Pesquisa em Ciências da Vida

Alzheimer's disease, a genetic and sporadic neurodegenerative condition, leads to cognitive decline in mid to late life, marked by β-amyloid plaques and tau tangles. With limited treatment options, new investigative strategies are crucial. The Cell DIVE multiplexed imaging solution allows examination of Alzheimer's brain tissue, potentially uncovering new research avenues. Here, we showcase the Cell DIVE image viewer, enabling users to access the full Alzheimer's multiplexed dataset directly in their browser.

This interview highlights the transformative impact of Mica at Imperial College London. Scientists explain how Mica has been a game-changer, expanding research possibilities and facilitating interdisciplinary collaboration. They explain how detailed live cell imaging with Mica provides more meaningful information, keeping scientists at the forefront of research. The team foresees Mica continuing to open new research avenues, including the study of microfluidics and other advanced applications.

In the webinar entitled "A Multimodal Vitreous Crusade, a Cryo Correlative Workflow from Bench to Beam" a team of experts discusses the exciting world of correlative workflows for structural biology that empower researchers to study fine details of biological structures. Watch and explore the latest developments, instruments, and techniques in cryo workflows for correlative light electron microscopy (cryo-CLEM).

O câncer é uma doença complexa e heterogênea causada por células com deficiência na regulação do crescimento. Mudanças genéticas e epigenéticas em uma ou em um grupo de células prejudicam o funcionamento normal e resultam em um crescimento celular descontrolado e na proliferação.

Pancreatic cancer, with a mortality rate near 40%, is challenging to treat due to its proximity to major organs. This story explores the complex biology of pancreatic ductal adenocarcinoma (PDAC), examining molecular and spatial determinants of tumor aggression in metabolism, apoptosis, and immunity. Access the full Cell DIVE dataset in your browser to delve deeper into these findings.

Colorectal cancer poses a significant health burden. While surgery is effective initially, some patients develop recurrent secondary disease with poor prognosis, necessitating advanced therapies like immunotherapies. Spatial biology approaches, such as multiplexed imaging with Cell DIVE, can provide crucial insights for developing novel treatments. Access the full Cell DIVE dataset in your browser to explore these findings further through the Minerva image viewer.

This article provides an introduction to the recommendations of 21 CFR Part 11 from the FDA, specifically focusing on the audit trail and user management in the context of cell-culture laboratories. It is intended for professionals in the biotechnology and pharmaceutical industries who are responsible for ensuring agreement with 21 CFR part 11 for electronic records and electronic signatures. A digital microscope approach, e.g. with Mateo FL, offers the advantage of more consistent and efficient electronic documentation of cell-culture results compared to a paper-based method.

Você pode passar muitas horas olhando através de oculares de um microscópio de dissecação sempre que for necessário realizar dissecações. A Leica Microsystems permite que você escolha entre uma série diversa de microscópios e uma ampla gama de peças e acessórios de microscópios de dissecação, para que você possa encontrar a solução de microscopia certa para atender às suas necessidades.

Você está trabalhando rumo a uma melhor compreensão de doenças neurodegenerativas ou estudando a função do sistema nervoso? Veja como você pode fazer descobertas com as soluções de aquisição de imagens da Leica Microsystems.

Spatial mapping of untreated tumors provides an overview of the tumor immune architecture, useful for understanding therapeutic responses. Immunocompetent murine models are essential for identifying immune-dependent events in tumor development and progression. Characterizing these models, with intact immune systems and interacting cellular components, requires a multiplexed approach. We show an AI-powered spatial proteomics approach to study the tumor-immune interactions in murine cancer tissue.

Soluções para aquisição de imagens e preparação de amostras para pesquisas em virologia

A tomografia crioeletrônica (CryoET) é usada para resolver biomoléculas dentro de seu ambiente celular até uma resolução sem precedentes, abaixo de um nanômetro.

Para os melhores resultados durante a verificação, triagem, manipulação e aquisição de imagem, você precisa ver osdetalhes e estruturas que permitem tomar as decisões certas para os próximos passos em sua pesquisa. Conhecidos por sua ótica surpreendente e resolução magnífica, os estereomicroscópios e bases de luz transmitidas da Leica são a escolha preferida de pesquisadores ao redor do mundo.

Block-face created by automatic trimming under fluorescence. Mammalian cells of interest, stained with CellTrackerTM Green are visualized within the block-face using the UC Enuity equipped with the stereo microscope M205 FA. In the background a carbon finder grid in black is visible.

Despite the availability of imaging methods and mass spectroscopy for spatial proteomics, a key challenge that remains is correlating images with single-cell resolution to protein-abundance measurements. Deep Visual Proteomics (DVP), a recent method, combines artificial-intelligence-driven image analysis of cellular phenotypes with automated single-cell or single-nucleus laser microdissection and ultra-high-sensitivity mass spectrometry. DVP links protein abundance to complex cellular or subcellular phenotypes while preserving spatial context.