Visualizing Protein Degradation and Aggregation in the Living Cell

Webinar on-demand

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Our guest speaker, Prof. Dr. Eric Reits, presents his work on neurodegenerative disorders. Reits’ group are experts on the subject of Huntington’s disease and work towards identifying leads for potential therapies. Presenting data obtained from a range of microscopy techniques, using a variety of different labels and probes, Eric shares his findings on protein aggregates and the co-localization of components of the ubiquitin-proteasome system (UPS) in these aggregates. If you haven’t seen Eric present before, you are in for a treat. Eric is also an excellent cartoonist, using his fun sketches to full effect in his presentations.

Key Learnings

  • both proteasomes and ubiquitin are reversibly recruited to aggregates, with ongoing (de)ubiquitination of proteins in aggregates, and that proteasomes are able to degrade these proteins
  • different microscopy approaches, including live cell imaging and confocal FRAP and FLIM, are used in this valuable research into neurodegenerative disorders such as Alzheimer’s, Parkinson’s and Huntington’s disease 
  • the use of different fluorescent labels, activity-based probes and quenched substrates uncovered key information

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