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TCS SP8 CARS Microscopio CARS – Imaging "Label Free"

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Full CARS Publication list

Current and basic papers on CARS microscopy on Leica Science Lab

Selected publications using Leica instruments

Chemical fingerprinting of single glandular trichomes of Cannabis sativa by Coherent anti-Stokes Raman scattering (CARS) microscopy,
Paul Ebersbach, Felix Stehle, Oliver Kayser, Erik Freier.
BMC Plant Biology201818:275 doi: doi.org/10.1186/s12870-018-1481-4

Quantitative mapping of triacylglycerol chain length and saturation using broadband CARS microscopy,
A. Paul, Y.J. Wang, C. Brännmark, S. Kumar, M. Bonn, S. H. Parekh.
doi: http://dx.doi.org/10.1101/463000

Cell-Nanoparticle Interactions at Sub(nanometer) Resolution Analysed by Electron Microscopy and Correlative Coherent Anti-Stokes Raman Scattering,
Saarinen J, Gütter F, Lindman M, Agopov M, Fraser-Miller SJ, Scherließ R, Jokitalo E, Santos HA, Peltonen L, Isomäki A, Strachan CJ.
Biotechnol J. 2018 Oct 23. doi: 10.1002/biot.201800413.

Understanding Dissolution and Crystallization with Imaging: A Surface Point of View,
Novakovic D, Isomäki A, Pleunis B, Fraser-Miller SJ, Peltonen L, Laaksonen T, Strachan CJ.
Mol Pharm. 2018 Oct 9. doi: 10.1021/acs.molpharmaceut.8b00840.

Preparation and characterization of multi-component tablets containing co-amorphous salts: Combining multimodal non-linear optical imaging with established analytical methods,
Ojarinta R, Saarinen J, Strachan CJ, Korhonen O, Laitinen R.
Eur J Pharm Biopharm. 2018 Nov;132:112-126. doi: 10.1016/j.ejpb.2018.09.013. Epub 2018 Sep 22.

Chemical imaging of protein hydrogels undergoing alkaline dissolution by CARS microscopy.
Xu B, Chen XD, Mercadé-Prieto R.
Food Chem. 2018 Jun 30;252:16-21. doi: 10.1016/j.foodchem.2018.01.056. Epub 2018 Jan 6.

Label-free identification of myopathological features with coherent anti-Stokes Raman scattering.
Niedieker D, GrosserÜschkamp F, Schreiner A, Barkovits K, Kötting C, Marcus K, Gerwert K, Vorgerd M.
Muscle Nerve. 2018 Apr 16. doi: 10.1002/mus.26140. (Epub ahead of print)

Variability in responses observed in human white adipose tissue models.
Abbott RD, Borowsky FE, Alonzo CA, Zieba A, Georgakoudi I, Kaplan DL.
J Tissue Eng Regen Med. 2018 Mar;12(3):840-847. doi: 10.1002/term.2572. Epub 2017 Nov 10.

Ostreococcus tauri is a high-lipid content green algae that extrudes clustered lipid droplets
Smallwood CR, Chrisler W, Chen JH, Patello E, Thomas M, Boudreau R, Ekman A, Wang H, McDermott G, Evans JE
doi: doi.org/10.1101/249052

Noninvasive Diagnosis of High-Grade Urothelial Carcinoma in Urine by Raman Spectral Imaging.
Yosef HK, Krauß SD, Lechtonen T, Jütte H, Tannapfel A, Käfferlein HU, Brüning T, Roghmann F, Noldus J, Mosig A, El-Mashtoly SF, Gerwert K.
Anal Chem. 2017 Jun 20;89(12):6893-6899. doi: 10.1021/acs.analchem.7b01403. Epub 2017 Jun 5.

Role for formin-like 1-dependent acto-myosin assembly in lipid droplet dynamics and lipid storage.
Pfisterer SG, Gateva G, Horvath P, Pirhonen J, Salo VT, Karhinen L, Varjosalo M, Ryhänen SJ, Lappalainen P, Ikonen E.
Nat Commun. 2017 Mar 31;8:14858. doi: 10.1038/ncomms14858.

Insights into Caco-2 cell culture structure using coherent anti-Stokes Raman scattering (CARS) microscopy.
Saarinen J, Sözeri E, Fraser-Miller SJ, Peltonen L, Santos HA, Isomäki A, Strachan CJ.
Int J Pharm. 2017 May 15;523(1):270-280. doi: 10.1016/j.ijpharm.2017.03.015. Epub 2017 Mar 12.

