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THUNDER Imager Model Organism
Imaging di cellule vive
Spostando la prospettiva dai singoli componenti per microscopio a una soluzione completa, Leica Microsystems integra microscopio, software per l'imaging LAS X, fotocamere e componenti dedicati di…
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Microscopia a fluorescenza
La fluorescenza è uno dei fenomeni fisici più comunemente utilizzati nella microscopia biologica e analitica, soprattutto a causa della sua elevata sensibilità e specificità. Scopri come i microscopi…
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Ricerca zebrafish
Per ottenere il miglior risultato nella visualizzazione, separazione, manipolazione e imaging è necessario riuscire a osservare i dettagli e le strutture, così da poter prendere la decisione giusta…
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Neuroscienze
Stai lavorando per una migliore comprensione delle malattie neurodegenerative o stai studiando la funzionalità del sistema nervoso? Scopri in che modo le soluzioni di imaging di Leica Microsystems…
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Organismi modello nella ricerca
Un organismo modello è una specie utilizzata dai ricercatori per studiare specifici processi biologici. Hanno caratteristiche genetiche simili a quelle umane e vengono normalmente impiegate in aree di…
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Virology
L’oggetto della tua ricerca si concentra su infezioni e malattie virali? Scopri in che modo puoi approfondire l’aspetto virologico utilizzando le soluzioni di imaging e la preparazione del campione di…
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Science Lab Topic:
Widefield Microscopy
Download The guide to live cell imaging
In life science research, live cell imaging is an indispensable tool to visualize cells in a state as in vivo as possible. This E-book reviews a wide range of important considerations to take to…
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Science Lab Topic:
THUNDER Imaging
Studying Cell Division
Cell division is a biological process during which all cellular components must be distributed among the daughter cells. The division process requires firm coordination for success. Microscopy is…
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Science Lab Topic:
THUNDER Imaging
Finding new Scaffolds for Tissue Engineering
Tissue engineers use biomaterials for a variety of applications from drug delivery to supporting the regeneration of damaged or lost tissues to creating in vitro disease models. Scaffold architecture…
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Science Lab Topic:
THUNDER Imaging
The Power of Pairing Adaptive Deconvolution with Computational Clearing
Deconvolution is a computational method used to restore the image of the object that is corrupted by the point spread function (PSF) along with sources of noise. In this technical brief, learn how the…
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Science Lab Topic:
THUNDER Imaging
Improvement of Imaging Techniques to Understand Organelle Membrane Cell Dynamics
Understanding cell functions in normal and tumorous tissue is a key factor in advancing research of potential treatment strategies and understanding why some treatments might fail. Single-cell…
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Science Lab Topic:
THUNDER Imaging
Studying Autoimmune Disease
This article discusses how autoimmune diseases, like systemic lupus erythematosus (SLE), can be studied more efficiently using thick, 3D kidney tissue specimens visualized with a THUNDER Imager . SLE…
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Science Lab Topic:
THUNDER Imaging
Image Gallery: THUNDER Imager
To help you answer important scientific questions, THUNDER Imagers eliminate the out-of-focus blur that clouds the view of thick samples when using camera-based fluorescence microscopes. They achieve…
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Science Lab Topic:
THUNDER Imaging
From Organs to Tissues to Cells: Analyzing 3D Specimens with Widefield Microscopy
Obtaining high-quality data and images from thick 3D samples is challenging using traditional widefield microscopy because of the contribution of out-of-focus light. In this webinar, Falco Krüger…
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Science Lab Topic:
THUNDER Imaging
Studying Human Brain Development and Disease
Neural spheroids created from human induced pluripotent stem cells (iPSCs) provide effective and novel tools for studying brain development, as well as the underlying pathological mechanisms of…
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Science Lab Topic:
THUNDER Imaging
An Introduction to Computational Clearing
Many software packages include background subtraction algorithms to enhance the contrast of features in the image by reducing background noise. The most common methods used to remove background noise…
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Science Lab Topic:
THUNDER Imaging
Studying Natural Killer (NK) Cells Derived from Induced Pluripotent Stem Cells (iPSC)
The study of natural killer (NK) cells holds tremendous promise for developing novel immunotherapies. NK cells derived from induced pluripotent stem cells (iPSCs) can be used to create an easily…
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Science Lab Topic:
THUNDER Imaging
Studying Adipose Tissue Development and Expansion
This article discusses sharp, high-contrast imaging of whole mount adipose (fat) tissues specimens, which are thick and round (unsectioned), with a THUNDER Imager using Computational Clearing. Adipose…
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Science Lab Topic:
Basics in Microscopy
Getting Sharper 3D Images of Thick Biological Specimens with Widefield Microscopy
Widefield fluorescence microscopy is often used to visualize structures in life science specimens and obtain useful information. With the use of fluorescent proteins or dyes, discrete specimen…
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Science Lab Topic:
THUNDER Imaging
IL-18 cytokine derived from the enteric nervous system is important for intestinal immunity
Interleukin 18 (IL-18) is a proinflammatory cytokine, which induces cell-mediated immune reaction upon bacterial infection. In the intestine, it is known that IL-18 is produced in immune and…
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Science Lab Topic:
THUNDER Imaging
Cholesterol Homeostasis Modulates Platinum Sensitivity in Human Ovarian Cancer
Ovarian cancer is one of the most severe types of cancers that women can suffer from during their lifetimes. It is the cancer’s tendency for frequent relapses and drug resistance that leads to…
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Science Lab Topic:
THUNDER Imaging
Computational Clearing - Enhance 3D Specimen Imaging
This webinar is designed to clarify crucial specifications that contribute to THUNDER Imagers' transformative visualization of 3D samples and improvements within a researcher's imaging-related…
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Science Lab Topic:
THUNDER Imaging
THUNDER Imagers: High Performance, Versatility and Ease-of-Use for your Everyday Imaging Workflows
This webinar will showcase the versatility and performance of THUNDER Imagers in many different life science applications: from counting nuclei in retina sections and RNA molecules in cancer tissue…
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Science Lab Topic:
THUNDER Imaging
Interview with Magali Mondin on THUNDER Imagers
Magali Mondin, an engineer at the BIC (Bordeaux Imaging Center) in France, describes her experience using a THUNDER Imager in this interview. She had the opportunity to test extensively the THUNDER…
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Science Lab Topic:
THUNDER Imaging
Drosophila Testis Niche Stem Cells – Three Color Computational Clearing
Differentiated living beings such as humans, but also a fruit fly or a plant, possess not only the differentiated cells which form specific tissues, but also those cells whose fate is not yet (or only…
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Science Lab Topic:
THUNDER Imaging
Alzheimer Plaques: fast Visualization in Thick Sections
More than 60% of all diagnosed cases of dementia are attributed to Alzheimer’s disease. Typical of this disease are histological alterations in the brain tissue. So far, there is no cure for this…
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Science Lab Topic:
THUNDER Imaging
THUNDER Technology Note
So far, widefield microscopy was not suitable to image larger volumes, since the contrast of the recorded fluorescence image is reduced by the background (BG) mainly originating from out of focus…
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