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2022

The APC/C targets the Cep152-Cep63 complex at the centrosome to regulate mitotic spindle assembly
Tischer T, Yang J, Barford D.
J Cell Sci, 2022
DOI: 10.1242/jcs.259273

Engineered HaloTag variants for fluorescence lifetime multiplexing
Frei MS, Tarnawski M, Roberti MJ, Koch B, Hiblot J, Johnsson K.
Nat Methods, 2022
DOI: 10.1038/s41592-021-01341-x

Platelet SHARPIN regulates platelet adhesion and inflammatory responses through associations with αIIbβ3 and LUBAC
Kasirer-Friede A, Peuhu E, Ivaska J, Shattil SJ.
Blood Adv, 2022
DOI: 10.1182/bloodadvances.2021005611

Organization and dynamics of the cortical complexes controlling insulin secretion in β-cells
Noordstra I, van den Berg CM, Boot FWJ, Katrukha EA, Yu KL, Tas RP, Portegies S, Viergever BJ, de Graaff E, Hoogenraad CC, de Koning EJP, Carlotti F, Kapitein LC, Akhmanova A.
J Cell Sci, 2022
DOI: 10.1242/jcs.259430

Nanoscale dynamics of actin filaments in the red blood cell membrane skeleton
Nowak RB, Alimohamadi H, Pestonjamasp K, Rangamani P, Fowler VM.
Mol Biol Cell, 2022
DOI: 10.1091/mbc.E21-03-0107

Microtubule organizing centers regulate spindle positioning in mouse oocytes
Londoño-Vásquez D, Rodriguez-Lukey K, Behura SK, Balboula AZ.
Dev Cell, 2022
DOI: 10.1016/j.devcel.2021.12.011

The ESCRT machinery directs quality control over inner nuclear membrane architecture
Shankar R, Lettman MM, Whisler W, Frankel EB, Audhya A.
Cell Rep, 2022
DOI: 10.1016/j.celrep.2021.110263

Recognition and inhibition of SARS-CoV-2 by humoral innate immunity pattern recognition molecules
Stravalaci M, Pagani I, Paraboschi EM, Pedotti M, Doni A, Scavello F, Mapelli SN, Sironi M, Perucchini C, Varani L, Matkovic M, Cavalli A, Cesana D, Gallina P, Pedemonte N, Capurro V, Clementi N, Mancini N, Invernizzi P, Bayarri-Olmos R, Garred P, Rappuoli R, Duga S, Bottazzi B, Uguccioni M, Asselta R, Vicenzi E, Mantovani A, Garlanda C.
Nat Immunol, 2022
DOI: 10.1038/s41590-021-01114-w

The interplay between BAX and BAK tunes apoptotic pore growth to control mitochondrial-DNA-mediated inflammation
Cosentino K, Hertlein V, Jenner A, Dellmann T, Gojkovic M, Peña-Blanco A, Dadsena S, Wajngarten N, Danial JSH, Thevathasan JV, Mund M, Ries J, Garcia-Saez AJ.
Mol Cell, 2022
DOI: 10.1016/j.molcel.2022.01.008

Plectin-mediated cytoskeletal crosstalk controls cell tension and cohesion in epithelial sheets
Prechova M, Adamova Z, Schweizer AL, Maninova M, Bauer A, Kah D, Meier-Menches SM, Wiche G, Fabry B, Gregor M.
J Cell Biol, 2022
DOI: 10.1083/jcb.202105146

Mitochondrial fusion regulates proliferation and differentiation in the type II neuroblast lineage in Drosophila
Dubal D, Moghe P, Verma RK, Uttekar B, Rikhy R.
PLoS Genet, 2022
DOI: 10.1371/journal.pgen.1010055

Uip4p modulates nuclear pore complex function in Saccharomyces cerevisiae
Deolal P, Jamir I, Mishra K.
Nucleus, 2022
DOI: 10.1080/19491034.2022.2034286

Rebuilding essential active zone functions within a synapse
Tan C, Wang SSH, de Nola G, Kaeser PS.
Neuron, 2022
DOI: 10.1016/j.neuron.2022.01.026

Nanoscale rules governing the organization of glutamate receptors in spine synapses are subunit specific
Hruska M, Cain RE, Dalva MB.
Nat Commun, 2022
DOI: 10.1038/s41467-022-28504-4

