Leica LMD6 & LMD7 Microdissection laser

This curated list features recent scientific publications that have employed Leica’s LMD6 and LMD7 laser microdissection systems in key areas such as cancer research, neuroscience, molecular pathology, forensics, and spatial omics. It is updated regularly to reflect the latest scientific publications utilizing laser microdissection applications.

Explore the full list below to see how Leica LMD systems are enabling scientific success across the globe.

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Single Cell Applications

Laser  Capture  Microdissection:  Methods  and  Protocols: Immunofluorescence  Imaging-Guided  Laser Microdissection  for  Ultralow  Input  Spatial  Tissue Proteomics
Fritzsche S, Coscia F in Roberta  Noberini  (ed.)
Methods  in  Molecular  Biology,  vol.  3015

Separation and identification of two-individual mixed bloodstains using human neutrophil antigen-1 antibodies
Xia X, Zheng JL, Wang SW, Liu Z, Li Z, Wang DY, Li XN, Wu X, Yao J
Int J Legal Med. 2026 Jan 27. doi: 10.1007/s00414-026-03718-z.

Characterisation of the megakaryocyte proteome in patients with Philadelphia negative myeloproliferative neoplasms
Raman I, Bennett C, Pettikiriarachchi A, Ataide R, Zhu Y, Tsui E, Juneja S, Emery-Corbin S, Spall S, Yousef J, Dagley L, Yannakou C, Pasricha SR
Blood 146 (2025) 5539–5540 (Poster)

Spatial Genomics (DNA-Reserach)

Laser  Capture  Microdissection:  Methods  and  Protocols: Laser  Capture  Microdissection  from  Blood  Smears
Matsuo H in Roberta  Noberini  (ed.)
Methods  in  Molecular  Biology,  vol.  3015

Genomic profiling of meiotic errors and early malignant transformation events in ovarian mature teratoma
Takahashi K, Tamura R, Suda K, Yachida N, Yamaguchi M, Mathew RM, Okuda S, Yoshihara K, Nakaoka 
Reproduction, xaaf019, Jan 15th 2026

Laser Microdissection and Near Single-Cell Whole Genome Amplification
Cruz-Flores R, Cáceres-Martínez J, Dhar AK
Methods Mol Biol. 2026;3003:165-173. doi: 10.1007/978-1-0716-5060-8_12.

Spatial Transcriptomics (RNA Research)

Laser  Capture  Microdissection:  Methods  and  Protocols: Laser  Capture  Microdissection  from  Blood  Smears
Matsuo H in Roberta  Noberini  (ed.)
Methods  in  Molecular  Biology,  vol.  3015

Neural crest cell-derived DKK1 and NEDD4 modulate Wnt signalling in the second heart field to orchestrate outflow tract development
Wiszniak S, Alankarage D, Lohraseb I, Marchant C, Secker G, Domingo D, Hartmann J, Zhang T, Parker W, Toubia J, White M, Piltz S, Tondl M, Giannoulatou E, Winlaw D, Blue GM; Congenital Heart Disease Synergy Group; Tam PPL, Thomas P, Harvey N, Dunwoodie SL, Schwarz Q
Nat Commun. 2026 Jan 22. doi: 10.1038/s41467-026-68459-4.

IIIG9 and PP1α form a protein complex in the adherens junctions of polarized ependymal and MDCK cells
Oviedo MJ, Ramírez E, De Lima I, Grondona JM, Cifuentes M, Martínez F, Barahona MJ, Nualart F, Salazar K
Fluids Barriers CNS. 2026 Jan 21;23(1):12. doi: 10.1186/s12987-026-00762-0.

Proteomics, Lipidomics, Metabolomics

Oncogenic Signaling Activation and Potential Biomarkers in Congestive Hepatopathy Revealed by Proteomic Analysis
Morimoto Y, Go K, Suzuki K, Yamamoto H, Fukasawa Y, Ohashi N, Takahashi Y, Kato T
Hepatol Res. 2026 Jan 29. doi: 10.1111/hepr.70133.

