Workshop: Preserving Cellular Detail

Preserving Cellular Detail: Integrated Cryo-Techniques for High-Throughput Microscopy

Explore the Future of Sample Preservation and Imaging

Traditional chemical fixation methods often fall short—introducing artifacts and compromising the integrity of biological samples. This hands-on workshop introduces advanced cryo-techniques that preserve cellular architecture with fidelity, enabling high-throughput 3D imaging workflows .

Join us to discover how high-pressure freezing (HPF), freeze substitution (FS), and precision sectioning with the UC Enuity ultramicrotome are reshaping the landscape of structural biology and biomedical research .

What You’ll Learn

• Why HPF is a game-changer: Understand how vitrification preserves native cellular structures without chemical artifacts .
• Freeze substitution workflows: Learn how FS bridges cryo-preservation with downstream imaging and labeling techniques.
• Hybrid approaches: Explore workflows combining immunogold labeling, correlative microscopy, and cryo-techniques.
• Hands-on with the UC Enuity: Get introduced to Leica’s next-generation ultramicrotome, designed for intuitive use , precision cutting , and increased throughput.
• Workflow integration: See how these tools and techniques come together to support high-throughput, reproducible imaging pipelines.

Who Should Attend

This workshop is ideal for:

• Researchers in structural biology, cell biology, and biomedical imaging
• Lab technicians and microscopists seeking to optimize sample prep workflows
• Anyone interested in integrating cryo-techniques into high-throughput imaging pipelines

Save your seat and take the next step in mastering modern microscopy