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Leica Microsystems

Leica Microsystems

Leica Microsystems ist ein weltweit führender Hersteller von Mikroskopen und wissenschaftlichen Instrumenten. Im 19. Jahrhundert als Familienunternehmen gegründet, war die Geschichte des Unternehmens auf dem Weg zum Weltkonzern von beispielloser Innovation geprägt.

Die traditionell enge Zusammenarbeit mit der Wissenschaft ist der Schlüssel zur Innovationstradition von Leica Microsystems, die auf die Ideen der Anwender zurückgreift und auf deren Bedürfnisse zugeschnittene Lösungen schafft. Auf globaler Ebene ist Leica Microsystems in drei Divisionen gegliedert, die alle zu den führenden Anbietern in ihrem jeweiligen Bereich gehören: Life Science, Industrie und Medizin.

Das Unternehmen ist in über 100 Ländern mit 6 Produktionsstandorten in 5 Ländern, Vertriebs- und Serviceorganisationen in 20 Ländern und einem internationalen Händlernetz vertreten. Der Hauptsitz des Unternehmens liegt in Wetzlar, Deutschland.

https://www.leica-microsystems.com/de

Region of a patterned wafer inspected using optical microscopy and automated and reproducible DIC (differential interference contrast). With DIC users are able to visualize small height differences on the wafer surface more easily.

6-Inch Wafer Inspection Microscope for Reliably Observing Small Height Differences

A 6-inch wafer inspection microscope with automated and reproducible DIC (differential interference contrast) imaging, no matter the skill level of users, is described in this article. Manufacturing…
Optical microscope image, which is a composition of both brightfield and fluorescence illumination, showing organic contamination on a wafer surface. The inset images in the upper left corner show the brightfield image (above) and fluorescence image (below with dark background).

Visualizing Photoresist Residue and Organic Contamination on Wafers

As the scale of integrated circuits (ICs) on semiconductors passes below 10 nm, efficient detection of organic contamination, like photoresist residue, and defects during wafer inspection is becoming…
Evolved ARveo 8: Operating Room (OR) set-up.

Augmented Reality: Transforming Neurosurgical Procedures

In this ebook, you will explore the exciting advances that Augmented Reality (AR) brings to the field of neurosurgery. This comprehensive guide, including explanatory videos, addresses key questions…

AI-Powered Multiplexed Image Analysis to Explore Colon Adenocarcinoma

In this application note, we demonstrate a spatial biology workflow via an AI-powered multiplexed image analysis-based exploration of the tumor immune microenvironment in colon adenocarcinoma.

Laser Microdissection Protocols for Tissue and Cell Isolation - Download free eBook

In this Bio-protocol Selections, we present a collection of open-access, detailed methods papers using LCM to purify and isolate tissues and cells from plants, mouse embryos, cancer cells, neurons,…
The role of extracellular signalling mechanisms in the correct development of the human brain

How do Cells Talk to Each Other During Neurodevelopment?

Professor Silvia Capello presents her group’s research on cellular crosstalk in neurodevelopmental disorders, using models such as cerebral organoids and assembloids.
Intestinal organoids label with FUCCI reporter to follow cell cycle dynamics. Courtesy of Franziska Moos. Liberali lab. FMI Basel (Switzerland).

Dual-View LightSheet Microscope for Large Multicellular Systems

Visualizing the dynamics of complex multicellular systems is a fundamental goal in biology. To address the challenges of live imaging over large spatiotemporal scales, Franziska Moos et. al. present…

A Meta-cancer Analysis of the Tumor Spatial Microenvironment

Learn how clustering analysis of Cell DIVE datasets in Aivia can be used to understand tissue-specific and pan-cancer mechanisms of cancer progression
Multiplexed Cell DIVE imaging of Colon Adenocarcinoma (CAC) tissue. A panel of approximately 30 biomarkers targeted towards various leukocyte lineages, epithelial, stromal, and endothelial cell types was utilized to characterize the tumor immune microenvironment in human colon adenocarcinoma (CAC) tissue.