Proteomic remodelling of the neurobrillary tangle from “PART” to advanced Alzheimer’s disease
Thierry M, Kavanagh T, Balcomb K, Tang L, Leitner D, Kanshin E, William C, Oakley D, Hyman B, Ueberheide B, Drummond E, Wisniewski T
Research Square, 29th Jan 2026

Clarifying the immunoglobulin light chain variable gene usage in Chinese patients with renal AL amyloidosis
Wang S, Li DY, Liu D, Zhang X, Zhu YY, Wang H, Yu XJ, Zhou FD, Liu G, Yang L, Zhao MH, Wang SX
Amyloid. 2026 Jan 27:1-12. doi: 10.1080/13506129.2026.2619419.

Deep Visual Proteomics (DVP) related

Laser  Capture  Microdissection:  Methods  and  Protocols: Immunofluorescence  Imaging-Guided  Laser Microdissection  for  Ultralow  Input  Spatial  Tissue Proteomics
Fritzsche S, Coscia F in Roberta  Noberini  (ed.)
Methods  in  Molecular  Biology,  vol.  3015

Advances and Applications of Spatial Proteomics: From Organellar Maps to Clinical Translation
Bernardini C, Däther M, Traube FR
Chembiochem. 2026 Jan;27(1):e202500616. doi: 10.1002/cbic.202500616.

High-resolution biology and the evolving nature of skin biopsy analysis in translational dermatology
McGrath JA
British Journal of Dermatology, ljag014, 9th Jan 2026

Fluorescence Applications

Laser  Capture  Microdissection:  Methods  and  Protocols: A  Spatial  Proteomics  Approach  to  Isolate  and  Analyze Amyloid  Proteins  Using  Laser  Capture  Microdissection and  Mass  Spectrometry
Aguilan J, Horton M, Pessin JE, and Sidoli S in Roberta  Noberini  (ed.)
Methods  in  Molecular  Biology,  vol.  3015

Separation and identification of two-individual mixed bloodstains using human neutrophil antigen-1 antibodies
Xia X, Zheng JL, Wang SW, Liu Z, Li Z, Wang DY, Li XN, Wu X, Yao J
Int J Legal Med. 2026 Jan 27. doi: 10.1007/s00414-026-03718-z.

Congophilic fibrillary glomerulonephritis recurrence post-renal transplant: diagnostic challenges and proteomic insights
Watanabe H, Nagamine M, Shintani-Domoto Y, Kawanishi K, Ishino K, Nakamura T, Sumiyoshi S, Konishi E
CEN Case Rep. 2026 Jan 23;15(1):34. doi: 10.1007/s13730-025-01064-4.

Cancer Research

Oncogenic Signaling Activation and Potential Biomarkers in Congestive Hepatopathy Revealed by Proteomic Analysis
Morimoto Y, Go K, Suzuki K, Yamamoto H, Fukasawa Y, Ohashi N, Takahashi Y, Kato T
Hepatol Res. 2026 Jan 29. doi: 10.1111/hepr.70133.

Discovery and development of a new oxazolidinone with reduced toxicity for the treatment of tuberculosis
Crowley BM, Boshoff HI, Boving A, Tan VY, Zhu J, Hoyt F, Miller RR, Ehrhart J, Boyce CW, Young K, Nantermet PG, Su J, Yang L, Painter RE, Corcoran EB, Hoar JL, Oh S, Holtzman DL, Levi M, Anderson A, Otieno MA, Zimmerman M, Kaya F, Massoudi LM, Ramey ME, Bauman AA, Lenaerts AJ, Roberston GT, Dartois V, Wells CD, Barry CE 3rd, Olsen DB
Nat Med. 2026 Jan 13. doi: 10.1038/s41591-025-04164-x.

A multiomic framework for predicting laryngo-esophageal dysfunction following induction chemotherapy in hypopharyngeal-laryngeal carcinoma
Mattavelli D, Compagnoni M, Calza S, Ravanelli M, Plana M, Wichmann G, Paderno A, Zhan Y, Smussi D, Rondi P, Pinacoli A, Medda A, Lorini L, Khelik K, Hovig E, Maffini FA, Kalogerini M, Alberti A, Farina D, Dietz A, Mesia R, Piazza C, Chiocca S, Bossi P; PRESERVE Consortium
ESMO Open. 2025 Dec 29;11(1):105933. doi: 10.1016/j.esmoop.2025.105933.

