From eye to insights, effortlessly

Deep-learning powered segment by example for 2D and 3D images

Aivia 15 empowers scientists with intuitive tools for powerful insights, no AI expertise needed. Simply paint on cells of interest for deep-learning powered detection (modified from Cellpose1), ensuring accurate segmentation adapted for cellular variations. 

Segment by Example lets any scientist harness AI for rapid insights without coding or deep-learning model training.

1. Stringer C, Wang T, Michaelos M, Pachitariu M. Cellpose: a generalist algorithm for cellular segmentation. Nature Methods. 18: 100-106. (2021)

48 channel human colon channel image acquired on Leica Cell DIVE system, analyzed via Aivia Segment by Example and colored by circularity measurements. Image credit:  Melinda Hill, Ph.D. of Leica Microsystems, analyzed in Aivia by Quyen Tran, Ph.D. of Leica Microsystems
48 channel human colon channel image acquired on Leica Cell DIVE system, analyzed via Aivia Segment by Example and colored by circularity measurements. Image credit: Melinda Hill, Ph.D. of Leica Microsystems, analyzed in Aivia by Quyen Tran, Ph.D. of Leica Microsystems

Optimized analysis with Aivia launchpad 

Aivia Launchpad simplifies quantitative analysis with pre-set Guided Sequences and tutorials. 

Aivia presents relevant analysis options based on your desired endpoint and image dimensions.

Customize your analysis with Flexible Chevrons that can be modified, saved, reloaded, and shared.

Aivia Launchpad helps users to get started on the target analysis with a Tutorial Guide and by launching the pre-set Guided Sequence for the analysis workflow.
Aivia Launchpad helps users to get started on the target analysis with a Tutorial Guide and by launching the pre-set Guided Sequence for the analysis workflow.

AI access for all

Aivia makes advanced data analysis accessible for all biologists - with no computer science expertise required.

The Aivia platform has been designed with the end-user in mind. This means with Aivia you can quickly and reliably generate high-quality results. The Aivia platform includes all state-of-the-art applications you will need in a unified user experience.

Quickly train laboratory users on the platform, to conduct their analysis without any specialist expertise.

  • Speed up your imaging projects and publish faster
  • Benefit from next-generation, easy to use machine learning segmentation and classification tools
  • Conduct parameter-free image segmentation
  • Easily train, update and apply deep learning models using local resources or the AiviaCloud platform

Effortless data exploration for deeper insights 

Easily phenotype by gating based on measurements or directly on charts (scatterplot/dimensionality reduction). Use Measurement Selectors to quickly navigate through charts based on different measurements. 

Gain insights from large datasets with our new heatmap binned scatterplot visualization. Share your findings with automated summary reports, including metadata, segmentation settings, phenotyping results, and charts.

Generate rapid insights from different measurements by updating charts with Measurement Selectors. Image credit: pancreatic ductal cancer tissue section by Melinda Hill, Ph.D., Leica Microsystems., analyzed using Aivia by Won Yung Choi, Ph.D. of Leica Microsystems.
Generate rapid insights from different measurements by updating charts with Measurement Selectors. Image credit: pancreatic ductal cancer tissue section by Melinda Hill, Ph.D., Leica Microsystems., analyzed using Aivia by Won Yung Choi, Ph.D. of Leica Microsystems.

3D insights up to 69% faster & easy to use workflow creator 

Accelerate your 3D insights by up to 69%2 with our fastest mesh creation and smoothing for all 3D analysis pipelines. Easily create batch analyses for objects, phenotypes, spatial relations, classification, and channel modification with the Workflow Creator. 

Generate insights about object-based colocalization (partial, full and %-based overlap), and nearest neighbor analysis (nearest, nearest 5, and all in the search range) for any object sets or phenotypes.

  • Get to insights faster with a 69% speedup in 3D analysis pipelines.
  • Export cells based on phenotypes to Leica’s laser dissection microscopes with auto assignment to multiwell plates or collection tubes.
  • Drag-and-drop import of 26 Bioimage.io models into Aivia, with new file format support.

2. Speedup compared to Aivia 14

An example of the heat map of the nearest neighbor between Cluster 3 (cyan cells) to Cluster 12 (rainbow heatmap) with the nearest cells in red, the furthest cells in blue.
An example of the heat map of the nearest neighbor between Cluster 3 (cyan cells) to Cluster 12 (rainbow heatmap) with the nearest cells in red, the furthest cells in blue.

Total freedom on a single platform

Aivia's powerful and fast 2-5D visualization and analysis unlocks all the value of your data - within a single platform.

No longer does your team have to learn to operate and adopt multiple imaging and analyses systems into their workflow - the Aivia platform unifies all state-of-the-art applications you will need in a unified user experience. Aivia can leverage both local and cloud computing resources. You can install and use Aivia both on your local computer as well as via a web browser, AiviaWeb. Aivia works seamlessly with all microscopy imaging systems.

Your team can also access all files created by your imaging systems anywhere - all you need is an internet connection.

