High-speed milling system for TEM, SEM, LM and pharmaceutical milling of pills

Sistema di fresatura per pastiglie farmaceutiche Leica EM RAPID

Il sistema di fresatura Leica EM RAPID per la ricerca farmaceutica consente la preparazione di campioni per l'analisi della distribuzione del principio attivo in farmaci di forma farmaceutica solida.

Mediante una fresa in carburo di tungsteno o in diamante, lo strumento esegue il decapsulamento delle pastiglie senza sbavature e presenta velocità di taglio regolabili comprese tra 300 e 20.000 giri al minuto, rimozione dello step-layer, estrazione silenziosa, filtrazione con un filtro HEPA e supporto singolo o multiplo.

For research use only
Leica EM RAPID
Sistema di fresatura per pastiglie farmaceutiche EM RAPID

Your benefits when working with the EM RAPID specimen trimming device

  • Control the feed for the milling cutter by selecting step sizes of 0.1, 1, 10, or 100 µm
  • Define the milling speed between 300 and 20,000 rpm
  • Easily approach to your sample with the auto-feed function
  • Accurate milling thanks to the perpendicular viewing of the embedded sample block
  • Safe working environment due to the low-noise extraction system with HEPA filter

Prepare exact parallel block-face edges

Easily trim exact parallel block-face edges every time for your TEM and array tomography application with the EM RAPID specimen trimming device. Attain straight ribbon arrays thanks to the raster positions of the specimen arm, which ensure exact 90° corners for any desired block-face size, making downstream sectioning as easy as possible. The EM RAPID is the perfect partner for your EM UC7 or ARTOS 3D ultramicrotome and ensures easy high quality sample sectioning.

  • Exact parallel block-face angles
  • Perfect 90° corners for any desired block-face size
  • Tungsten carbide and diamond milling heads

Excact parallel block-face angles trimmed with the EM RAPID Specimen Trimming Device

Constantly monitor your sample material

With the EM RAPID milling system the unnecessary removal of sample material is eliminated through constant monitoring at all times during sample preparation. The 60 degree swivelling function of the sample holder enables a perpendicular viewing angle to determine the distance to your area of interest on in sample. There is no need to remove the sample which saves time during the trimming procedure whilst keeping your sample material safe. Additionally, benefit from highly precise layer removal thanks to the feed-hand wheel with selectable step-size advance.

  • Constant monitoring of the embedded sample with the 60 ° swivelling function
  • No removal of the sample is required during the trimming process which eliminates the risk of loosing sample material
  • Precise layer removal thank to feed-hand wheel with selectable step-size advance

Constant monitoring with the 60° swivelling function

Mill several pills simultaneously

Increase the efficiency and throughput for pharmaceutical milling applications with the multiple-pill holder of the EM RAPID. It allows glass slide placement directly under the near infrared (NIR) instrument, enabling you to prepare and investigate several tablets simultaneously.

  • Multiple-pill holder
  • Simultaneous decapsulation of single or multiple pill specimens

Multiple-pill holder of the EM RAPID

Safe working environment with optimal illumination

Benefit from a safe particle-free working environment at all time thanks to the low-noise HEPA filter extraction unit and a protective cover which will allow the instrument to operate only when closed. To ensure clear observation of the sample the EM RAPID milling system features a stereo microscope with LED ring illumination to provide constant tracking during the entire milling process.

  • Safe working environment provided by protective cover and low-noise HEPA filter extraction unit
  • Clear observation of the sample thanks to LED ring illumination

Protective cover of the EM RAPID milling system

Choose your workflow according to your biological question

The EM RAPID specimen trimming device will help you get high quality results when conducting biological experiments ranging from standard TEM, SEM and LM applications to pharmaceutical research workflows and many more. For more information on workflow solutions for your research, download our workflow booklets.

Live cell CLEM

This workflow aims to understand ultrastructural changes over time by combining live-cell imaging and instant fixation by high pressure freezing followed by freeze substitution embedding, trimming and ultra-thin sectioning.

Live cell imaging (THUNDER) | High Pressure Freezing (EM ICE) | Freeze Substitution (EM AFS2) | Trimming (EM RAPID) | Ultra-Thin sectioning (UC7) | Staining (EM AC20) | Image analysis in the TEM

Section Tomography 3D Workflow

This workflow enables you to study the organization and interaction of biological structures within three dimensions in a defined volume. First, use high pressure freezing to fix your sample for increased structural preservation and minimisation of artefacts. This step is followed by trimming of the sample for downstream array tomography of ultra-thin serial sections. After staining with the EM AC20, proceed with the image analysis in the SEM.

High Pressure Freezing (EM ICE) | Freeze Substitution (EM AFS2) | Trimming (EM RAPID) | Array tomography ultra-thin sectioning (ARTOS 3D) | Staining (EM AC20) | Image analysis in the TEM

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