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  • Science Lab Topic: EM Sample Preparation

    Immersion Freezing for Cryo-Transmission Electron Microscopy: Applications

    A well established usage case for cryo-TEM is three-dimensional reconstruction of isolated macromolecules, virus particles, or filaments. On one hand, these approaches are based on averaging of…
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  • Science Lab Topic: EM Sample Preparation

    Immersion Freezing for Cryo-Transmission Electron Microscopy: Fundamentals

    The high vacuum required in a transmission electron microscope (TEM) greatly impairs the ability to study specimens naturally occurring in an aqueous phase: exposing "wet" specimens to a pressure…
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