Noninvasive Diagnosis of High-Grade Urothelial Carcinoma in Urine by Raman Spectral Imaging.
Yosef HK, Krauß SD, Lechtonen T, Jütte H, Tannapfel A, Käfferlein HU, Brüning T, Roghmann F, Noldus J, Mosig A, El-Mashtoly SF, Gerwert K.
Anal Chem. 2017 Jun 20;89(12):6893-6899. doi: 10.1021/acs.analchem.7b01403. Epub 2017 Jun 5.

Virtual staining of colon cancer tissue by label-free Raman micro-spectroscopy.
Petersen D, Mavarani L, Niedieker D, Freier E, Tannapfel A, Kötting C, Gerwert K, El-Mashtoly SF.
Analyst. 2017 Apr 10;142(8):1207-1215. doi: 10.1039/c6an02072k.

Coupling of vinculin to F-actin demands Syndecan-4 proteoglycan.
Cavalheiro RP, Lima MA, Jarrouge-Bouças TR, Viana GM, Lopes CC, Coulson-Thomas VJ, Dreyfuss JL, Yates EA, Tersariol ILS, Nader HB.
Matrix Biol. 2017 Nov;63:23-37. doi: 10.1016/j.matbio.2016.12.006. Epub 2017 Jan 4.

Direct visualization of the arterial wall water permeability barrier using CARS microscopy.
Lucotte BM, Powell C, Knutson JR, Combs CA, Malide D, Yu ZX, Knepper M, Patel KD, Pielach A, Johnson E, Borysova L, Dora KA, Balaban RS.
Proc Natl Acad Sci U S A. 2017 May 2;114(18):4805-4810. doi: 10.1073/pnas.1620008114. Epub 2017 Apr 3.

Lewy pathology in Parkinson's disease consists of a crowded organellar membranous medley
Sarah H. Shahmoradian, Christel Genoud, Alexandra Graff-Meyer, Juergen Hench, Tim Moors, Gabriel Schweighauser, Jing Wang, Kenneth N. Goldie, Rosmarie Suetterlin, Daniel Castano-Diez, Paula Perez-Navarro, Evelien Huisman, Sabine Ipsen, Angela Ingrassia, Yvonne de Gier, Annemieke J.M. Rozemuller, Anne Da Paepe, Johannes Erny, Andreas Staempfli, Joerg Hoernschemeyer, Frederik Grosserueschkamp, Daniel Niedieker, Samir F. El-Mashtoly, Marialuida Quadri, Wilfred F.J. van Ijcken, Vincenzo Bonifati, Klaus Gerwert, Bernd Bohrmann, Stephan Frank, Markus Britschgi, Henning Stahlberg, Wilma van de Berg, Mathias E. Lauer
doi: doi.org/10.1101/137976

Watching dance of the molecules - CARS microscopy.
[Article in Polish; Abstract available in Polish from the publisher]
Korczyński J, Kubiak K, Węgłowska E.
Postepy Biochem. 2017;63(1):44-52.

Label-free in situ imaging of oil body dynamics and chemistry in germination
Gustav Waschatko, Nils Billecke, Sascha Schwendy, Henriette Jaurich, Mischa Bonn, Thomas A. Vilgis, and Sapun H. Parekh
J R Soc Interface. 2016 Oct; 13(123): 20160677. doi: 10.1098/rsif.2016.0677

Label-free visualization of cholesteatoma in the mastoid and tympanic membrane using CARS microscopy
Zou J, Isomäki A, Hirvonen T, Aarnisalo A, Jero J, Pyykkö I
Journal of Otology 2016; 11(3): 127. doi:10.1016/j.joto.2016.09.001

Biochemical and Bioimaging Evidence of Cholesterol in Acquired Cholesteatoma.
Thorsted B, Bloksgaard M, Groza A, Schousboe LP, Færgeman NJ, Sørensen JA, Svane-Knudsen V, Brewer JR.
Ann Otol Rhinol Laryngol. 2016 Aug;125(8):627-33. doi: 10.1177/0003489416642784. Epub 2016 Apr 15.

Lipid droplets as a novel cargo of tunnelling nanotubes in endothelial cells
Ksenia Astanina, Marcus Koch, Christian Jüngst, Andreas Zumbusch, and Alexandra K. Kiemer
Sci Rep. 2015; 5: 11453. Published online 2015 Jun 22. doi: 10.1038/srep11453

Fully automated registration of vibrational microspectroscopic images in histologically stained tissue sections.
Yang C, Niedieker D, Grosserüschkamp F, Horn M, Tannapfel A, Kallenbach-Thieltges A, Gerwert K, Mosig A.
BMC Bioinformatics. 2015 Nov 25;16:396. doi: 10.1186/s12859-015-0804-9.