Visualizing cellular and tissue ultrastructure using Ten-fold Robust Expansion Microscopy (TREx)
Damstra HGJ, Mohar B, Eddison M, Akhmanova A, Kapitein LC, Tillberg PW.
Elife, 2022
DOI: 10.7554/eLife.73775

Sulfonated red and far-red rhodamines to visualize SNAP- and Halo-tagged cell surface proteins
Birke R, Ast J, Roosen DA, Lee J, Roßmann K, Huhn C, Mathes B, Lisurek M, Bushiri D, Sun H, Jones B, Lehmann M, Levitz J, Haucke V, Hodson DJ, Broichhagen J.
Org Biomol Chem, 2022
DOI: 10.1039/d1ob02216d

2021

Autophagy alleviates hypoxia-induced blood-brain barrier injury via regulation of CLDN5 (claudin 5)
Yang Z, Lin P, Chen B, Zhang X, Xiao W, Wu S, Huang C, Feng D, Zhang W, Zhang J.
Autophagy, 2021
DOI: 10.1080/15548627.2020.1851897

Cytoneme delivery of Sonic Hedgehog from ligand-producing cells requires Myosin 10 and a Dispatched-BOC/CDON co-receptor complex
Hall ET, Dillard ME, Stewart DP, Zhang Y, Wagner B, Levine RM, Pruett-Miller SM, Sykes A, Temirov J, Cheney RE, Mori M, Robinson CG, Ogden SK.
Elife, 2021
DOI: 10.7554/eLife.61432

Actin cables and comet tails organize mitochondrial networks in mitosis
Moore AS, Coscia SM, Simpson CL, Ortega FE, Wait EC, Heddleston JM, Nirschl JJ, Obara CJ, Guedes-Dias P, Boecker CA, Chew TL, Theriot JA, Lippincott-Schwartz J, Holzbaur ELF.
Nature, 2021
DOI: 10.1038/s41586-021-03309-5

Rab2 regulates presynaptic precursor vesicle biogenesis at the trans-Golgi
Götz TWB, Puchkov D, Lysiuk V, Lützkendorf J, Nikonenko AG, Quentin C, Lehmann M, Sigrist SJ, Petzoldt AG.
J Cell Biol, 2021
DOI: 10.1083/jcb.202006040

Lipid-mediated motor-adaptor sequestration impairs axonal lysosome delivery leading to autophagic stress and dystrophy in Niemann-Pick type C
Roney JC, Li S, Farfel-Becker T, Huang N, Sun T, Xie Y, Cheng XT, Lin MY, Platt FM, Sheng ZH.
Dev Cell, 2021
DOI: 10.1016/j.devcel.2021.03.032

Engineering T cells to enhance 3D migration through structurally and mechanically complex tumor microenvironments
Tabdanov ED, Rodríguez-Merced NJ, Cartagena-Rivera AX, Puram VV, Callaway MK, Ensminger EA, Pomeroy EJ, Yamamoto K, Lahr WS, Webber BR, Moriarity BS, Zhovmer AS, Provenzano PP.
Nat Commun, 2021
DOI: 10.1038/s41467-021-22985-5

PKC-phosphorylation of Liprin-α3 triggers phase separation and controls presynaptic active zone structure
Emperador-Melero J, Wong MY, Wang SSH, de Nola G, Nyitrai H, Kirchhausen T, Kaeser PS.
Nat Commun, 2021
DOI: 10.1038/s41467-021-23116-w

Three-dimensional residual channel attention networks denoise and sharpen fluorescence microscopy image volumes
Chen J, Sasaki H, Lai H, Su Y, Liu J, Wu Y, Zhovmer A, Combs CA, Rey-Suarez I, Chang HY, Huang CC, Li X, Guo M, Nizambad S, Upadhyaya A, Lee SJ, Lucas LAG, Shroff H.
Nat Methods, 2021
DOI: 10.1038/s41592-021-01155-x

Shear forces induce ICAM-1 nanoclustering on endothelial cells that impact on T-cell migration
Piechocka IK, Keary S, Sosa-Costa A, Lau L, Mohan N, Stanisavljevic J, Borgman KJE, Lakadamyali M, Manzo C, Garcia-Parajo MF.
Biophys J, 2021
DOI: 10.1016/j.bpj.2021.05.016

Mechano-induced cell metabolism promotes microtubule glutamylation to force metastasis
Torrino S, Grasset EM, Audebert S, Belhadj I, Lacoux C, Haynes M, Pisano S, Abélanet S, Brau F, Chan SY, Mari B, Oldham WM, Ewald AJ, Bertero T.
Cell Metab, 2021
DOI: 10.1016/j.cmet.2021.05.009

