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THUNDER Imaging Systems
THUNDER Imaging Systems
このシステムは、サンプルの深部も非侵襲でボケのない鮮明な画像をリアルタイムに提供し、生体の極めて重要な現象に答える助けとなります。カメラベースの蛍光顕微鏡による従来の作業と同様の簡便さで 3D サンプルの鮮明なイメージングを実現します。Computational Clearing 機能を持つ THUNDER システムは、厚みのある立体的なサンプルの高速、高品質イメージングのための新しい装置です。
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THUNDER Imaging Systems
生物学的に重要な 3D モデルを容易に扱えるイメージングシステム：THUNDER システムが登場しました。
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Read our latest articles about THUNDER Imaging Systems
The knowledge portal of Leica Microsystems offers scientific research and teaching material on the subjects of microscopy. The content is designed to support beginners, experienced practitioners and scientists alike in their everyday work and experiments.
Unlocking the Secrets of Organoid Models in Biomedical Research
Get ready to delve deeper into the world of organoids and 3D models, which are essential tools for advancing our understanding of human health. Navigating these complex structures and obtaining clear images for analysis can be challenging. In this event, researchers from The University of Oxford and University College London will join us to show how the THUNDER Imager Cell Spinning Disk can provide more convincing, high-quality data for deeper insights into a variety of models.
Designing the Future with Novel and Scalable Stem Cell Culture
Visionary biotech start-up Uncommon Bio is tackling one of the world’s biggest health challenges: food sustainability. In this webinar, Stem Cell Scientist Samuel East shows how they make stem cell culture media for cellular agriculture safe and economically viable. See how they achieved a 1000x reduction in media costs and developed animal free, food safe iPSC culture media.
神経細胞移動の分子的秘密を解き明かす
発達中の脳における特定部位への神経細胞の移動を調べるには、さまざまなアプローチを用いることができます。このウェビナーでは、オックスフォード大学の専門家が、神経発達過程における大脳皮質の機能層への神経細胞移動の分子メカニズムを解明するために使用している顕微鏡ツールとアッセイについて紹介します。これらのプロセスを理解することは、健全な脳の発達の理解を深め、神経発達障害の治療法を改善する可能性につながります。
How Efficient is your 3D Organoid Imaging and Analysis Workflow?
Organoid models have transformed life science research but optimizing image analysis protocols remains a key challenge. This webinar explores a streamlined workflow for organoid research, starting with real-time 3D cell culture checks. This is followed by high-speed, high-resolution 3D imaging to generate crisp images and cleaner data for accurate AI-based segmentation and quantification of parameters such as growth rate, cell migration and 3D cellular interactions – enabling deeper insights.
How to Get Deeper Insights into your Organoid and Spheroid Models
In this eBook, learn about key considerations for imaging 3D cultures, such as organoids and spheroids, and discover microscopy solutions to shed new insights into dynamic processes in 3D real-time
Imaging Organoid Models to Investigate Brain Health
Imaging human brain organoid models to study the phenotypes of specialized brain cells called microglia, and the potential applications of these organoid models in health and disease.
機械受容性経路とシナプス経路の研究に顕微鏡がいかに役立つか
このポッドキャストでは、Tobi Langenhan教授は、顕微鏡を使ってシナプスのタンパク質集合体を調べるなど、接着型GPCRの機械受容特性の研究を通して、タンパク質のダイナミクスとその空間的相互作用に精通されています。 Abdullah Ahmed,博士との対談では、Tobi博士と彼のグループが答えようとしている主要な質問と、彼らが直面しているいくつかの課題について話します。彼はまた、THUNDER Imagerテクノロジーを使用して無傷のショウジョウバエの幼虫を画像化したときに得た驚きを共有しています。
What are the Challenges in Neuroscience Microscopy?
eBook outlining the visualization of the nervous system using different types of microscopy techniques and methods to address questions in neuroscience.
