STELLARIS 8 DIVE Microscópios confocais Produtos Página inicial Leica Microsystems

A microscopia multifotônica multicolorida o aproxima da verdade

Microscópio multifotônico STELLARIS 8 DIVE

Extracellular Matrix in Synthetic Hydrogel-Based Prostate Cancer Organoids Regulate Therapeutic Response to EZH2 and DRD2 Inhibitors
Mosquera MJ, Kim S, Bareja R, Fang Z, Cai S, Pan H, Asad M, Martin ML, Sigouros M, Rowdo FM, Ackermann S, Capuano J, Bernheim J, Cheung C, Doane A, Brady N, Singh R, Rickman DS, Prabhu V, Allen JE, Puca L, Coskun AF, Rubin MA, Beltran H, Mosquera JM, Elemento O, Singh A.
Adv Mater, 2022
DOI: 10.1002/adma.202100096

Intravital imaging reveals glomerular capillary distension and endothelial and immune cell activation early in Alport syndrome
Gyarmati G, Shroff UN, Izuhara A, Hou X, Da Sacco S, Sedrakyan S, Lemley KV, Amann K, Perin L, Peti-Peterdi J.
JCI Insight, 2022
DOI: 10.1172/jci.insight.152676

In Vivo Developmental Trajectories of Human Podocyte Inform In Vitro Differentiation of Pluripotent Stem Cell-Derived Podocytes
Enrico A, Voulgaris D, Östmans R, Sundaravadivel N, Moutaux L, Cordier A, Niklaus F, Herland A, Stemme G.
Adv Mater, 2022.
DOI: 10.1002/adma.202109823

Primary germinal center-resident T follicular helper cells are a physiologically distinct subset of CXCR5(hi)PD-1(hi) T follicular helper cells
Yeh CH, Finney J, Okada T, Kurosaki T, Kelsoe G
Immunity, 2022
DOI: 10.1016/j.immuni.2021.12.015

A conductive photothermal non-swelling nanocomposite hydrogel patch accelerating bone defect repair
Li Y, He J, Zhou J, Li Z, Liu L, Hu S, Guo B, Wang W.
Biomater Sci, 2022
DOI: 10.1039/d1bm01937f

Changes in intrathoracic pressure, not arterial pulsations, exert the greatest effect on tracer influx in the spinal cord
Liu S, Bilston LE, Flores Rodriguez N, Wright C, McMullan S, Lloyd R, Stoodley MA, Hemley SJ.
Fluids Barriers CNS, 2022
DOI: 10.1186/s12987-022-00310-6

Subcellular localization of hippocampal ryanodine receptor 2 and its role in neuronal excitability and memory
Hiess F, Yao J, Song Z, Sun B, Zhang Z, Huang J, Chen L, Institoris A, Estillore JP, Wang R, Ter Keurs HEDJ, Stys PK, Gordon GR, Zamponi GW, Ganguly A, Chen SRW.
Commun Biol, 2022.
DOI: 10.1038/s42003-022-03124-2

Fine Tuning of Multiphoton AIE Emission Behavior, Organelle Targeting, and Fluorescence Lifetime Imaging of Terpyridine Derivatives by Alkyl Chain Engineering
Wang S, Lin Y, Zhang C, Zhu T, Tian X, Li D, Ma W, Zhang Q, Wu J, Tian Y.
Anal Chem, 2022
DOI: 10.1021/acs.analchem.1c05052

Endothelial Unc5B controls blood-brain barrier integrity
Boyé K, Geraldo LH, Furtado J, Pibouin-Fragner L, Poulet M, Kim D, Nelson B, Xu Y, Jacob L, Maissa N, Agalliu D, Claesson-Welsh L, Ackerman SL, Eichmann A.
Nat Commun, 2022
DOI: 10.1038/s41467-022-28785-9

A comprehensive enhancer screen identifies TRAM2 as a key and novel mediator of YAP oncogenesis
Li L, Ugalde AP, Scheele CLGJ, Dieter SM, Nagel R, Ma J, Pataskar A, Korkmaz G, Elkon R, Chien MP, You L, Su PR, Bleijerveld OB, Altelaar M, Momchev L, Manber Z, Han R, van Breugel PC, Lopes R, Ten Dijke P, van Rheenen J, Agami R.
Genome Biol, 2021
DOI: 10.1186/s13059-021-02272-8