The subcellular arrangement of alpha-synuclein proteoforms in the Parkinson's disease brain as revealed by multicolor STED microscopy
Moors TE, Maat CA, Niedieker D, Mona D, Petersen D, Timmermans-Huisman E, Kole J, El-Mashtoly SF, Spycher L, Zago W, Barbour R, Mundigl O, Kaluza K, Huber S, Hug MN, Kremer T, Ritter M, Dziadek S, Geurts JJG, Gerwert K, Britschgi M, van de Berg WDJ.
Acta Neuropathol, 2021
DOI: 10.1007/s00401-021-02329-9

A large-scale nanoscopy and biochemistry analysis of postsynaptic dendritic spines
Helm MS, Dankovich TM, Mandad S, Rammner B, Jähne S, Salimi V, Koerbs C, Leibrandt R, Urlaub H, Schikorski T, Rizzoli SO.
Nat Neurosci, 2021
DOI: 10.1038/s41593-021-00874-w

HepaCAM controls astrocyte self-organization and coupling
Baldwin KT, Tan CX, Strader ST, Jiang C, Savage JT, Elorza-Vidal X, Contreras X, Rülicke T, Hippenmeyer S, Estévez R, Ji RR, Eroglu C.
Neuron, 2021
DOI: 10.1016/j.neuron.2021.05.025

A Golgi-derived vesicle potentiates PtdIns4P to PtdIns3P conversion for endosome fission
Gong B, Guo Y, Ding S, Liu X, Meng A, Li D, Jia S.
Nat Cell Biol, 2021
DOI: 10.1038/s41556-021-00704-y

GABA-receptive microglia selectively sculpt developing inhibitory circuits
Favuzzi E, Huang S, Saldi GA, Binan L, Ibrahim LA, Fernández-Otero M, Cao Y, Zeine A, Sefah A, Zheng K, Xu Q, Khlestova E, Farhi SL, Bonneau R, Datta SR, Stevens B, Fishell G.
Cell, 2021
DOI: 10.1016/j.cell.2021.06.018

Super-resolution microscopy reveals that Na(+)/K(+)-ATPase signaling protects against glucose-induced apoptosis by deactivating Bad
Bernhem K, Fontana JM, Svensson D, Zhang L, Nilsson LM, Scott L, Blom H, Brismar H, Aperia A.
Cell Death Dis, 2021
DOI: 10.1038/s41419-021-04025-8

Probing the spatiotemporal patterns of HBV multiplication reveals novel features of its subcellular processes
Yue L, Li C, Xu M, Wu M, Ding J, Liu J, Zhang X, Yuan Z.
PLoS Pathog, 2021
DOI: 10.1371/journal.ppat.1009838

Preformed Ω-profile closure and kiss-and-run mediate endocytosis and diverse endocytic modes in neuroendocrine chromaffin cells
Shin W, Wei L, Arpino G, Ge L, Guo X, Chan CY, Hamid E, Shupliakov O, Bleck CKE, Wu LG.
Neuron, 2021
DOI: 10.1016/j.neuron.2021.07.019

Datopotamab Deruxtecan, a Novel TROP2-directed Antibody-drug Conjugate, Demonstrates Potent Antitumor Activity by Efficient Drug Delivery to Tumor Cells
Okajima D, Yasuda S, Maejima T, Karibe T, Sakurai K, Aida T, Toki T, Yamaguchi J, Kitamura M, Kamei R, Fujitani T, Honda T, Shibutani T, Muramatsu S, Nakada T, Goto R, Takahashi S, Yamaguchi M, Hamada H, Noguchi Y, Murakami M, Abe Y, Agatsuma T.
Mol Cancer Ther, 2021
DOI: 10.1158/1535-7163.MCT-21-0206

Cilium induction triggers differentiation of glioma stem cells
Goranci-Buzhala G, Mariappan A, Ricci-Vitiani L, Josipovic N, Pacioni S, Gottardo M, Ptok J, Schaal H, Callaini G, Rajalingam K, Dynlacht B, Hadian K, Papantonis A, Pallini R, Gopalakrishnan J.
Cell Rep, 2021
DOI: 10.1016/j.celrep.2021.109656

