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Leica DM6 FS Life Science Research

Outstanding Stability

Fixed Stage Microscope Leica DM6 FS

Do you work in a field such as electrophysiology, evolutionary biology, or neuroscience where outstanding stability is required for successful experiments? The Leica DM6 FS fixed stage fluorescence microscope is an ideal instrument for your present and future challenges!

  • Confidently perform your experiment with the highest degree of mechanical and electronic stability
  • Save time using the microscope’s full range of automated functions
  • Efficiently work with tools and accessories using special Leica optics that provide ample clearance around the specimen
  • Add special techniques based on the Leica DM6 FS for Optogenetics and Cryo CLEM
Leica DM6 FS fixed stage fluorescence microscope

Your Advantages

Stabilize Your Experiments Vibration-free Operation

Stabilize Your Experiments

Electrophysiological experiments are highly susceptible to external vibration and other interference. Any manipulation of a specimen can disrupt the axonal connections within the tissue slice or the acquired patch-clamp configuration.

The electronic design of the Leica DM6 FS stabilizes your experiments:

  • Conveniently control the full system without touching the hardware
  • All motors and current-carrying elements are switched off if not in use

The compact design of the instrument makes it mechanically stable as well, and creates space for accessories to be used on the microscope’s stage.

Vibration-free Operation

Operate the microscope smoothly using the remote control. The motorized objective changer prevents disruption of your sample by swapping two objectives in a vibration-free manner.

  • Switch magnification without touching the microscope
  • Change objectives or gently immerse an objective into the buffer solution
Ample Clearance Easily Customize Your Set-Up

Ample Clearance

Choose from a range of special objectives featuring extra-long free working distance, a large access angle, and an inert ceramic front with minimal electric and thermal conductivity for electrophysiology.

  • Use the Leica HC FLUOTAR L 25x/0.95 W VISIR objective from our series of high-end objectives especially designed for near-infrared DIC
  • Open the visual field for good clearance around the specimen with an access angle of 41°and a large free working distance of 2.5 mm 
  • Penetrate into very thick tissue with unrivalled clear contrast and high resolution using Wollaston prisms for Differential Interference Contrast (DIC)

Easily Customize Your Set-Up

Configure your objectives in three different ways and combine all of these with three different motorized magnification changers.

  • On a 6-position motorized nosepiece
  • On a 2-position motorized objective changer
  • On a single objective holder

You can switch optically between magnifications during an experiment without changing the objective at all by combining a magnification changer with low magnification – high numerical aperture objectives.

Optogenetics Solutions Correlative Light and Electron Microscopy

Optogenetics Solutions

Optogenetics is a quickly evolving manipulation technique. It utilizes photosensitive proteins to trigger cellular processes. The Leica DM6 FS is the perfect platform for your optogenetics system, which allows you to efficiently manipulate your cells.

  • Select the light source suited for your application – powerful LEDs in a wide wavelength range
  • Your choice – digital micro-mirror device (DMD)-based illumination or illumination that covers the entire field of view

Find more details about Optogenetics in the Leica Science Lab article

Correlative Light and Electron Microscopy

The Leica DM6 FS is also a platform for the Leica EM Cryo CLEM system, which facilitates correlative light and electron microscopy (CLEM).

  • Benefit from the full system solution: a fluorescence light microscope with cryo stage, cryo objective, and a cryo transfer shuttle
  • Quickly determine which regions of interest you would like to investigate in the electron microscope
  • Maintain cryo-fixed specimens under precise cryo conditions during imaging in the fluorescence light microscope and during transfer

Read more about Cryo CLEM in the Science Lab article