Group 1 innate lymphoid-cell-derived interferon-γ maintains anti-viral vigilance in the mucosal epithelium
Shannon JP, Vrba SM, Reynoso GV, Wynne-Jones E, Kamenyeva O, Malo CS, Cherry CR, McManus DT, Hickman HD.
Immunity, 2021
DOI: 10.1016/j.immuni.2020.12.004

Primordial GATA6 macrophages function as extravascular platelets in sterile injury
Zindel J, Peiseler M, Hossain M, Deppermann C, Lee WY, Haenni B, Zuber B, Deniset JF, Surewaard BGJ, Candinas D, Kubes P.
Science, 2021
DOI: 10.1126/science.abe0595

Graft-derived extracellular vesicles transported across subcapsular sinus macrophages elicit B cell alloimmunity after transplantation
Zeng F, Chen Z, Chen R, Shufesky WJ, Bandyopadhyay M, Camirand G, Oberbarnscheidt MH, Sullivan MLG, Baty CJ, Yang MQ, Calderon M, Stolz DB, Erdos G, Pelanda R, Brennan TV, Catz SD, Watkins SC, Larregina AT, Morelli AE.
Sci Transl Med, 2021
DOI: 10.1126/scitranslmed.abb0122

The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis
Fidler TP, Xue C, Yalcinkaya M, Hardaway B, Abramowicz S, Xiao T, Liu W, Thomas DG, Hajebrahimi MA, Pircher J, Silvestre-Roig C, Kotini AG, Luchsinger LL, Wei Y, Westerterp M, Snoeck HW, Papapetrou EP, Schulz C, Massberg S, Soehnlein O, Ebert B, Levine RL, Reilly MP, Libby P, Wang N, Tall AR.
Nature, 2021
DOI: 10.1038/s41586-021-03341-5

Quantitative imaging of intracellular nanoparticle exposure enables prediction of nanotherapeutic efficacy
Wang Z, Gurlo T, Matveyenko AV, Elashoff D, Wang P, Rosenberger M, Junge JA, Stevens RC, White KL, Fraser SE, Butler PC.
Nat Commun, 2021
DOI: 10.1038/s41467-021-22678-z

Live-cell imaging of glucose-induced metabolic coupling of β and α cell metabolism in health and type 2 diabetes
Z. Wang, T. Gurlo, A. V. Matveyenko, D. Elashoff, P. Wang, M. Rosenberger, J. A. Junge, R. C. Stevens, K. L. White, S. E. Fraser & P. C. Butler
Commun Biol, 2021
DOI: 10.1038/s42003-021-02113-1

Age-related changes in the local milieu of inflamed tissues cause aberrant neutrophil trafficking and subsequent remote organ damage
Barkaway A, Rolas L, Joulia R, Bodkin J, Lenn T, Owen-Woods C, Reglero-Real N, Stein M, Vázquez-Martínez L, Girbl T, Poston RN, Golding M, Saleeb RS, Thiriot A, von Andrian UH, Duchene J, Voisin MB, Bishop CL, Voehringer D, Roers A, Rot A, Lämmermann T, Nourshargh S.
Immunity, 2021
DOI: 10.1016/j.immuni.2021.04.025

A neural crest cell isotropic-to-nematic phase transition in the developing mammalian gut
Chevalier NR, Ammouche Y, Gomis A, Langlois L, Guilbert T, Bourdoncle P, Dufour S.
Commun Biol, 2021
DOI: 10.1038/s42003-021-02333-5

SLIT2/ROBO signaling in tumor-associated microglia and macrophages drives glioblastoma immunosuppression and vascular dysmorphia
Geraldo LH, Xu Y, Jacob L, Pibouin-Fragner L, Rao R, Maissa N, Verreault M, Lemaire N, Knosp C, Lesaffre C, Daubon T, Dejaegher J, Solie L, Rudewicz J, Viel T, Tavitian B, De Vleeschouwer S, Sanson M, Bikfalvi A, Idbaih A, Lu QR, Lima FR, Thomas JL, Eichmann A, Mathivet T.
J Clin Invest, 2021
DOI: 10.1172/JCI141083