The Atypical Cyclin-Dependent Kinase 5 (Cdk5) Guards Podocytes from Apoptosis in Glomerular Disease While Being Dispensable for Podocyte Development
Mangold N, Pippin J, Unnersjoe-Jess D, Koehler S, Shankland S, Brähler S, Schermer B, Benzing T, Brinkkoetter PT, Hagmann H.
Cells, 2021
DOI: 10.3390/cells10092464

Multiomics of synaptic junctions reveals altered lipid metabolism and signaling following environmental enrichment
Borgmeyer M, Coman C, Has C, Schött HF, Li T, Westhoff P, Cheung YFH, Hoffmann N, Yuanxiang P, Behnisch T, Gomes GM, Dumenieu M, Schweizer M, Chocholoušková M, Holčapek M, Mikhaylova M, Kreutz MR, Ahrends R.
Cell Rep, 2021
DOI: 10.1016/j.celrep.2021.109797

An uncommon neuronal class conveys visual signals from rods and cones to retinal ganglion cells
Young BK, Ramakrishnan C, Ganjawala T, Wang P, Deisseroth K, Tian N.
Proc Natl Acad Sci U S A, 2021
DOI: 10.1073/pnas.2104884118

Phosphatidylserine receptors enhance SARS-CoV-2 infection
Bohan D, Van Ert H, Ruggio N, Rogers KJ, Badreddine M, Aguilar Briseño JA, Elliff JM, Rojas Chavez RA, Gao B, Stokowy T, Christakou E, Kursula P, Micklem D, Gausdal G, Haim H, Minna J, Lorens JB, Maury W.
PLoS Pathog, 2021
DOI: 10.1371/journal.ppat.1009743

Engineering of a fluorescent chemogenetic reporter with tunable color for advanced live-cell imaging
Benaissa H, Ounoughi K, Aujard I, Fischer E, Goïame R, Nguyen J, Tebo AG, Li C, Le Saux T, Bertolin G, Tramier M, Danglot L, Pietrancosta N, Morin X, Jullien L, Gautier A.
Nat Commun, 2021
DOI: 10.1038/s41467-021-27334-0

Super-Resolution Microscopy Using a Bioorthogonal-Based Cholesterol Probe Provides Unprecedented Capabilities for Imaging Nanoscale Lipid Heterogeneity in Living Cells
Lorizate M, Terrones O, Nieto-Garai JA, Rojo-Bartolomé I, Ciceri D, Morana O, Olazar-Intxausti J, Arboleya A, Martin A, Szynkiewicz M, Calleja-Felipe M, Bernardino de la Serna J, Contreras FX.
Small Methods, 2021
DOI: 10.1002/smtd.202100430

Astroglial ER-mitochondria calcium transfer mediates endocannabinoid-dependent synaptic integration
Serrat R, Covelo A, Kouskoff V, Delcasso S, Ruiz-Calvo A, Chenouard N, Stella C, Blancard C, Salin B, Julio-Kalajzić F, Cannich A, Massa F, Varilh M, Deforges S, Robin LM, De Stefani D, Busquets-Garcia A, Gambino F, Beyeler A, Pouvreau S, Marsicano G.
Cell Rep, 2021
DOI: 10.1016/j.celrep.2021.110133

Pseudomonas aeruginosa rhamnolipid micelles deliver toxic metabolites and antibiotics into Staphylococcus aureus
Gdaniec BG, Bonini F, Prodon F, Braschler T, Köhler T, van Delden C.
iScience, 2021
DOI: 10.1016/j.isci.2021.103669

Caveolae-mediated Tie2 signaling contributes to CCM pathogenesis in a brain endothelial cell-specific Pdcd10-deficient mouse model
Zhou HJ, Qin L, Jiang Q, Murray KN, Zhang H, Li B, Lin Q, Graham M, Liu X, Grutzendler J, Min W.
Nat Commun, 2021
DOI: 10.1038/s41467-020-20774-0

The SARS-CoV-2 nucleocapsid phosphoprotein forms mutually exclusive condensates with RNA and the membrane-associated M protein
Lu S, Ye Q, Singh D, Cao Y, Diedrich JK, Yates JR 3rd, Villa E, Cleveland DW, Corbett KD.
Nat Commun, 2021
DOI: 10.1038/s41467-020-20768-y

Heritable pattern of oxidized DNA base repair coincides with pre-targeting of repair complexes to open chromatin
Bacolla A, Sengupta S, Ye Z, Yang C, Mitra J, De-Paula RB, Hegde ML, Ahmed Z, Mort M, Cooper DN, Mitra S, Tainer JA.
Nucleic Acids Res, 2021
DOI: 10.1093/nar/gkaa1120