Neurosciences

Human brain prefrontal cortex proteomics identifies compromised energy metabolism and neuronal function in Schizophrenia
Koopmans F, Dijkstra AA, Li WP, Klaassen RV, Gouwenberg Y, Yao S, Bast L, Verhage M, Karlsson R, Dwork AJ, Stockmeier CA, Hjerling-Leffler J, Sullivan PF, Smit AB
Nat Commun. 2026 Jan 29. doi: 10.1038/s41467-026-68950-y.

Proteomic remodelling of the neurobrillary tangle from “PART” to advanced Alzheimer’s disease
Thierry M, Kavanagh T, Balcomb K, Tang L, Leitner D, Kanshin E, William C, Oakley D, Hyman B, Ueberheide B, Drummond E, Wisniewski T
Research Square, 29th Jan 2026

Neural crest cell-derived DKK1 and NEDD4 modulate Wnt signalling in the second heart field to orchestrate outflow tract development
Wiszniak S, Alankarage D, Lohraseb I, Marchant C, Secker G, Domingo D, Hartmann J, Zhang T, Parker W, Toubia J, White M, Piltz S, Tondl M, Giannoulatou E, Winlaw D, Blue GM; Congenital Heart Disease Synergy Group; Tam PPL, Thomas P, Harvey N, Dunwoodie SL, Schwarz Q
Nat Commun. 2026 Jan 22. doi: 10.1038/s41467-026-68459-4.

Clinical/Pathology/Immunology Research Applications

Extracellular exosome signature links hypertension and Alzheimer's disease
Bastrup JA, Folke J, Kaalund SS, Rasmussen M, Aznar S, Jepps T
Geroscience. 2026 Feb 4. doi: 10.1007/s11357-026-02097-y.

Clarifying the immunoglobulin light chain variable gene usage in Chinese patients with renal AL amyloidosis
Wang S, Li DY, Liu D, Zhang X, Zhu YY, Wang H, Yu XJ, Zhou FD, Liu G, Yang L, Zhao MH, Wang SX
Amyloid. 2026 Jan 27:1-12. doi: 10.1080/13506129.2026.2619419.

Congophilic fibrillary glomerulonephritis recurrence post-renal transplant: diagnostic challenges and proteomic insights
Watanabe H, Nagamine M, Shintani-Domoto Y, Kawanishi K, Ishino K, Nakamura T, Sumiyoshi S, Konishi E
CEN Case Rep. 2026 Jan 23;15(1):34. doi: 10.1007/s13730-025-01064-4.

Developmental Research, Epigenetics & Aging

Comparative insights into molecular pathways influencing germline development in early-divergent angiosperms
Lora J, Tucker MR, Shirley NJ, Ma C, Hormaza JI
Plant J. 2026 Jan;125(2):e70675. doi: 10.1111/tpj.70675.

Genomic profiling of meiotic errors and early malignant transformation events in ovarian mature teratoma
Takahashi K, Tamura R, Suda K, Yachida N, Yamaguchi M, Mathew RM, Okuda S, Yoshihara K, Nakaoka H
Reproduction, xaaf019, Jan 15th 2026

Gene networks associated with early endosperm proliferation and basal endosperm layer differentiation in maize
Zhang S, Ran D, Ryu CH, Li G, Dannenhoffer JM, Wang X, Drews GN, and Yadegari R
bioRxiv, Jan 2nd 2026

Plant Research

Comparative insights into molecular pathways influencing germline development in early-divergent angiosperms
Lora J, Tucker MR, Shirley NJ, Ma C, Hormaza JI
Plant J. 2026 Jan;125(2):e70675. doi: 10.1111/tpj.70675.

Gene networks associated with early endosperm proliferation and basal endosperm layer differentiation in maize
Zhang S, Ran D, Ryu CH, Li G, Dannenhoffer JM, Wang X, Drews GN, and Yadegari R
bioRxiv, Jan 2nd 2026

Single-cell and spatial omics reveal progressive loss of xylem developmental complexity across seed plants
Shuai P, Hsieh JA, Kao CT, Hu CW, Wang R, Kuo SC, Yen MR, Liou PC, Ho YC, Chu CC, Huang S, Liu J, Zhang L, Wu CC, Luo YJ, Li Q, Hsu CC, Huang CL, Su JC, Tseng MC, Chen YL, Mai TL, Lin YJ
Plant Cell. 2025 Oct 19:koaf253. doi: 10.1093/plcell/koaf253.