The Role of Iron Metabolism in Cancer Progression
Iron metabolism plays a role in cancer development and progression, and modulates the immune response. Understanding how iron influences cancer and the immune system can aid the development of new therapeutic approaches.
Going Beyond Deconvolution
Widefield fluorescence microscopy is often used to visualize structures in life science specimens and obtain useful information. With the use of fluorescent proteins or dyes, discrete specimen components are marked in a highly specific manner. To fully understand a structure, visualizing it in 3 dimensions can be necessary, but certain challenges are faced when doing so with microscopy.
Find Relevant Specimen Details from Overviews
Switch from searching image by image to seeing the full overview of samples quickly and identifying the important specimen details instantly with confocal microscopy. Use that knowledge to set up high-resolution image acquisition automatically using templates for slides, dishes, and multi-well plates. Like a GPS for the cells of a specimen, users always have a clear path to high-quality data with the LAS X Navigator software, a powerful navigation tool for the STELLARIS platform. LAS X Navigator enables confocal and fluorescence lifetime experiments to be combined with a stage application and makes all the TauSense tools available for use.
Accurately Analyze Fluorescent Widefield Images
The specificity of fluorescence microscopy allows researchers to accurately observe and analyze biological processes and structures quickly and easily, even when using thick or large samples. However, out-of-focus fluorescence increases background, reduces contrast, and makes accurate image segmentation more challenging. A powerful solution to these issues is the use of THUNDER to remove image blur in combination with Aivia which automates widefield image analysis using AI to improve speed and accuracy. Here, we explore this synergetic approach in more detail.
High-resolution 3D Imaging to Investigate Tissue Ageing
Award-winning researcher Dr. Anjali Kusumbe demonstrates age-related changes in vascular microenvironments through single-cell resolution 3D imaging of young and aged organs.
How to Improve Live Cell Imaging with Coral Life
For live-cell CLEM applications, light microscopy imaging is a critical step for identifying the right cell in the right state at the right time. In this article, Leica experts share their insights on the advantages of working with a widefield system and which obstacles need to be overcome when using sapphire as a cell-culture substrate.
Optimizing THUNDER Platform for High-Content Slide Scanning
With rising demand for full-tissue imaging and the need for FL signal quantitation in diverse biological specimens, the limits on HC imaging technology are tested, while user trainability and ease-of-use at core facilities becomes a matter of cost and efficiency. Here we demonstrate a feasible workflow developed for the THUNDER platform at our facilities, to support diverse research environments with needs ranging from KO-mouse tissue analysis to human cancer.
Physiology Image Gallery
Physiology is about the processes and functions within a living organism. Research in physiology focuses on the activities and functions of an organism’s organs, tissues, or cells, including the physical and chemical phenomena involved. Here we show you images related to physiology using different samples as examples.
従来の蛍光画像THUNDER画像
HeLa 細胞（標識；アクチン_Alexa Fluor 568 ファロイジン、核_YOYO 1 iodide）
THUNDER の技術
THUNDER は、最新の Computational Clearing 法を用いて高解像度、高コントラストの画像を計算処理で提供するデジタルオプティクス技術です。Computational Clearing は、厚いサンプルでしばしば見られるフォーカスアウトしたボケ情報を除去します。これにより、z スタックでも深部の一平面画像でも優れた結果が得られます。
ライカの THUNDER テクノロジーは、ボケのない画像をリアルタイムに取得するため、関連する光学的パラメータをすべて考慮します。
テクノロジーノート
まだ疑問な点がありますか？THUNDERテクノロジーに関するより詳細な解説は、テクノロジーノートをご覧ください。
従来の蛍光画像THUNDER画像
バッタの神経節、従来の蛍光画像（左）、THUNDER 像（右）。厚さ：110µm、データ量：376 MB。Computational Clearing による画像取得時間：3 秒
「大型サンプルでも 2 分以内に驚くほど鮮明な画像を提供する THUNDER はタイムラプス試験に有効です」
