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James DeRose , Ph.D.

James DeRose

James DeRose ist wissenschaftlicher und technischer Redakteur für Stereo- und Digitalmikroskopie bei Leica Microsystems. Er verfügt über mehr als 20 Jahre Erfahrung im wissenschaftlichen und technischen Schreiben für Buch- und Zeitschriftenpublikationen. Er ist Mitautor von mehr als 35 wissenschaftlichen und technischen Publikationen, die in internationalen Fachzeitschriften veröffentlicht wurden, von mehr als 45 Präsentationen für internationale wissenschaftliche Konferenzen und Symposien sowie von zwei Patentanmeldungen. Er ist Hauptherausgeber des Buches "Aluminium Alloy Corrosion of Aircraft Structures: Modelling and Simulation", das im Jahr 2012 veröffentlicht wurde. Dieses Buch ist aus dem von der EU im 6. Rahmenprogramm finanzierten Projekt SICOM hervorgegangen. Er hat wissenschaftliche und technische Projekte mit Schwerpunkt auf angewandter F&E und Anwendungsentwicklung in den Bereichen Grenzflächenchemie und -physik, thermische und chemische Verfahrenstechnik, Korrosion und Metallografie, Oberflächenbeschichtungen und -analyse, Materialwissenschaft, Biotechnologie und Zellbiologie geleitet und zu diesen beigetragen. Er verfügt über Erfahrung mit verschiedenen Arten von Mikroskopie- und Analysemethoden. In der Vergangenheit hat er am California Institute of Technology, an der Eidgenössischen Technischen Hochschule in Lausanne sowie bei der Firma Cytion (Molecular Devices) an Projekten der angewandten Forschung und Entwicklung sowie der Anwendungsentwicklung gearbeitet. James promovierte 1993 an der Arizona State University in Physik mit dem Schwerpunkt angewandte Forschung in den Bereichen Oberflächenwissenschaften, physikalische Chemie und Biophysik. Er arbeitet seit August 2013 bei Leica Microsystems.

Images of smooth muscle cells during wound healing. Courtesy L.S. Shankman, Ph.D., University of Virginia.

Studying Wound Healing of Smooth Muscle Cells

This article discusses how wound healing of cultured smooth muscle cells (SMCs) in multiwell plates can be reliably studied over time with less effort using a specially configured Leica inverted…
[Translate to German:] Particles which could be found during cleanliness analysis of parts and components.

Technische Sauberkeit von Automobilkomponenten und -teilen

In diesem Artikel werden die ISO-Norm 16232 und die VDA 19-Richtlinien erläutert und die Verfahren zur Partikelanalyse kurz zusammengefasst. Diese liefern wichtige Kriterien für die Sauberkeit von…
Multiple particles seen on a filter imaged with a microscope

Improving the Cleanliness Analysis Workflow

For automotive manufacturers and automotive component suppliers, obtaining cleanliness results rapidly, accurately, and reliably over the entire workflow is a significant advantage. Often for this…
Two-color caspase assay with tile scan

Multi-Color Caspase 3/7 Assays with Mica

Caspases are involved in apoptosis and can be utilized to determine if cells are undergoing this programmed cell death pathway in so-called caspase assays. These assays can be run by e.g. flow…
Raw widefield and THUNDER image of a mouse dorsal root ganglion with tdTomato (red) expressed in the sensory neurons.

Fast, High-contrast 3D Imaging of Sensory Neurons

This article discusses how fast, high-contrast 3D imaging of dorsal root ganglion (DRG) tissue with a THUNDER Imager Tissue using large volume computational clearing (LVCC) allows sensory neurons to…
Identification of distinct structures_roundworm_Ascaris_female

Find Relevant Specimen Details from Overviews

Switch from searching image by image to seeing the full overview of samples quickly and identifying the important specimen details instantly with confocal microscopy. Use that knowledge to set up…
Documentation of an automotive clutch friction surface with a digital microscope

Verifying Specifications for Auto Parts and Components

During the development and production of automotive parts and components, whether by suppliers or the auto manufacturer, specifications must be met. This goal is important, because the specifications…
Electronic component

Top Challenges for Visual Inspection

This article discusses the challenges encountered when performing visual inspection and rework using a microscope. Using the right type of microscope and optical setup is paramount in order to…
[Translate to German:]  Routine inspection microscope Ivesta 3

How to select the right solution for visual inspection

This article helps users with the decision-making process when selecting a microscope as a solution for routine visual inspection. Important factors that should be considered are described.

Introduction to 21 CFR Part 11 and Related Regulations

This article provides an overview of regulations and guidelines for electronic records (data entry, storage, signatures, and approvals) used in the USA (21 CFR Part 11), EU (GMP Annex 11), and China…

Why is Manual Visual Inspection of Medical Devices so Challenging?

This article discusses how manual visual inspection, which is prevalent in the medical device industry, can lead to inconsistent results. It also addresses the challenges quality managers and…
Dividing fission yeast S. pombe stained with two markers against spindle pole bodies (Pcp1-GFP, green) and cytokinesis ring (Rlc1-mCherry; red).

Studying Cell Division

Cell division is a biological process during which all cellular components must be distributed among the daughter cells. The division process requires firm coordination for success. Microscopy is…

Investigating Synapses in Brain Slices with Enhanced Functional Electron Microscopy

A fundamental question of neuroscience is: what is the relationship between structural and functional properties of synapses? Over the last few decades, electrophysiology has shed light on synaptic…
Topographic analysis of firing pin.

Topographic Analysis of Firing Pin Impressions on Cartridge Cases

The analysis of fired cartridges for primer cup morphology and flattening and firing pin impression (crater) depth using topographic data is discussed in this article. Topographical analysis of the…
Mouse lung sections

Studying Pulmonary Fibrosis

The results shown in this article demonstrate that fibrotic and non-fibrotic regions of collagen present in mouse lung tissue can be distinguished better with polarized light compared to brightfield.…

Keeping Particulate Contamination Under Control in Pharmaceutical Products

This article describes how a 2-methods-in-1 solution combining optical microscopy and laser induced breakdown spectroscopy (LIBS) can be utilized for identification of particulate contaminants in the…

Fast Visual and Chemical Analysis of Contamination and Underlying Layers

Visual and chemical analysis of contamination on materials with a 2-methods-in-1 solution leading to an efficient, more complete analysis workflow is described in this report. A 2-in-1 solution,…

How does an Automated Rating Solution for Steel Inclusions Work?

The rating of non-metallic inclusions (NMIs) to determine steel quality is critical for many industrial applications. For an efficient and cost-effective steel quality evaluation, an automated NMI…
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