EM Preparazione del campione

In the webinar entitled "A Multimodal Vitreous Crusade, a Cryo Correlative Workflow from Bench to Beam" a team of experts discusses the exciting world of correlative workflows for structural biology that empower researchers to study fine details of biological structures. Watch and explore the latest developments, instruments, and techniques in cryo workflows for correlative light electron microscopy (cryo-CLEM).

La tomografia crioelettronica (CryoET) viene utilizzata per rilevare le biomolecole all'interno del proprio ambiente cellulare fino a una risoluzione senza precedenti, inferiore a un nanometro.

Block-face created by automatic trimming under fluorescence. Mammalian cells of interest, stained with CellTrackerTM Green are visualized within the block-face using the UC Enuity equipped with the stereo microscope M205 FA. In the background a carbon finder grid in black is visible.

Discover advanced digital ultramicrotomy tools for fast and accurate automated sectioning. Learn about autoalignment, and efficient sample trimming leveraging 3D µCT data. See application examples that advance EM sample preparation workflows. Watch now to enhance your lab's precision and efficiency.

This brochure presents and explains appropriate workflow solutions for the most frequently required sample preparation methods for material science samples.

Automatic alignment of sample and knife on the ultramicrotome UC Enuity, enabling even untrained users to create ultrathin sections with reduced risk of losing precious sections.

Discover the significance of achieving high-quality uniform sections with ultramicrotomy for precise imaging in electron microscopy.

Semiconductor inspection during the production of patterned wafers and ICs (integrated circuits) is important for identifying and minimizing defects. To increase the efficiency of quality control in the early stages of production and to ensure reliable IC chip performance, microscopy solutions should combine different contrast methods that provide complete and accurate information about different defects. Our free guide details microscopy techniques & optimizing quality control. Get your free copy today!

With inverted microscopes, you look at samples from below since their optics are placed under the sample, with upright microscopes you look at samples from above. Traditionally, inverted microscopes are used for life science research, because gravity makes samples sink to the bottom of a holder with aqueous solution and you don’t see a lot from above.

This article shows how electronic IC-chip cross sections can be efficiently and reliably prepared and then analyzed, both visually and chemically at the microscale, with the EM TXP and DM6 M LIBS solutions.

This article describes a method for EBSD sample preparation of challenging materials. The high-quality samples required for electron backscatter diffraction are prepared with broad ion-beam milling.

In this application example we showcase the use of EM-Sample preparation with high pressure freezing, freeze substiturion and ultramicrotomy for marine biology focusing on ultrastructural analysis of dinoflagellates in particular. The mobility the EM ICE unit allowed high pressure freezing directly at the marine station after sample collection.

This workshop covers the sample preparation process for lithium and novel battery sample analysis, as well as other semiconductor samples requiring high-resolution cross-section imaging.

New cryo-light microscopy techniques like LIGHTNING and TauSense fluorescence lifetime-based tools reveal structures for cryo-electron microscopy.

This article describes the major steps of the cryo-electron tomography workflow including super-resolution cryo-confocal microscopy. We describe how subcellular structures can be precisely located in 3D under cryo-fluorescence and how their coordinates are provided for subsequent cryo--FIB milling and cryo-transmission electron microscopy.