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LightSheet microscope Leica TCS SP8 DLS

  • 3D Biology

    Improve Your 3D Cell Biology Workflow with Digital LightSheet Microscopy.The investigation of cellular spheroids with the Leica SP8 Digital LightSheet (DLS) microscope reveals meaningful results of…
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  • Science Lab Topic: Light Sheet Microscopy

    Using Mounting Frames for DLS Sample Preparation

    Sample handling is an important topic in the context of Light Sheet Microscopy. The TCS SP8 DLS integrates Light Sheet technology into an inverted confocal platform and can hence make use of general…
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  • Science Lab Topic: Light Sheet Microscopy

    Using a Rotation Device for DLS Sample Mounting

    The TCS SP8 DLS from Leica Microsystems is an innovative concept to integrate the Light Sheet Microscopy technology into the confocal microscope. Due to its unique optical architecture samples can be…
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  • Science Lab Topic: Light Sheet Microscopy

    DLS Sample Preparation: Using U-Shaped Glass Capillaries for Sample Mounting

    The TCS SP8 DLS microscope system from Leica Microsystems is an innovative concept which integrates the Light Sheet Microscopy technology into the SP8 confocal platform. Due to its unique optical…
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  • Science Lab Topic: Confocal Microscopy

    Clarifying Tissue Clearing

    Biological specimens are intrinsically three dimensional; however because of the obscuring effects of light scatter, imaging deep into a tissue volume is problematic. Although efforts to eliminate the…
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  • Science Lab Topic: Multiphoton Microscopy

    Clearing of Fixed Tissue: A Review from a Microscopist’s Perspective

    Chemical clearing of fixed tissues is becoming a key instrument for the three-dimensional reconstruction of macroscopic tissue portions, including entire organs. Indeed, the growing interest in this…
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  • Science Lab Topic: Super-Resolution

    Super-Resolution Mapping of Neuronal Circuitry With an Index-Optimized Clearing Agent

    Super-resolution imaging deep inside tissues has been challenging, as it is extremely sensitive to light scattering and spherical aberrations. Here, we report an optimized optical clearing agent for…
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  • Science Lab Topic: Light Sheet Microscopy

    Light Sheet Microscopy Turned Vertically

    Living cells and organisms often suffer from the high light intensities used for fluorescent imaging. Light sheet microscopy reduces phototoxic effects and bleaching by illuminating a specimen in only…
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  • Science Lab Topic: Light Sheet Microscopy

    "The Leica Digital Light Sheet Module – a Clever Example of Thinking Out of the Box"

    Bram van den Broek is a postdoctoral fellow at the Netherlands cancer institute in Amsterdam where he supports the advanced microscopy techniques in the laboratory of Kees Jalink. Working with Leica…
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  • Science Lab Topic: Light Sheet Microscopy

    Confocal and Digital Light Sheet Imaging

    Optical imaging instrumentation can magnify tiny objects, zoom in on distant stars and reveal details that are invisible to the naked eye. But it notoriously suffers from an annoying problem: the…
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  • Science Lab Topic: Light Sheet Microscopy

    Light Sheet Fluorescence Microscopy: Beyond the Flatlands

    Light Sheet Fluorescence Microscopy (LISH-M) is a true fluorescence optical sectioning technique, first described by Heinrich Siedentopf in 1902 under the name of Ultramicroscopy. Light sheet…
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  • Science Lab Topic: Light Sheet Microscopy

    Quantitative Imaging in Cell Biology: Light Sheet Microscopy

    This chapter introduces the concept of light sheet microscopy along with practical advice on how to design and build such an instrument. Selective plane illumination microscopy is presented as an…
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  • Science Lab Topic: Light Sheet Microscopy

    Light Sheet Fluorescence Microscopy - A Review

    Light sheet fluorescence microscopy (LSFM) functions as a non-destructive microtome and microscope that uses a plane of light to optically section and view tissues with subcellular resolution. This…
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  • Science Lab Topic: Light Sheet Microscopy

    Selective Plane Illumination Microscopy Techniques in Developmental Biology

    Selective plane illumination microscopy (SPIM) and other fluorescence microscopy techniques in which a focused sheet of light serves to illuminate the sample have become increasingly popular in…
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