Mapping the Landscape of Colorectal Adenocarcinoma with Imaging and AI

Discover deep insights in colon adenocarcinoma and other immuno-oncology realms through the potent combination of multiplexed imaging of Cell DIVE and Aivia AI-based image analysis
Clustering based analysis reveals various immune cell populations enriched in tumor cells within CT26.WT syngeneic mouse tumor models.

Spatial Architecture of Tumor and Immune Cells in Tumor Tissues

Dig deep into the spatial biology of cancer progression and mouse immune-oncology in this poster, and learn how tumor metabolism can effect immune cell function.
Pancreatic Ductal Adenocarcinoma with 11 Aerobic Glycolysis/Warburg Effect biomarkers shown – BCAT, Glut1, HK2, HTR2B, LDHA, NaKATPase, PCAD, PCK26, PKM2, SMA1, and Vimentin.

IBEX, Cell DIVE, and RNA-Seq: A Multi-omics Approach to Follicular Lymphoma

In a recent study by Radtke et al., a multi-omics spatial biology approach helps shed light on early relapsing lymphoma patients
40x magnification of organoids cluster taken on Mateo TL.Cell type: esophageal squamous carcinoma; scale  bar 15µm. Courtesy of bioGenous, China.

Overcoming Observational Challenges in Organoid 3D Cell Culture

Learn how to overcome challenges in observing organoid growth. Read this article and discover new solutions for real-time monitoring which do not disturb the 3D structure of the organoids over time.
Eine Batterieelektrode, deren Ränder Grate aufweisen (mit roten Pfeilen markiert). Das Bild wurde mit einem Digitalmikroskop DVM6 aufgenommen.

Graterkennung während der Batterieherstellung

Erfahren Sie, wie die optische Mikroskopie zur Graterkennung an Batterieelektroden und zur Bestimmung des Schadenspotenzials eingesetzt werden kann, um eine schnelle und zuverlässige…
Partikel auf der Oberfläche einer Partikelfalle, die für die technische Sauberkeit bei der Batterieproduktion eingesetzt werden kann.

Erkennung von Batteriepartikeln während des Produktionsprozesses

In diesem Artikel wird erläutert, wie die Partikelerkennung und -analyse von Batterien mit optischer Mikroskopie und Laserspektroskopie für eine schnelle, zuverlässige und kostengünstige…
THUNDER image of brain-capillary endothelial-like cells derived from human iPSCs (induced pluripotent stem cells) where cyan indicates nuclei and magenta tight junctions.

Rapid Check of Live Stem Cells in Cell-Culture Inserts set in Multi-Well Plates

See how efficient imaging of live iPSC stem cells within cell-culture inserts set in a multi-well plate can be done to evaluate the cells using a THUNDER Imager. Just read this article.
Camera image during auto alignment. The feedback lines indicate if the correct edges in the image are detected. Green: Vertical center line; Magenta: Upper edge of the light gap; White: Lower edge of the light gap (not visible here, falling together with red line); Red: Knife edge; Blue: Left and right edge of the block face being automatically detected.

Automatic Alignment of Sample and Knife for High Sectioning Quality

Automatic alignment of sample and knife on the ultramicrotome UC Enuity, enabling even untrained users to create ultrathin sections with reduced risk of losing precious sections.
Section ribbons with increasing section thickness - silver to purple ending in blue sections.

High Quality Sectioning in Ultramicrotomy

Discover the significance of achieving high-quality uniform sections with ultramicrotomy for precise imaging in electron microscopy.
Multicolor fixed STED image. Inner ear section, mouse, TauSTED Xtend 589 on AF488 and TauSTED Xtend 775 on AF633-Phalloidin. Sample courtesy of Dennis Derstrof, Klinik für Hals-, Nasen und Ohrenheilkunde, Universität Marburg & Prof. Dr. Dominik Oliver aus dem Institut für Physiologie und Pathophysiologie, Abteilung für Neurophysiologie, Universität Marburg.

Extended Live-cell Imaging at Nanoscale Resolution

Extended live-cell imaging with TauSTED Xtend. Combined spatial and lifetime information allow super-resolution microscopy at extremely low light dose.
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