Conocimiento al detalle de la biología celular estructural
Criomicroscopios ópticos THUNDER Imager EM Cryo CLEM
![[Translate to spanish:]](https://webcdn.leica-microsystems.com/fileadmin/_processed_/5/e/csm_lms-life-science-fluorescence-header_d87141576b.jpg "Microscopía de fluorescencia")
Microscopía de fluorescencia
La fluorescencia es uno de los fenómenos físicos más utilizados en la microscopía biológica y analítica, principalmente por su alta sensibilidad y alta especificidad. Averigüe cómo los microscopios de…
Read article
![[Translate to spanish:]](https://webcdn.leica-microsystems.com/fileadmin/_processed_/5/c/csm_lms-life-science-billboard-subpages-header_cell-cultur-01_39b9064e5b.jpg "Cultivo celular")
Cultivo celular
Cultivar células en condiciones de laboratorio es la base del trabajo de los científicos en campos como la biología celular, la investigación del cáncer, la biología del desarrollo y cualquier otra…
Read article
Investigación del cáncer
El cáncer es una enfermedad compleja y heterogénea causada por células con una regulación deficiente del crecimiento. Los cambios genéticos y epigenéticos en una célula o en un grupo de ellas alteran…
Read article
![[Translate to spanish:] Leica Cell Biology](https://webcdn.leica-microsystems.com/fileadmin/_processed_/a/8/csm_cell-biology-3-2_ee0a834d15.jpg "Biología celular")
Biología celular
Descubra cómo puede extraer el máximo rendimiento a sus investigaciones en materia de biología celular y amplíe sus descubrimientos con las soluciones de generación de imágenes de Leica Microsystems.
Read article
Virología
¿Su interés en investigación se centra en infecciones víricas y enfermedades? Descubra cómo puede adquirir conocimientos sobre virología con soluciones de generación de imágenes y preparación de…
Read article
Organismos modelo en la investigación
Un organismo modelo es una especia empleada por los investigadores para estudiar procesos biológicos específicos. Sus características genéticas son similares a las de los humanos y se emplean de forma…
Read article
Science Lab Topic:
EM Sample Preparation
Download EM Workflow Solutions Booklet
This publication is a compilation of appropriate workflows for the most frequently used sample preparation methods, like Correlative Methodologies, Optogenetics & Electro-Physiology, Surface Analysis,…
Read article
Science Lab Topic:
EM Sample Preparation
Exploring the Structure and Life Cycle of Viruses
The SARS-CoV-2 outbreak started in late December 2019 and has since reached a global pandemic, leading to a worldwide battle against COVID-19. The ever-evolving electron microscopy methods offer a…
Read article
Science Lab Topic:
CLEM
Targeting Active Recycling Nuclear Pore Complexes using Cryo Confocal Microscopy
In this article, how cryo light microscopy and, in particular cryo confocal microscopy, is used to improve the reliability of cryo EM workflows is described. The quality of the EM grids and samples is…
Read article
Science Lab Topic:
CLEM
Advancing Cell Biology with Cryo-Correlative Microscopy
Correlative light and electron microscopy (CLEM) advances biological discoveries by merging different microscopes and imaging modalities to study systems in 4D. Combining fluorescence microscopy with…
Read article
Science Lab Topic:
EM Sample Preparation
Workflows and Instrumentation for Cryo-electron Microscopy
Cryo-electron microscopy is an increasingly popular modality to study the structures of macromolecular complexes and has enabled numerous new insights in cell biology. In recent years, cryo-electron…
Read article
Science Lab Topic:
Widefield Microscopy
An Introduction to Computational Clearing
Many software packages include background subtraction algorithms to enhance the contrast of features in the image by reducing background noise. The most common methods used to remove background noise…
Read article
Science Lab Topic:
EM Sample Preparation
Coronavirus Replication in Host Cells
In this study, a molecular pore complex, which spans both membranes of SARS-CoV-2/COVID-19 virus-induced cytosolic vesicles and likely plays a role in replication, was visualized.
Read article
Science Lab Topic:
CLEM
Crystal clear cryo light-microscopy images
This article describes how computational clearing of cryo light microscopy images improves the identification of cellular targets for cryo electron-microscopy.
Read article
Science Lab Topic:
Widefield Microscopy
THUNDER Technology Note
So far, widefield microscopy was not suitable to image larger volumes, since the contrast of the recorded fluorescence image is reduced by the background (BG) mainly originating from out of focus…
Read article
