Prof. Dr. Eric Reits is Professor of Cellular Imaging and Research Group Leader at AMC-UvA, Amsterdam. He also holds the post of Head of the Microscopy and Flow Core Facility at the AMC. He is part of the Van Leeuwenhoek Centre for Advanced Microscopy (LCAM) alongside Prof Dr Kees Jalink (NKI) and Prof Dr Dorus Gadella (FNWI-UvA), Chair of the NL-BioImaging, Secretary of the Dutch Microscopy Society and the co-founder of the Dutch Huntington's Disease foundation.
- both proteasomes and ubiquitin are reversibly recruited to aggregates, with ongoing (de)ubiquitination of proteins in aggregates, and that proteasomes are able to degrade these proteins
- different microscopy approaches, including live cell imaging and confocal FRAP and FLIM, are used in this valuable research into neurodegenerative disorders such as Alzheimer’s, Parkinson’s and Huntington’s disease
- the use of different fluorescent labels, activity-based probes and quenched substrates uncovered key information
This article shows how diseases related to scaffold proteins and protein signaling can be studied in…Jan 23, 2023Read article