THUNDER Imager EM Cryo CLEM THUNDER Imaging Systems Produits Accueil Leica Leica Microsystems
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    Microscopie Fluorescente

    La fluorescence est l'un des phénomènes physiques les plus couramment utilisés en microscopie biologique et analytique, principalement en raison de sa grande sensibilité et de sa haute spécificité.…
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  • [Translate to french:]

    Culture cellulaire

    La culture de cellules en laboratoire constitue la base des travaux des scientifiques spécialisés dans les domaines de la biologie cellulaire, la recherche contre le cancer, la biologie du…
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  • Recherche sur le cancer

    Le cancer est une maladie complexe et hétérogène causée par des cellules déficientes dans la régulation de la croissance. Les modifications génétiques et épigénétiques d’une cellule ou d’un groupe de…
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  • [Translate to french:] Leica Cell Biology

    Biologie cellulaire

    Découvrez comment vous pouvez tirer le meilleur parti de vos recherches en biologie cellulaire et élargir vos découvertes grâce aux solutions d’imagerie de Leica Microsystems.
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  • Virologie

    Vos recherches portent sur les infections et les maladies virales ? Découvrez comment renforcer vos connaissances en virologie grâce aux solutions d’imagerie et de préparation d’échantillons de Leica…
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  • Organismes modèles dans la recherche

    Un organisme modèle désigne une espèce utilisée par les chercheurs pour étudier des processus biologiques spécifiques. Ils présentent des caractéristiques génétiques similaires à celles de l’homme et…
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  • 3D reconstruction of an intercellular bridge in a C. elegans embryo
    Science Lab Topic: EM Sample Preparation

    Download EM Workflow Solutions Booklet

    This publication is a compilation of appropriate workflows for the most frequently used sample preparation methods, like Correlative Methodologies, Optogenetics & Electro-Physiology, Surface Analysis,…
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  • Science Lab Topic: EM Sample Preparation

    Exploring the Structure and Life Cycle of Viruses

    The SARS-CoV-2 outbreak started in late December 2019 and has since reached a global pandemic, leading to a worldwide battle against COVID-19. The ever-evolving electron microscopy methods offer a…
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  • Cryo FIB lamella - Overlay of SEM and confocal fluorescence image
    Science Lab Topic: CLEM

    Targeting Active Recycling Nuclear Pore Complexes using Cryo Confocal Microscopy

    In this article, how cryo light microscopy and, in particular cryo confocal microscopy, is used to improve the reliability of cryo EM workflows is described. The quality of the EM grids and samples is…
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  • Science Lab Topic: CLEM

    Advancing Cell Biology with Cryo-Correlative Microscopy

    Correlative light and electron microscopy (CLEM) advances biological discoveries by merging different microscopes and imaging modalities to study systems in 4D. Combining fluorescence microscopy with…
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  • Science Lab Topic: EM Sample Preparation

    Workflows and Instrumentation for Cryo-electron Microscopy

    Cryo-electron microscopy is an increasingly popular modality to study the structures of macromolecular complexes and has enabled numerous new insights in cell biology. In recent years, cryo-electron…
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  • Science Lab Topic: Widefield Microscopy

    An Introduction to Computational Clearing

    Many software packages include background subtraction algorithms to enhance the contrast of features in the image by reducing background noise. The most common methods used to remove background noise…
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  • Science Lab Topic: EM Sample Preparation

    Coronavirus Replication in Host Cells

    In this study, a molecular pore complex, which spans both membranes of SARS-CoV-2/COVID-19 virus-induced cytosolic vesicles and likely plays a role in replication, was visualized.
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  • Science Lab Topic: CLEM

    Crystal clear cryo light-microscopy images

    This article describes how computational clearing of cryo light microscopy images improves the identification of cellular targets for cryo electron-microscopy.
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  • Science Lab Topic: Widefield Microscopy

    THUNDER Technology Note

    So far, widefield microscopy was not suitable to image larger volumes, since the contrast of the recorded fluorescence image is reduced by the background (BG) mainly originating from out of focus…
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