Drosophila female germline stem cells undergo mitosis without nuclear breakdown
Duan T, Cupp R, Geyer PK.
Curr Biol, 2021
DOI: 10.1016/j.cub.2021.01.033

High-resolution imaging reveals compartmentalization of mitochondrial protein synthesis in cultured human cells
Zorkau M, Albus CA, Berlinguer-Palmini R, Chrzanowska-Lightowlers ZMA, Lightowlers RN.
PNAS, 2021
DOI: 10.1073/pnas.2008778118

LGI1-ADAM22-MAGUK configures transsynaptic nanoalignment for synaptic transmission and epilepsy prevention
Fukata Y, Chen X, Chiken S, Hirano Y, Yamagata A, Inahashi H, Sanbo M, Sano H, Goto T, Hirabayashi M, Kornau HC, Prüss H, Nambu A, Fukai S, Nicoll RA, Fukata M.
PNAS, 2021
DOI: 10.1073/pnas.2022580118

Centriole and PCM cooperatively recruit CEP192 to spindle poles to promote bipolar spindle assembly
Chinen T, Yamazaki K, Hashimoto K, Fujii K, Watanabe K, Takeda Y, Yamamoto S, Nozaki Y, Tsuchiya Y, Takao D, Kitagawa D.
J Cell Biol, 2021
DOI: 10.1083/jcb.202006085

Superresolution characterization of core centriole architecture
Tian Y, Wei C, He J, Yan Y, Pang N, Fang X, Liang X, Fu J.
J Cell Biol, 2021
DOI: 10.1083/jcb.202005103

NIX initiates mitochondrial fragmentation via DRP1 to drive epidermal differentiation
Simpson CL, Tokito MK, Uppala R, Sarkar MK, Gudjonsson JE, Holzbaur ELF.
Cell Rep, 2021
DOI: 10.1016/j.celrep.2021.108689

Stochastic asymmetric repartition of lytic machinery in dividing CD8(+) T cells generates heterogeneous killing behavior
Lafouresse F, Jugele R, Müller S, Doineau M, Duplan-Eche V, Espinosa E, Puisségur MP, Gadat S, Valitutti S.
Elife, 2021
DOI: 10.7554/eLife.62691

TRIM37 prevents formation of centriolar protein assemblies by regulating Centrobin
Balestra FR, Domínguez-Calvo A, Wolf B, Busso C, Buff A, Averink T, Lipsanen-Nyman M, Huertas P, Ríos RM, Gönczy P.
Elife, 2021
DOI: 10.7554/eLife.62640

Cabozantinib Unlocks Efficient In Vivo Targeted Delivery of Neutrophil-Loaded Nanoparticles into Murine Prostate Tumors
Chaudagar KK, Landon-Brace N, Solanki A, Hieromnimon HM, Hegermiller E, Li W, Shao Y, Joseph J, Wilkins DJ, Bynoe KM, Li XL, Clohessy JG, Ullas S, Karp JM, Patnaik A.
Mol Cancer Ther, 2021
DOI: 10.1158/1535-7163.MCT-20-0167

Neural tube closure requires the endocytic receptor Lrp2 and its functional interaction with intracellular scaffolds
Kowalczyk I, Lee C, Schuster E, Hoeren J, Trivigno V, Riedel L, Görne J, Wallingford JB, Hammes A, Feistel K.
Development, 2021
DOI: 10.1242/dev.195008

The nuclear lamina is a hub for the nuclear function of Jacob
Samer S, Raman R, Laube G, Kreutz MR, Karpova A.
Mol Brain, 2021
DOI: 10.1186/s13041-020-00722-1

SLX4IP Promotes Telomere Maintenance in Androgen Receptor-Independent Castration-Resistant Prostate Cancer through ALT-like Telomeric PML Localization
Mangosh TL, Awadallah WN, Grabowska MM, Taylor DJ.
Mol Cancer Res, 2021
DOI: 10.1158/1541-7786.MCR-20-0314

EFA6A, an exchange factor for Arf6, regulates early steps in ciliogenesis
Partisani M, Baron CL, Ghossoub R, Fayad R, Pagnotta S, Abélanet S, Macia E, Brau F, Lacas-Gervais S, Benmerah A, Luton F, Franco M.
J Cell Sci, 2021
DOI: 10.1242/jcs.249565

