활용될 수 있는지 확인해보세요.

바이러스 연구

연구의 관심 분야가 바이러스 감염과 질병에 집중되어 있습니까? 라이카마이크로시스템즈의 이미징 및 샘플 준비 솔루션을 통해 바이러스학에 관한 통찰력을 얻는 방법을 알아보세요.

기본 현미경 기술

기본 현미경 기술은 현미경 스테이지의 전체 표본이 광원에 노출되는 경우에 사용됩니다. 전체 시편은 위(거꾸로 구성) 또는 아래(표준 정립 현미경)에서 백색광으로 조명됩니다. 시료의 투명도와 대상 또는 관심 영역에 따라 관심 있는 복잡한 세포 구조를 구별하기 위해 다양한 형광 입자가 사용됩니다.

DIC 현미경

DIC 현미경은 광원과 콘덴서 렌즈 사이, 대물렌즈와 카메라 센서 또는 접안렌즈 사이에 편광 필터와 Wollaston 프리즘이 있는 광학 현미경입니다.

암시야 현미경

암시야 대비법은 재료 시료의 불균일한 특징부 또는 생물학적 표본의 구조로부터 광의 회절 또는 산란을 이용합니다.
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