Neuroscience Image Gallery

Exploring structure and function of nervous system at a cellular level with Leica Microsystems instruments

Virally labeled neurons (red) and astrocytes (green) in a cortical spheroid derived from human induced pluripotent stem cells. THUNDER Model Organism Imagerwith a 2x 0.15 NA objective at 3.4x zoomwas used to produce this 425 μm Z-stack (26 positions), which is presented here as an Extended Depth of Field(EDoF)projection.  THUNDER_Imager_Model-Org_Header-Gallery-Neuroscience.jpg

Neuroscience commonly uses microscopy to study the nervous system’s function and understand neurodegenerative diseases.

Neuroscience Images taken with THUNDER Imagers

See how THUNDER Imagers can help imaging cortical region of the human brain, Alzheimer’s plaques and D2 dopamine expression in mouse brain, neural spheroids and crest cells, cranial nerve development, axon regeneration, brain function after injury, disease, or aging.

Mouse brain cortex

Virally labeled neuron

Mouse brain

Dr Ashok K. Shetty labat Texas A&M University (TAMU) is interested in developing clinically applicable strategies that are efficacious for enhancing brain function after injury, disease, or aging. One of the central areas is developing clinically feasible strategies for improving hippocampal neurogenesis and memory and mood function in aging and Alzheimer’s disease models via stimulation of endogenous neural stem/progenitor cells in neurogenic regions of the brain using drugs and biologics. Lab member Dr Maheedhar Kodali’s latest project is to check expression of AMPK in Microglia (IBA-1+) to know the effects of their investigating compound in aging.

Microglia in hippocampal region

Cortical neurons

Mouse Brain 1 mm Blood Vessels and nuclei CUBIC

Mouse embryonic kidney

Mouse cortical neuron

Adult rat brain

Uncleared human brain organoid

Neuroscience Images taken with STELLARIS confocal platform

Neuroscience studies require a variety of confocal imaging techniques to allow the study of the nervous system. For example, Multiphoton and light sheet techniques allow the study of large and deep tissues,  such as brain sections; STED super-resolution is key to address neuronal spines structure, synaptic plasticity, and protein interactions at the synapse level. Fluorescence lifetime imaging can report on microenvironment changes in calcium and pH.

Multicolor Deep In Vivo Imaging to uncover the interplay of various players in neurodegenerative diseases

Neurodegenerative diseases are usually caused by a combination of different factors. Being able to visualize multiple players at once greatly helps to investigate and understand how different compoonents interact and influence each other. To do this, a microscope that combines deep tissue penetration with spectral flexibility to enable multicolor imaging liek STELLARIS 8 DIVE is the best choice.

Multicolor Deep In Vivo Imaging to uncover the interplay of various players in neurodegenerative diseases

Neurodegenerative diseases are usually caused by a combination of different factors. Being able to visualize multiple players at once greatly helps to investigate and understand how different compoonents interact and influence each other. To do this, microscope that combines deep tissue penetration with spectral flexibility to enable multicolor imaging like STELLARIS 8 DIVE is the best choice.

Tile scan overview of an unstained paraffin section of an adult Drosophila brain

STELLARIS confocal platform

Detail view from a tile scan of an unstained paraffin section of an adult Drosophila brain

STELLARIS confocal platform

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