  • Powerful and fast 2-5D visualization and analysis - accessible anywhere
  • Includes 22 applications and 20 pre-trained deep learning models (image segmentation, restoration and virtual staining)
  • Reliable and easy to use cloud access with flexible IT architectures supported
  • Over 45 microscopy file formats supported

Start a free trial

Using state-of-the-art, AI-first software architecture, Aivia is a uniquely innovative and complete 2-to-5D image visualization, analysis and interpretation platform designed for the reliable processing and reconstruction of highly complex images in just minutes.

  • Make AI-enhanced image analysis accessible for all - with no computer science expertise required
  • Leverage machine learning capabilities to generate robust and reproducible segmentation results
  • Realize powerful and fast 2-5D visualization and analysis to unleash the value of your data - all within a single platform

Start a free trial

Single timepoint of a time-lapse recording of mammary epithelial micro spheroid cultured in 3D highlighting individual mitotic events. Processed with Aivia. Data courtesy of intelligent imaging group (B. Eismann/C. Conrad at BioQuant/DKFZ Heidelberg)
Single timepoint of a time-lapse recording of mammary epithelial micro spheroid cultured in 3D highlighting individual mitotic events. Processed with Aivia. Data courtesy of intelligent imaging group (B. Eismann/C. Conrad at BioQuant/DKFZ Heidelberg)

Explore Aivia subscription plans

Aivia Subscription Model Plans

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Aivia is available via subscription, giving you the flexibility to select a plan that fits your lab’s needs now, or in the future as your research needs evolve.

With technical support and free software upgrades for the duration of your subscription, you will always have the lasted AI-powered analysis tool for your research.

  • Go - The essential tools to get you started with AI image analysis
  • Elevate - Take your AI image analysis to the next level with CellBio or Neuro
  • Apex - A comprehensive AI image analysis platform for labs and core facilities

1 Aivia Go

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Everything you need to start analyzing images

Aivia Go offers state-of-the-art image visualization and analysis tools in a single platform, including multiple AI-powered features, to meet your challenging image visualization and analysis needs. Simple segmentation workflows and batch processing capabilities yield results faster, helping you leap from data to publication.

Aivia Go supports a large range of applications from 2D to 5D image analysis tasks such as detection and tracking. It is the ideal package for research laboratories and imaging core facilities. No computer expertise required.

  • AI-powered classifiers
  • 12+ image analysis recipes
  • 2D -5D image visualization

Features

Image Analysis Recipes - Deploy a wide range of 2D to 5D image analysis recipes for the most popular analysis applications:

  • Count cells, nuclei and particles in 2D and 3D
  • Track cells (in phase contrast and fluorescence), nuclei, and particles in 2D and 3D
  • Cell proliferation and wound healing assays (phase contrast)
  • Neurite outgrowth
  • Stem cell colony detection (phase contrast) 
  • Cell tracking (phase contrast)

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2 Aivia Elevate

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Take your AI image analysis to the next level with Aivia’s simple workflows

A complete solution for research laboratories and core imaging facilities, Aivia Elevate subscribers can choose specialized AI solutions for either neuro or cell biology image visualization and analysis.

Analyze cellular interactions and measure the distances between different compartments down to the channel level with Elevate for CellBio . It includes tools to perform accurate cell detection in 2D multiplexed images, identify cell phenotypes and explore spatial insights. Or automate challenging neuroimaging tasks, such as neuron tracing, dendrite segmentation, and more with Elevate for Neuro.

Want both options? Upgrade to Aivia Apex for full functionality plus the ability to apply your own deep learning models.

Features 

Cell or Neuron Analysis Recipes - Choose between specialized analysis tools for neuroscience or cell biology research

  • Neuron Analysis Recipes (Fluorescence/EM): Detect and trace neurons in 3D data sets
  • Cell Analysis Recipes (2D/3D): Observe complex cellular interactions in 2D and 3D data sets

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3 Aivia Apex

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A comprehensive AI image analysis platform for labs and core facilities

Aivia Apex is a comprehensive microscopy image analysis solution for researchers who need a variety of image analysis applications. Apex also provides microscopists with the flexibility to apply their own deep learning models, third party models or open-source repositories.   

Ideal for large research groups and core imaging facilities, Aivia Apex’s Floating License Manager allows a site to run all licenses on any machine on their local network.

  • Everything in Elevate Neuro & CellBio
  • Expanded deep learning capabilities
  • Floating license manager

Features

Image Analysis Recipes - Deploy a wide range of 2D to 5D image analysis recipes for the most popular analysis applications

  • Nuclei count and tracking
  • Cell count and tracking
  • Particle count and tracking
  • Cell proliferation assay
  • Neurite outgrowth
  • Wound healing (phase contrast)
  • Stem cell colony detection (phase contrast) 
  • Cell tracking (phase contrast)
  • 3D Object Analysis and Tracking recipes including neuron and cell analysis

Get quote or try Aivia for free

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