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Multiplexing with Luke Gammon: Advance your Spatial Biology Research

How experts utilize multiplexing in their research with Cell DIVE

Pancreatic Ductal Adenocarcinoma with 11 Apoptosis biomarkers shown – BAK, BAX, BCL2, BCLXL, Caspase9, CIAP1, NaKATPase, PCK26, SMAC, Vimentin, and XIAP. Pancreatic_Ductal_Adenocarcinoma_11_Apoptosis_Markers_ROI5.jpg

Multiplexing imaging is a powerful technique that allows researchers to simultaneously visualize multiple targets in a single sample. This is particularly valuable for studying complex biological systems and can help researchers better understand how different molecules and pathways interact with each other. Access to high-quality multiplexing imaging systems can have a transformative impact on research. By enabling researchers to study complex biological systems in greater detail, these systems can help to uncover new insights into disease processes, identify new drug targets, and ultimately lead to the development of more effective treatments for a wide range of conditions.

Highlights of the Interview

Key Learnings

  • Challenges of multiplexing imaging and how to overcome them
  • How to process large amounts of data created through spatial imaging
  • Role of AI in the future of multiplexed imaging

Multiplexed imaging and how it compares to other imaging techniques

Multiplexed imaging plays a crucial role in cancer research by enabling the comprehensive characterization of tumor microenvironments. Multiplexed imaging allows researchers to simultaneously visualize various cell types and their interactions within the tumor, providing valuable insights into the tumor ecosystem. This information can help in understanding the tumor's response to therapy, predicting treatment outcomes, and identifying potential targets for immunotherapy. Additionally, multiplexed imaging facilitates the analysis of biomarker expression patterns in cancer samples. By examining multiple biomarkers simultaneously, researchers can assess the expression levels and spatial distribution of different molecules involved in cancer progression. This aids in identifying specific molecular signatures associated with different tumor subtypes, patient stratification, and predicting therapeutic response. The comprehensive analysis provided by multiplexed imaging empowers researchers to unravel the intricate complexities of cancer biology, paving the way for personalized medicine approaches and the development of targeted therapies.

In this interview, Dr. Luke Gammon, Screening Corp Facility Manager at Queen Mary University London, and Dr. David Pointu, Advanced Workflow Specialist at Leica Microsystems, discuss multiplexing imaging and how it compares to other imaging techniques. They cover the main goals of the facility, the importance of multiplexing in accessing and reusing precious samples, and the benefits it provides over traditional imaging methods. Dr. Pointu also provides insights into how multiplexing using Leica Microsystems' Cell DIVE helps produce clear tissue images at scale, using 60+ biomarkers. They also discuss their pain points, and the future potential of multiplexing.

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