Biowissenschaften

Visionary biotech start-up Uncommon Bio is tackling one of the world’s biggest health challenges: food sustainability. In this webinar, Stem Cell Scientist Samuel East shows how they make stem cell culture media for cellular agriculture safe and economically viable. See how they achieved a 1000x reduction in media costs and developed animal free, food safe iPSC culture media.

Alzheimer's disease, a genetic and sporadic neurodegenerative condition, leads to cognitive decline in mid to late life, marked by β-amyloid plaques and tau tangles. With limited treatment options, new investigative strategies are crucial. The Cell DIVE multiplexed imaging solution allows examination of Alzheimer's brain tissue, potentially uncovering new research avenues. Here, we showcase the Cell DIVE image viewer, enabling users to access the full Alzheimer's multiplexed dataset directly in their browser.

This interview highlights the transformative impact of Mica at Imperial College London. Scientists explain how Mica has been a game-changer, expanding research possibilities and facilitating interdisciplinary collaboration. They explain how detailed live cell imaging with Mica provides more meaningful information, keeping scientists at the forefront of research. The team foresees Mica continuing to open new research avenues, including the study of microfluidics and other advanced applications.

In the webinar entitled "A Multimodal Vitreous Crusade, a Cryo Correlative Workflow from Bench to Beam" a team of experts discusses the exciting world of correlative workflows for structural biology that empower researchers to study fine details of biological structures. Watch and explore the latest developments, instruments, and techniques in cryo workflows for correlative light electron microscopy (cryo-CLEM).

Krebs ist eine komplexe und heterogene Krankheit, die durch Zellen verursacht wird, denen die Wachstumsregulation fehlt. Genetische und epigenetische Veränderungen in einer Zelle oder einer Gruppe von Zellen stören die normale Funktion und führen zu einem autonomen, unkontrollierten Zellwachstum und einer autonomen Proliferation.

Pancreatic cancer, with a mortality rate near 40%, is challenging to treat due to its proximity to major organs. This story explores the complex biology of pancreatic ductal adenocarcinoma (PDAC), examining molecular and spatial determinants of tumor aggression in metabolism, apoptosis, and immunity. Access the full Cell DIVE dataset in your browser to delve deeper into these findings.

Colorectal cancer poses a significant health burden. While surgery is effective initially, some patients develop recurrent secondary disease with poor prognosis, necessitating advanced therapies like immunotherapies. Spatial biology approaches, such as multiplexed imaging with Cell DIVE, can provide crucial insights for developing novel treatments. Access the full Cell DIVE dataset in your browser to explore these findings further through the Minerva image viewer.

This article provides an introduction to the recommendations of 21 CFR Part 11 from the FDA, specifically focusing on the audit trail and user management in the context of cell-culture laboratories. It is intended for professionals in the biotechnology and pharmaceutical industries who are responsible for ensuring agreement with 21 CFR part 11 for electronic records and electronic signatures. A digital microscope approach, e.g. with Mateo FL, offers the advantage of more consistent and efficient electronic documentation of cell-culture results compared to a paper-based method.

Wenn Sie Präparationen durchführen, verbringen Sie oft viele Stunden an den Okularen eines Präpariermikroskops. Bei Leica Microsystems können Sie aus einer Vielzahl von Mikroskopen und einem umfassenden Sortiment an Teilen und Zubehör für die Präparation auswählen, damit Sie das Mikroskopsystem zusammenstellen können, das Ihre Anforderungen optimal erfüllt.

Arbeiten Sie an einem besseren Verständnis neurodegenerativer Erkrankungen oder an einer Untersuchung der Funktionen des Nervensystems? Erfahren Sie, wie Sie mit Bildgebungslösungen von Leica Microsystems Durchbrüche erzielen können.

Spatial mapping of untreated tumors provides an overview of the tumor immune architecture, useful for understanding therapeutic responses. Immunocompetent murine models are essential for identifying immune-dependent events in tumor development and progression. Characterizing these models, with intact immune systems and interacting cellular components, requires a multiplexed approach. We show an AI-powered spatial proteomics approach to study the tumor-immune interactions in murine cancer tissue.

Liegt Ihr Forschungsschwerpunkt auf Virusinfektionen und -krankheiten? Erfahren Sie, wie Sie mit Lösungen für Bildgebung und Probenvorbereitung von Leica Microsystems mehr Erkenntnisse in der Virologie erhalten.

Mit der Kryo-Elektronentomographie (CryoET) lassen sich Biomoleküle in ihrer zellulären Umgebung mit einer noch nie dagewesenen Auflösung von weniger als einem Nanometer auflösen.

Für optimale Ergebnisse während der Bewertung, Sortierung, Manipulation und Bildgebung von Modellorganismen ist es entscheidend feine Details und Strukturen genauestens zu erkennen. Das bildet die Grundlage für richtige Entscheidungen und weitere Forschungsschritte.

Block-face created by automatic trimming under fluorescence. Mammalian cells of interest, stained with CellTrackerTM Green are visualized within the block-face using the UC Enuity equipped with the stereo microscope M205 FA. In the background a carbon finder grid in black is visible.