Carbon Dots with Absorption Red-Shifting for Two-Photon Fluorescence Imaging of Tumor Tissue pH and Synergistic Phototherapy
Bai Y, Zhao J, Wang S, Lin T, Ye F, Zhao S.
ACS Appl Mater Interfaces, 2021
DOI: 10.1021/acsami.1c08076

Profiling Cisplatin Resistance in Head and Neck Cancer: A Critical Role of the VRAC Ion Channel for Chemoresistance
Siemer S, Fauth T, Scholz P, Al-Zamel Y, Khamis A, Gül D, Freudelsperger L, Wollenberg B, Becker S, Stauber RH, Hagemann J.
Cancers (Basel), 2021
DOI: 10.3390/cancers13194831

Structure dynamics of HIV-1 Env trimers on native virions engaged with living T cells
Carlon-Andres I, Malinauskas T, Padilla-Parra S.
Commun Biol, 2021
DOI: 10.1038/s42003-021-02658-1

Targeting Cancer Chemotherapy Resistance by Precision Medicine-Driven Nanoparticle-Formulated Cisplatin
Siemer S, Bauer TA, Scholz P, Breder C, Fenaroli F, Harms G, Dietrich D, Dietrich J, Rosenauer C, Barz M, Becker S, Strieth S, Reinhardt C, Fauth T, Hagemann J, Stauber RH.
ACS Nano, 2021
DOI: 10.1021/acsnano.1c08632

Distinct contributions of partial and full EMT to breast cancer malignancy
Lüönd F, Sugiyama N, Bill R, Bornes L, Hager C, Tang F, Santacroce N, Beisel C, Ivanek R, Bürglin T, Tiede S, van Rheenen J, Christofori G.
Dev Cell, 2021
DOI: 10.1016/j.devcel.2021.11.006

Blood-brain barrier-restricted translocation of Toxoplasma gondii from cortical capillaries
Olivera GC, Ross EC, Peuckert C, Barragan A.
Elife, 2021
DOI: 10.7554/eLife.69182

Visualizing polymeric components that define distinct root barriers across plant lineages
Sexauer M, Shen D, Schön M, Andersen TG, Markmann K.
Development, 2021
DOI: 10.1242/dev.199820

A comprehensive enhancer screen identifies TRAM2 as a key and novel mediator of YAP oncogenesis
Li L, Ugalde AP, Scheele CLGJ, Dieter SM, Nagel R, Ma J, Pataskar A, Korkmaz G, Elkon R, Chien MP, You L, Su PR, Bleijerveld OB, Altelaar M, Momchev L, Manber Z, Han R, van Breugel PC, Lopes R, Ten Dijke P, van Rheenen J, Agami R.
Genome Biol, 2021
DOI: 10.1186/s13059-021-02272-8

Primordial GATA6 macrophages function as extravascular platelets in sterile injury
Zindel J, Peiseler M, Hossain M, Deppermann C, Lee WY, Haenni B, Zuber B, Deniset JF, Surewaard BGJ, Candinas D, Kubes P.
Science, 2021
DOI: 10.1126/science.abe0595

Live-cell imaging of glucose-induced metabolic coupling of β and α cell metabolism in health and type 2 diabetes
Wang Z, Gurlo T, Matveyenko AV, Elashoff D, Wang P, Rosenberger M, Junge JA, Stevens RC, White KL, Fraser SE, Butler PC.
Commun Biol, 2021
DOI: 10.1038/s42003-021-02113-1

Long-Term Cell Fate Tracking of Individual Renal Cells Using Serial Intravital Microscopy
Schiessl IM, Fremter K, Burford JL, Castrop H, Peti-Peterdi J.
Methods Mol Biol, 2020
DOI: 10.1007/7651_2019_232

Estimation of the Mitochondrial Membrane Potential Using Fluorescence Lifetime Imaging Microscopy
Okkelman IA, Papkovsky DB, Dmitriev RI.
Cytometry A, 2020
DOI: 10.1002/cyto.a.23886