Intercellular and intracellular cilia orientation is coordinated by CELSR1 and CAMSAP3 in oviduct multiciliated cells
Usami FM, Arata M, Shi D, Oka S, Higuchi Y, Tissir F, Takeichi M, Fujimori T.
J Cell Sci, 2021
DOI: 10.1242/jcs.257006

2020

The FUS gene is dual-coding with both proteins contributing to FUS-mediated toxicity
Brunet MA, Jacques JF, Nassari S, Tyzack GE, McGoldrick P, Zinman L, Jean S, Robertson J, Patani R, Roucou X.
EMBO Rep, 2020
DOI: 10.15252/embr.202050640

LEM2 phase separation promotes ESCRT-mediated nuclear envelope reformation
von Appen A, LaJoie D, Johnson IE, Trnka MJ, Pick SM, Burlingame AL, Ullman KS, Frost A.
Nature, 2020
DOI: 10.1038/s41586-020-2232-x

Thermus thermophilus Argonaute Functions in the Completion of DNA Replication
Jolly SM, Gainetdinov I, Jouravleva K, Zhang H, Strittmatter L, Bailey SM, Hendricks GM, Dhabaria A, Ueberheide B, Zamore PD.
Cell, 2020
DOI: 10.1016/j.cell.2020.07.036

A general strategy to develop cell permeable and fluorogenic probes for multicolour nanoscopy
Wang L, Tran M, D'Este E, Roberti J, Koch B, Xue L, Johnsson K.
Nat Chem, 2020
DOI: 10.1038/s41557-019-0371-1

Microglia and macrophages promote corralling, wound compaction and recovery after spinal cord injury via Plexin-B2
Zhou X, Wahane S, Friedl MS, Kluge M, Friedel CC, Avrampou K, Zachariou V, Guo L, Zhang B, He X, Friedel RH, Zou H.
Nat Neurosci, 2020
DOI: 10.1038/s41593-020-0597-7

Cell stretching is amplified by active actin remodelling to deform and recruit proteins in mechanosensitive structures
Massou S, Nunes Vicente F, Wetzel F, Mehidi A, Strehle D, Leduc C, Voituriez R, Rossier O, Nassoy P, Giannone G.
Nat Cell Biol, 2020
DOI: 10.1038/s41556-020-0548-2

Mitochondrial RNA granules are fluid condensates positioned by membrane dynamics
Rey T, Zaganelli S, Cuillery E, Vartholomaiou E, Croisier M, Martinou JC, Manley S.
Nat Cell Biol, 2020
DOI: 10.1038/s41556-020-00584-8

Combination of metabolic intervention and T cell therapy enhances solid tumor immunotherapy
Hao M, Hou S, Li W, Li K, Xue L, Hu Q, Zhu L, Chen Y, Sun H, Ju C, Zhang C.
Sci Transl Med, 2020
DOI: 10.1126/scitranslmed.aaz6667

Cholesterol in the Viral Membrane is a Molecular Switch Governing HIV-1 Env Clustering
Nieto-Garai JA, Arboleya A, Otaegi S, Chojnacki J, Casas J, Fabriàs G, Contreras FX, Kräusslich HG, Lorizate M.
Adv Sci, 2020
DOI: 10.1002/advs.202003468

Arginine-Enriched Mixed-Charge Domains Provide Cohesion for Nuclear Speckle Condensation
Greig JA, Nguyen TA, Lee M, Holehouse AS, Posey AE, Pappu RV, Jedd G.
Mol Cell, 2020
DOI: 10.1016/j.molcel.2020.01.025

Regulation of Phosphoribosyl-Linked Serine Ubiquitination by Deubiquitinases DupA and DupB
Shin D, Mukherjee R, Liu Y, Gonzalez A, Bonn F, Liu Y, Rogov VV, Heinz M, Stolz A, Hummer G, Dötsch V, Luo ZQ, Bhogaraju S, Dikic I.
Mol Cell, 2020
DOI: 10.1016/j.molcel.2019.10.019

The Nuclear Matrix Protein SAFB Cooperates with Major Satellite RNAs to Stabilize Heterochromatin Architecture Partially through Phase Separation
Huo X, Ji L, Zhang Y, Lv P, Cao X, Wang Q, Yan Z, Dong S, Du D, Zhang F, Wei G, Liu Y, Wen B.
Mol Cell, 2020
DOI: 10.1016/j.molcel.2019.10.001