Forensics

Separation and identification of two-individual mixed bloodstains using human neutrophil antigen-1 antibodies
Xia X, Zheng JL, Wang SW, Liu Z, Li Z, Wang DY, Li XN, Wu X, Yao J
Int J Legal Med. 2026 Jan 27. doi: 10.1007/s00414-026-03718-z.

Invisible WItness: Innovations in the Collection of Touch DNA and the Risk of Forensic Corss Contamination
Irfan M, Haider SA, Yasir M, Akram MA, Adeel M
FORENSIC INSIGHTS AND HEALTH SCIENCES BULLETIN, Volume 3: Issue 2: 2025

Advancements in differentiation between sperm cells and epithelial cells for efficient forensic DNA analysis in sexual assault cases
Dash HR
Int J Legal Med. 2024 Jul 12. doi: 10.1007/s00414-024-03285-1.

Miscellaneous

Structural and chemical compositional characteristics of rubberwood with gelatinous fibre distribution in the tension and opposite wood
Tu X, Li T, Li J, Zhang F, Liu H & Yang L
Wood Sci Technol 60, 28 (2026). 

A Spinster-like Transporter at the Inner Membrane Complex is critical for Toxoplasma gondii cytokinesis, motility and invasion
Sanchez SG, Haase R, Dubois DJ, Héritier M, Humann R, Hulo N, Maco B, Meister I, Scapozza L, Vadas O, Soldati-Favre D
PLoS Pathog. 2026 Jan 28;22(1):e1013886. doi: 10.1371/journal.ppat.1013886.

Similar growth potentials of cyanobacteria and algae explain their coexistence in desert soils
Kyi KM, Levintal E, A Kamennaya N
Sci Rep. 2025 Dec 1;16(1):830. doi: 10.1038/s41598-025-30489-1.

Live Cell Culture

Muscle Structure and Function Recovery: Adalimumab-Calcium Channel Synergy in Post-Ischemic Stroke Sarcopenia
Qi H, Zhang XW, Zhang ZY, Ou SS, Gao YL, Tian D, Jiang YN, Min XR, Zhao AT, Zou JM, Zeng JS, Pu QY, Yang RC, Zeng N
J Cachexia Sarcopenia Muscle. 2025 Dec;16(6):e70097. doi: 10.1002/jcsm.70097.

Ultrasensitive proteomics uncovers nociceptor diversity and novel pain targets
Chakrabarti S, Makhmut A, Mohammadi A, Luo W, Wang L, Lewin GR, Coscia F
bioRxiv, Sept 21, 2025

A 3‑Dimensional Scaffolding System Recapitulates the Hierarchical Osteon Structure
Li X, Sun Y, Wang S, Si C, Li H, and Chang B
ACS Omega 2024, XXXX, XXX, XXX-XXX

Laser microdissection (LMD) is an advanced, highly precise sample preparation technique that enables researchers to isolate pure, defined regions of interest, including single cells, from complex tissue samples. The method ensures reproducibility and accuracy for downstream analyses such as Next Generation Sequencing (NGS) including RNA-seq, and mass spectrometry for spatial genomics, spatial transcriptomics, spatial proteomics & spatial multiomics.

LMD allows non-contact dissection, isolation and gravity-assisted collection of targeted single cells, tissue compartments, cell clusters and even subcellular structures under visual control. These systems uniquely bridge microscopy and molecular biology to unlock true spatial omics insights. Combined with software-guided segmentation, Leica LMD systems enable high throughput workflows for biomarker discovery and identification of therapeutical interaction points. The study by Mund & Coscia et al., describing the Deep Visual Proteomics (DVP) workflow powered by the Leica LMD7 system, was featured on the cover of Nature Biotechnology in August 2022.  Follow-up research by Nordmann et al., published in Nature in 2024, demonstrated how DVP contributed to a life-saving therapy for toxic epidermal necrolysis (TEN), a deadly skin disease. These breakthroughs also contributed to the selection of “spatial proteomics” as Nature’s Method of the Year 2024.