Dissection of heterocellular cross-talk in vascularized cardiac tissue mimetics
Wagner JUG, Pham MD, Nicin L, Hammer M, Bottermann K, Yuan T, Sharma R, John D, Muhly-Reinholz M, Tombor L, Hardt M, Madl J, Dimmeler S, Krishnan J.
J Mol Cell Cardiol, 2020
DOI: 10.1016/j.yjmcc.2019.12.005

Single-cell glycolytic activity regulates membrane tension and HIV-1 fusion
Coomer CA, Carlon-Andres I, Iliopoulou M, Dustin ML, Compeer EB, Compton AA, Padilla-Parra S.
PLoS Pathog, 2020
DOI: 10.1371/journal.ppat.1008359

Plasticity of Lgr5-Negative Cancer Cells Drives Metastasis in Colorectal Cancer
Fumagalli A, Oost KC, Kester L, Morgner J, Bornes L, Bruens L, Spaargaren L, Azkanaz M, Schelfhorst T, Beerling E, Heinz MC, Postrach D, Seinstra D, Sieuwerts AM, Martens JWM, van der Elst S, van Baalen M, Bhowmick D, Vrisekoop N, Ellenbroek SIJ, Suijkerbuijk SJE, Snippert HJ, van Rheenen J.
Cell Stem Cell, 2020
DOI: 10.1016/j.stem.2020.02.008

Glomerular endothelial cell heterogeneity in Alport syndrome
Soloyan H, Thornton M, Villani V, Khatchadourian P, Cravedi P, Angeletti A, Grubbs B, De Filippo R, Perin L, Sedrakyan S.
Sci Rep, 2020
DOI: 10.1038/s41598-020-67588-0

Sinoatrial Node Structure, Mechanics, Electrophysiology and the Chronotropic Response to Stretch in Rabbit and Mouse
MacDonald EA, Madl J, Greiner J, Ramadan AF, Wells SM, Torrente AG, Kohl P, Rog-Zielinska EA, Quinn TA.
Front Physiol, 2020
DOI: 10.3389/fphys.2020.00809

Reproducibility and staging of 3D human retinal organoids across multiple pluripotent stem cell lines
Capowski EE, Samimi K, Mayerl SJ, Phillips MJ, Pinilla I, Howden SE, Saha J, Jansen AD, Edwards KL, Jager LD, Barlow K, Valiauga R, Erlichman Z, Hagstrom A, Sinha D, Sluch VM, Chamling X, Zack DJ, Skala MC, Gamm DM.
Development, 2019
DOI: 10.1242/dev.171686

Targeted drug delivery via caveolae-associated protein PV1 improves lung fibrosis
Marchetti GM, Burwell TJ, Peterson NC, Cann JA, Hanna RN, Li Q, Ongstad EL, Boyd JT, Kennedy MA, Zhao W, Rickert KW, Grimsby JS, Dall'Acqua WF, Wu H, Tsui P, Borrok MJ, Gupta R.
Commun Biol, 2019
DOI: 10.1038/s42003-019-0337-2

In Vivo Developmental Trajectories of Human Podocyte Inform In Vitro Differentiation of Pluripotent Stem Cell-Derived Podocytes
Tran T, Lindström NO, Ransick A, De Sena Brandine G, Guo Q, Kim AD, Der B, Peti-Peterdi J, Smith AD, Thornton M, Grubbs B, McMahon JA, McMahon AP.
Dev Cell, 2019
DOI: 10.1016/j.devcel.2019.06.001

Novel fluorescence techniques to quantitate renal cell biology
Shroff UN, Schiessl IM, Gyarmati G, Riquier-Brison A, Peti-Peterdi J.
Methods Cell Biol, 2019
DOI: 10.1016/bs.mcb.2019.04.013

Peritoneal GATA6+ macrophages function as a portal for Staphylococcus aureus dissemination
Jorch SK, Surewaard BG, Hossain M, Peiseler M, Deppermann C, Deng J, Bogoslowski A, van der Wal F, Omri A, Hickey MJ, Kubes P.
J Clin Invest, 2019
DOI: 10.1172/JCI127286