In Situ, Noncovalent Labeling and Stimulated Emission Depletion-Based Super-Resolution Imaging of Supramolecular Peptide Nanostructures
Kumar M, Son J, Huang RH, Sementa D, Lee M, O'Brien S, Ulijn RV.
ACS Nano, 2020
DOI: 10.1021/acsnano.0c05029

Neural Stem Cells Direct Axon Guidance via Their Radial Fiber Scaffold
Kaur N, Han W, Li Z, Madrigal MP, Shim S, Pochareddy S, Gulden FO, Li M, Xu X, Xing X, Takeo Y, Li Z, Lu K, Imamura Kawasawa Y, Ballester-Lurbe B, Moreno-Bravo JA, Chédotal A, Terrado J, Pérez-Roger I, Koleske AJ, Sestan N.
Neuron, 2020
DOI: 10.1016/j.neuron.2020.06.035

Artificial regulation of state transition for augmenting plant photosynthesis using synthetic light-harvesting polymer materials
Zhou X, Zeng Y, Tang Y, Huang Y, Lv F, Liu L, Wang S.
Sci Adv, 2020
DOI: 10.1126/sciadv.abc5237

MCART1/SLC25A51 is required for mitochondrial NAD transport
Kory N, Uit de Bos J, van der Rijt S, Jankovic N, Güra M, Arp N, Pena IA, Prakash G, Chan SH, Kunchok T, Lewis CA, Sabatini DM.
Sci Adv, 2020
DOI: 10.1126/sciadv.abe5310

Ribosome-associated vesicles: A dynamic subcompartment of the endoplasmic reticulum in secretory cells
Carter SD, Hampton CM, Langlois R, Melero R, Farino ZJ, Calderon MJ, Li W, Wallace CT, Tran NH, Grassucci RA, Siegmund SE, Pemberton J, Morgenstern TJ, Eisenman L, Aguilar JI, Greenberg NL, Levy ES, Yi E, Mitchell WG, Rice WJ, Wigge C, Pilli J, George EW, Aslanoglou D, Courel M, Freyberg RJ, Javitch JA, Wills ZP, Area-Gomez E, Shiva S, Bartolini F, Volchuk A, Murray SA, Aridor M, Fish KN, Walter P, Balla T, Fass D, Wolf SG, Watkins SC, Carazo JM, Jensen GJ, Frank J, Freyberg Z.
Sci Adv, 2020
DOI: 10.1126/sciadv.aay9572

The chaperonin CCT controls T cell receptor-driven 3D configuration of centrioles
Martin-Cofreces NB, Chichon FJ, Calvo E, Torralba D, Bustos-Moran E, Dosil SG, Rojas-Gomez A, Bonzon-Kulichenko E, Lopez JA, Otón J, Sorrentino A, Zabala JC, Vernos I, Vazquez J, Valpuesta JM, Sanchez-Madrid F.
Sci Adv, 2020
DOI: 10.1126/sciadv.abb7242

A Multi-responsive Fluorescent Probe Reveals Mitochondrial Nucleoprotein Dynamics with Reactive Oxygen Species Regulation through Super-resolution Imaging
Yang G, Liu Z, Zhang R, Tian X, Chen J, Han G, Liu B, Han X, Fu Y, Hu Z, Zhang Z.
Angew Chem Int Ed Engl, 2020
DOI: 10.1002/anie.202005959

Designing Sub-2 nm Organosilica Nanohybrids for Far-Field Super-Resolution Imaging
Liang L, Yan W, Qin X, Peng X, Feng H, Wang Y, Zhu Z, Liu L, Han Y, Xu Q, Qu J, Liu X.
Angew Chem Int Ed Engl, 2020
DOI: 10.1002/anie.201912404

