THUNDER Imager EM Cryo CLEM Sistemas de imagen THUNDER Productos Inicio Leica Leica Microsystems
  • [Translate to spanish:]

    Microscopía de fluorescencia

    La fluorescencia es uno de los fenómenos físicos más utilizados en la microscopía biológica y analítica, principalmente por su alta sensibilidad y alta especificidad. Averigüe cómo los microscopios de…
    Read article
  • [Translate to spanish:]

    Cultivo celular

    Cultivar células en condiciones de laboratorio es la base del trabajo de los científicos en campos como la biología celular, la investigación del cáncer, la biología del desarrollo y cualquier otra…
    Read article
  • Investigación del cáncer

    El cáncer es una enfermedad compleja y heterogénea causada por células con una regulación deficiente del crecimiento. Los cambios genéticos y epigenéticos en una célula o en un grupo de ellas alteran…
    Read article
  • [Translate to spanish:] Leica Cell Biology

    Biología celular

    Descubra cómo puede extraer el máximo rendimiento a sus investigaciones en materia de biología celular y amplíe sus descubrimientos con las soluciones de generación de imágenes de Leica Microsystems.
    Read article
  • Virología

    ¿Su interés en investigación se centra en infecciones víricas y enfermedades? Descubra cómo puede adquirir conocimientos sobre virología con soluciones de generación de imágenes y preparación de…
    Read article
  • Organismos modelo en la investigación

    Un organismo modelo es una especia empleada por los investigadores para estudiar procesos biológicos específicos. Sus características genéticas son similares a las de los humanos y se emplean de forma…
    Read article
  • 3D reconstruction of an intercellular bridge in a C. elegans embryo
    Science Lab Topic: EM Sample Preparation

    Download EM Workflow Solutions Booklet

    This publication is a compilation of appropriate workflows for the most frequently used sample preparation methods, like Correlative Methodologies, Optogenetics & Electro-Physiology, Surface Analysis,…
    Read article
  • Science Lab Topic: EM Sample Preparation

    Exploring the Structure and Life Cycle of Viruses

    The SARS-CoV-2 outbreak started in late December 2019 and has since reached a global pandemic, leading to a worldwide battle against COVID-19. The ever-evolving electron microscopy methods offer a…
    Read article
  • Cryo FIB lamella - Overlay of SEM and confocal fluorescence image
    Science Lab Topic: CLEM

    Targeting Active Recycling Nuclear Pore Complexes using Cryo Confocal Microscopy

    In this article, how cryo light microscopy and, in particular cryo confocal microscopy, is used to improve the reliability of cryo EM workflows is described. The quality of the EM grids and samples is…
    Read article
  • Science Lab Topic: CLEM

    Advancing Cell Biology with Cryo-Correlative Microscopy

    Correlative light and electron microscopy (CLEM) advances biological discoveries by merging different microscopes and imaging modalities to study systems in 4D. Combining fluorescence microscopy with…
    Read article
  • Science Lab Topic: EM Sample Preparation

    Workflows and Instrumentation for Cryo-electron Microscopy

    Cryo-electron microscopy is an increasingly popular modality to study the structures of macromolecular complexes and has enabled numerous new insights in cell biology. In recent years, cryo-electron…
    Read article
  • Science Lab Topic: Widefield Microscopy

    An Introduction to Computational Clearing

    Many software packages include background subtraction algorithms to enhance the contrast of features in the image by reducing background noise. The most common methods used to remove background noise…
    Read article
  • Science Lab Topic: EM Sample Preparation

    Coronavirus Replication in Host Cells

    In this study, a molecular pore complex, which spans both membranes of SARS-CoV-2/COVID-19 virus-induced cytosolic vesicles and likely plays a role in replication, was visualized.
    Read article
  • Science Lab Topic: CLEM

    Crystal clear cryo light-microscopy images

    This article describes how computational clearing of cryo light microscopy images improves the identification of cellular targets for cryo electron-microscopy.
    Read article
  • Science Lab Topic: Widefield Microscopy

    THUNDER Technology Note

    So far, widefield microscopy was not suitable to image larger volumes, since the contrast of the recorded fluorescence image is reduced by the background (BG) mainly originating from out of focus…
    Read article