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Scopri nuove applicazioni combinando la microscopia confocale con la microscopia light-sheet.

Microscopio Digital Light Sheet STELLARIS DLS

  • Organoidi e colture cellulari in 3D

    Uno dei più entusiasmanti progressi recenti nella ricerca nel campo delle scienze della vita è lo sviluppo di sistemi di coltura cellulare in 3D, quali gli organoidi, gli sferoidi o i modelli di…
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  • Organismi modello nella ricerca

    Un organismo modello è una specie utilizzata dai ricercatori per studiare specifici processi biologici. Hanno caratteristiche genetiche simili a quelle umane e vengono normalmente impiegate in aree di…
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    Imaging di cellule vive

    Spostando la prospettiva dai singoli componenti per microscopio a una soluzione completa, Leica Microsystems integra microscopio, software per l'imaging LAS X, fotocamere e componenti dedicati di…
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  • Science Lab Topic: Light Sheet Microscopy

    Effects of Clearing Media on Tissue Transparency and Shrinkage

    This study comprehensively evaluates the effects of different clearing media on tissue transparency and shrinkage by comparing freshly dissected dipteran fly brains with their cleared equivalents.…
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  • Science Lab Topic: Light Sheet Microscopy

    Following Ca²⁺ Changes in Acutely Stimulated Spheroids

    Spheroids are easy and cost-effective 3D cell cultures, useful for fundamental and applied research. They can bridge the gap between 2D and in vivo experiments and can be used for high-throughput…
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  • Science Lab Topic: Light Sheet Microscopy

    Analyzing Structural and Functional Testicular Anatomy

    Fleck, Kenzler et al. have shown that, in mice, muscle-like cells are located within the walls of seminiferous tubules. Using CLARITY and a Leica digital light-sheet (DLS) microscope, Fleck, Kenzler…
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  • Science Lab Topic: Light Sheet Microscopy

    Fish and Chips Sheet into the Light

    The zebrafish larval brain is small and contains about 1 million times less neurons than the human counterpart. The neural circuitry and the general bauplan of the vertebrate brain, however, is…
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  • Science Lab Topic: Light Sheet Microscopy

    Understanding Motor Sequence Generation Across Spatiotemporal Scales

    We have developed a microscopy-based pipeline to characterize a developmentally critical behavior at the pupal stage of development, called the ecdysis sequence. We study brain-wide neuronal activity…
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  • Science Lab Topic: Light Sheet Microscopy

    A Quality Metric for the Systematic Evaluation of Clearing Protocols

    3D multicellular spheroids are of interest for studying tumor behavior and evaluating the response of pharmacologically active agents, because they mimic the in vivo tumor environment better than…
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