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James DeRose , Ph.D.

James DeRose

James DeRose ist Global Marketing Communication Manager bei Leica Microsystems. Sein Schwerpunkt liegt auf der Erstellung optimierter Inhalte für Anwendungen in den Bereichen Life Science, Materialwissenschaften sowie Industrie und Fertigung. Er erstellt Applikationsberichte, Fallstudien, technische Berichte, White Papers, Anwendungsseiten, Produktseiten, Social Media Posts, E-Mails, Testimonials und andere Materialien. Er arbeitet seit 2013 bei Leica Microsystems. In der Vergangenheit arbeitete er an Anwendungsentwicklungsprojekten in den Bereichen Grenzflächenchemie und -physik, Wärme- und Verfahrenstechnik, Korrosion und Metallographie, Oberflächenbeschichtungen, Materialwissenschaften, Biotechnologie und Zellbiologie. Er hat Erfahrung mit verschiedenen Arten von Mikroskopie- und Analysemethoden.

Image of an onion flake taken with a basic Leica compound microscope after it was tested for resistance to fungus and mold growth following part 11 of the ISO 9022 standard.

ISO 9022 Standard Part 11 - Testing Microscopes with Severe Conditions

This article describes a test to determine the robustness of Leica microscopes to mold and fungus growth. The test follows the specifications of the ISO 9022 part 11 standard for optical instruments.
EBSD-Korngrößenverteilung des Querschnitts eines Golddrahtes in einer Siliziummatrix aus dem Inneren einer CPU (Zentraleinheit eines Computers). Die Körner sind mit verschiedenen Farben hervorgehoben.

Hochwertige EBSD-Probenvorbereitung

Es wird eine zuverlässige und effiziente EBSD-Probenvorbereitung von „gemischten“ kristallografischen Materialien mit Ionenbreitstrahlfräsen beschrieben. Das beschriebene Verfahren erzeugt…
[Translate to German:] Stereo microscopes are often considered the workhorses of laboratories and production sites.

Wichtige Faktoren, die Sie bei der Auswahl eines Stereomikroskops berücksichtigen sollten

Stereomikroskope zeichnen sich durch ihre Fähigkeit aus, einen 3D-Eindruck der Probe zu erzeugen. Daher eignen sie sich besonders gut für Inspektion und Nacharbeit, Qualitätskontrolle, Forschung und…
Geringe Vergrößerung DVM6-Bild eines Teils der PCBA-Probe.

Schnelle und zuverlässige Untersuchung von Leiterplatten und Leiterplattenbaugruppen mittels Digitalmikroskopie

Digitalmikroskope bieten Anwendern eine bequeme und schnelle Möglichkeit zur Erfassung hochwertiger, zuverlässiger Bilddaten und zur schnellen Inspektion und Analyse von Leiterplatten (PCBs) und…
Fluorescence microscope image of a life-science specimen

An Introduction to Fluorescence

This article gives an introduction to fluorescence and photoluminescence, which includes phosphorescence, explains the basic theory behind them, and how fluorescence is used for microscopy.
Raw widefield and THUNDER image of calcium transients in Drosophila embryos. Courtesy A. Carreira-Rosario, Clandinin laboratory, California, USA.

Central Nervous System (CNS) Development and Activity in Organisms

This article shows how studying central nervous system (CNS) development in Drosophila-melanogaster embryos expressing a GCaMP calcium indicator in the neurons can be improved with a THUNDER Imager.
Patch pipette touching a murine hippocampal neuron. Image courtesy of A. Aguado, Ruhr University Bochum, Germany.

What is the Patch-Clamp Technique?

This article gives an introduction to the patch-clamp technique and how it is used to study the physiology of ion channels for neuroscience and other life-science fields.
Neurons imaged with DIC contrast.

Differential Interference Contrast (DIC) Microscopy

This article demonstrates how differential interference contrast (DIC) can be actually better than brightfield illumination when using microscopy to image unstained biological specimens.
The Emspira 3 digital microscope offers what users need for comprehensive visual inspection, including comparison, measurement, and documentation sharing.

Digital Inspection Microscope for Industrial Applications

Factors users should consider before choosing a digital inspection microscope for industrial applications, including quality control (QC), failure analysis (FA), and R&D, are described in this…

Going Beyond Deconvolution

Widefield fluorescence microscopy is often used to visualize structures in life science specimens and obtain useful information. With the use of fluorescent proteins or dyes, discrete specimen…
Inspection microscope image of a printed circuit board (PCB) taken with a ring light (RL) and near vertical illumination (NVI).

Microscope Illumination for Industrial Applications

Inspection microscope users can obtain information from this article which helps them choose the optimal microscope illumination or lighting system for inspection of parts or components.

Phasenkontrast und Mikroskopie

Dieser Artikel erklärt den Phasenkontrast, eine optische Mikroskopietechnik, die feine Details von ungefärbten, transparenten Proben sichtbar macht, die mit gewöhnlicher Hellfeldbeleuchtung schwer zu…

Immersion Objectives

How an immersion objective, which has a liquid medium between it and the specimen being observed, helps increase the numerical aperture and microscope resolution is explained in this article.
Phase-contrast image of a MDCK-cell culture and its respective confluency measured by the Mateo TL microscope.

How to Determine Cell Confluency with a Digital Microscope

This article shows how to measure cell confluency in an easy and consistent way with Mateo TL, increasing confidence in downstream experiments.
Intensity distribution (arbitrary color coding) of an image of two points where the distance between them corresponds to the Rayleigh criterion.

Microscope Resolution: Concepts, Factors and Calculation

This article explains in simple terms microscope resolution concepts, like the Airy disc, Abbe diffraction limit, Rayleigh criterion, and full width half max (FWHM). It also discusses the history.
[Translate to German:] Donor (D) and acceptor (A) molecule which participate in FRET (Förster resonance energy transfer).

Was ist FRET mit FLIM (FLIM-FRET)?

Der Beitrag erläutert die FLIM-FRET-Methode, die Resonanzenergietransfer und Fluoreszenz-Lebensdauer-Imaging zur Untersuchung von Protein-Protein Wechselwirkungen kombiniert.

3 Factors Determine the Damage Potential of Particles

This article discusses the 3 factors for determining the potential of a particle to cause damage to parts and components in the automotive and electronic industry. These factors include the…
Raw widefield and THUNDER image of transversal mouse adult fiber lens section. Courtesy N. Houssin, Plagemen lab, Ohio State University, Columbus, USA.

Studying Ocular Birth Defects

This article discusses how lens formation and ocular birth defects can be studied with sharp widefield microscopy images which are acquired rapidly. The mouse ocular lens is used as a model to study…
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