Endosome motility defects revealed at super-resolution in live cells using HIDE probes
Gupta A, Rivera-Molina F, Xi Z, Toomre D, Schepartz A.
Nat Chem Biol, 2020
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ORANGE: A CRISPR/Cas9-based genome editing toolbox for epitope tagging of endogenous proteins in neurons
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Improving Brightness and Stability of Si-Rhodamine for Super-Resolution Imaging of Mitochondria in Living Cells
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A novel water-soluble quinoline-indole derivative as a three-photon fluorescent probe for identifying nucleolus RNA and mitochondrial DNA
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The K219T-Lamin mutation induces conduction defects through epigenetic inhibition of SCN5A in human cardiac laminopathy
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ZFYVE21 is a complement-induced Rab5 effector that activates non-canonical NF-κB via phosphoinosotide remodeling of endosomes
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Loss of the ribosomal RNA methyltransferase NSUN5 impairs global protein synthesis and normal growth
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Cancer-Cell-Membrane-Coated Nanoparticles with a Yolk-Shell Structure Augment Cancer Chemotherapy
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Kinesin-3 Responds to Local Microtubule Dynamics to Target Synaptic Cargo Delivery to the Presynapse
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Imaging within single NPCs reveals NXF1's role in mRNA export on the cytoplasmic side of the pore
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Tks5 and Dynamin-2 enhance actin bundle rigidity in invadosomes to promote myoblast fusion
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Structural evidence for a new elaborate 3D-organization of the cardiomyocyte lateral membrane in adult mammalian cardiac tissues
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EGFR Signaling Termination via Numb Trafficking in Ependymal Progenitors Controls Postnatal Neurogenic Niche Differentiation
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Presynaptic Endosomal Cathepsin D Regulates the Biogenesis of GABAergic Synaptic Vesicles
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The E3 Ubiquitin Ligase Mind Bomb 1 Controls Adenovirus Genome Release at the Nuclear Pore Complex
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Three-Dimensional Genomic Structure and Cohesin Occupancy Correlate with Transcriptional Activity during Spermatogenesis
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Radial somatic F-actin organization affects growth cone dynamics during early neuronal development
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Viral M45 and necroptosis-associated proteins form heteromeric amyloid assemblies
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An integrin/MFG-E8 shuttle loads HIV-1 viral-like particles onto follicular dendritic cells in mouse lymph node
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Arp2/3 complex-driven spatial patterning of the BCR enhances immune synapse formation, BCR signaling and B cell activation
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Reconstruction of Par-dependent polarity in apolar cells reveals a dynamic process of cortical polarization
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Release of cholesterol-rich particles from the macrophage plasma membrane during movement of filopodia and lamellipodia
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Transient protein accumulation at the center of the T cell antigen-presenting cell interface drives efficient IL-2 secretion
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Reticulon and CLIMP-63 regulate nanodomain organization of peripheral ER tubules
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Dynamic organization of Herpesvirus glycoproteins on the viral envelope revealed by super-resolution microscopy
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The TLR4 adaptor TRAM controls the phagocytosis of Gram-negative bacteria by interacting with the Rab11-family interacting protein 2
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PLoS Pathog, 2019
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ESCRT-III is necessary for the integrity of the nuclear envelope in micronuclei but is aberrant at ruptured micronuclear envelopes generating damage
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Ectopic Expression Induces Abnormal Somatodendritic Distribution of Tau in the Mouse Brain
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Presynaptic α(2)δ-2 Calcium Channel Subunits Regulate Postsynaptic GABA(A) Receptor Abundance and Axonal Wiring
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Semaphorin4D Induces Inhibitory Synapse Formation by Rapid Stabilization of Presynaptic Boutons via MET Coactivation
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Aberrant accrual of BIN1 near Alzheimer's disease amyloid deposits in transgenic models
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A mutant form of Dmc1 that bypasses the requirement for accessory protein Mei5-Sae3 reveals independent activities of Mei5-Sae3 and Rad51 in Dmc1 filament stability
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PLoS Genet, 2019
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Mitochondrial fusion is required for regulation of mitochondrial DNA replication
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A SEPT1-based scaffold is required for Golgi integrity and function
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Drosophila Ptp4E regulates vesicular packaging for monoamine-neuropeptide co-transmission
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HsSAS-6-dependent cartwheel assembly ensures stabilization of centriole intermediates
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Myosin V regulates synaptopodin clustering and localization in the dendrites of hippocampal neurons
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Phosphorylation of the Bruchpilot N-terminus in Drosophila unlocks axonal transport of active zone building blocks
Driller JH, Lützkendorf J, Depner H, Siebert M, Kuropka B, Weise C, Piao C, Petzoldt AG, Lehmann M, Stelzl U, Zahedi R, Sickmann A, Freund C, Sigrist SJ, Wahl MC.
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Epidermal growth factor (EGF) triggers nuclear calcium signaling through the intranuclear phospholipase Cδ-4 (PLCδ4)
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Mitochondrial fatty acid oxidation and the electron transport chain comprise a multifunctional mitochondrial protein complex
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Neurolastin, a dynamin family GTPase, translocates to mitochondria upon neuronal stress and alters mitochondrial morphology in vivo
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The intramembrane protease SPP impacts morphology of the endoplasmic reticulum by triggering degradation of morphogenic proteins
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