Colocalization of fluorescence and Raman microscopic images for the identification of subcellular compartments: a validation study.
Krauß SD, Petersen D, Niedieker D, Fricke I, Freier E, El-Mashtoly SF, Gerwert K, Mosig A.
Analyst. 2015 Apr 7;140(7):2360-8. doi: 10.1039/c4an02153c.

Perilipin-related protein regulates lipid metabolism in C. elegans.
Chughtai AA, Kaššák F, Kostrouchová M, Novotný JP, Krause MW, Saudek V, Kostrouch Z, Kostrouchová M
PeerJ. 2015 Sep 1;3:e1213. doi: 10.7717/peerj.1213. eCollection 2015.

Investigation of protein distribution in solid lipid particles and its impact on protein release using coherent anti-Stokes Raman scattering microscopy.
Christophersen PC, Birch D, Saarinen J, Isomäki A, Nielsen HM, Yang M, Strachan CJ, Mu H.
J Control Release. 2015 Jan 10;197:111-20. doi: 10.1016/j.jconrel.2014.10.023. Epub 2014 Nov 3.

Adipose triglyceride lipase is involved in the mobilization of triglyceride and retinoid stores of hepatic stellate cells.
Taschler U, Schreiber R, Chitraju C, Grabner GF, Romauch M, Wolinski H, Haemmerle G, Breinbauer R, Zechner R, Lass A, Zimmermann R.
Biochim Biophys Acta. 2015 Jul;1851(7):937-45. doi: 10.1016/j.bbalip.2015.02.017. Epub 2015 Feb 27.

Seipin is involved in the regulation of phosphatidic acid metabolism at a subdomain of the nuclear envelope in yeast.
Wolinski H, Hofbauer HF, Hellauer K, Cristobal-Sarramian A, Kolb D, Radulovic M, Knittelfelder OL, Rechberger GN, Kohlwein SD.
Biochim Biophys Acta. 2015 Nov;1851(11):1450-64. doi: 10.1016/j.bbalip.2015.08.003. Epub 2015 Aug 12.

Microscopic and spectroscopic techniques to investigate lipid droplet formation and turnover in yeast.
Wolinski H, Kohlwein SD.
Methods Mol Biol. 2015;1270:289-305. doi: 10.1007/978-1-4939-2309-0_21.

Automated identification of subcellular organelles by coherent anti-stokes Raman scattering.
El-Mashtoly SF, Niedieker D, Petersen D, Krauss SD, Freier E, Maghnouj A, Mosig A, Hahn S, Kötting C, Gerwert K.
Biophys J. 2014 May 6;106(9):1910-20. doi: 10.1016/j.bpj.2014.03.025.

Lipid droplet autophagy in the yeast Saccharomyces cerevisiae.
van Zutphen T, Todde V, de Boer R, Kreim M, Hofbauer HF, Wolinski H, Veenhuis M, van der Klei IJ, Kohlwein SD.
Mol Biol Cell. 2014 Jan;25(2):290-301. doi: 10.1091/mbc.E13-08-0448. Epub 2013 Nov 20.

The emergence of lipid droplets in yeast: current status and experimental approaches.
Radulovic M, Knittelfelder O, Cristobal-Sarramian A, Kolb D, Wolinski H, Kohlwein SD.
Curr Genet. 2013 Nov;59(4):231-42. doi: 10.1007/s00294-013-0407-9. Epub 2013 Sep 21.

Remodeling of lipid droplets during lipolysis and growth in adipocytes.
Paar M, Jüngst C, Steiner NA, Magnes C, Sinner F, Kolb D, Lass A, Zimmermann R, Zumbusch A, Kohlwein SD, Wolinski H.
J Biol Chem. 2012 Mar 30;287(14):11164-73. doi: 10.1074/jbc.M111.316794. Epub 2012 Feb 6.

Quantitative imaging of lipid metabolism in yeast: from 4D analysis to high content screens of mutant libraries.
Wolinski H, Bredies K, Kohlwein SD.
Methods Cell Biol. 2012;108:345-65. doi: 10.1016/B978-0-12-386487-1.00016-X.

Quantitative assessment of collagen fibre orientations from two-dimensional images of soft biological tissues.
Schriefl AJ, Reinisch AJ, Sankaran S, Pierce DM, Holzapfel GA.
J R Soc Interface. 2012 Nov 7;9(76):3081-93. Epub 2012 Jul 4.

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