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Leica TCS SP8 MP Multiphoton Microscope

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  • Agbani, E. O., Cash, J., Williams, C. & Poole, A. Phosphatidylserine Exposure after Vascular Injury-Platelet or Endothelial. bioRxiv, (2017).
  • Brunt, L. H., Begg, K., Kague, E., Cross, S. & Hammond, C. L. Wnt Signalling Controls the Response to Mechanical Loading during Zebrafish Joint Development. bioRxiv, (2017).
  • Frétaud, M. et al. High-resolution 3D imaging of whole organ after clearing: taking a new look at the zebrafish testis. Scientific Reports 7, 43012, (2017).
  • Joe, A. et al. Antibacterial mechanism of ZnO nanoparticles under dark conditions. Journal of Industrial and Engineering Chemistry 45, 430-439, (2017).
  • Kwon, N. et al. An efficient two-photon fluorescent probe for human NAD(P)H:quinone oxidoreductase (hNQO1) detection and imaging in tumor cells. Chemical Communications 53, 525-528, (2017).
  • Mayrhofer, M. et al. A novel brain tumour model in zebrafish reveals the role of YAP activation in MAPK- and PI3K-induced malignant growth. Dis. Model. Mech. 10, 15-28, (2017).
  • Nakamachi, E., Noma, T., Nakahara, K., Tomita, Y. & Morita, Y. Multiphoton microscope measurement–based biphasic multiscale analyses of knee joint articular cartilage and chondrocyte by using visco-anisotropic hyperelastic finite element method and smoothed particle hydrodynamics method. International Journal for Numerical Methods in Biomedical Engineering, e2864-n/a, (2017).
  • Qin, Z., Balimunkwe, R. M. & Quan, T. Age-related reduction of dermal fibroblast size up-regulates multiple matrix metalloproteinases as observed in aged human skin in vivo. British Journal of Dermatology, n/a-n/a, (2017).
  • Thompson, C., Rahim, S., Arnold, J. & Hielscher, A. Loss of caveolin-1 alters extracellular matrix protein expression and ductal architecture in murine mammary glands. PloS one 12, e0172067, (2017).
  • Wargachuk, R. et al. VCP/p97 regulates β2AR quality control during receptor biosynthesis. Cellular Signalling 30, 50-58, (2017).
  • Zanello, M. et al. Multimodal optical analysis discriminates freshly extracted human sample of gliomas, metastases and meningiomas from their appropriate controls. Scientific Reports 7, 41724, (2017).
  • Zhang, Y.-P. et al. A new pyrazoline-based probe of quenched fluorescent reversible recognition for Cu2 + and its application in cells. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 177, 147-152, (2017).


2003 - 2015

  • Albeiroti, S., Ayasoufi, K., Hill, D. R., Shen, B. & de la Motte, C. A. Platelet hyaluronidase-2: an enzyme that translocates to the surface upon activation to function in extracellular matrix degradation. Blood 125, 1460-1469, (2015).
  • Arden, J. D. et al. Small-molecule agonists of mammalian Diaphanous-related (mDia) formins reveal an effective glioblastoma anti-invasion strategy. Molecular biology of the cell 26, 3704-3718, (2015).
  • Baruzzi, A. et al. Sos1 Regulates Macrophage Podosome Assembly and Macrophage Invasive Capacity. Journal of immunology (Baltimore, Md. : 1950) 195, 4900-4912, (2015).
  • Bender, S. B. et al. Regional variation in arterial stiffening and dysfunction in Western diet-induced obesity. Am J Physiol Heart Circ Physiol 309, H574-582, (2015).
  • Chakraborty, S. et al. Lipopolysaccharide modulates neutrophil recruitment and macrophage polarization on lymphatic vessels and impairs lymphatic function in rat mesentery. Am J Physiol Heart Circ Physiol 309, H2042-2057, (2015).
  • Clouthier, D. L. et al. Requisite role for Nck adaptors in cardiovascular development, endothelial-to-mesenchymal transition, and directed cell migration. Mol Cell Biol 35, 1573-1587, (2015).
  • Facchin, L., Duboue, E. R. & Halpern, M. E. Disruption of Epithalamic Left-Right Asymmetry Increases Anxiety in Zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience 35, 15847-15859, (2015).
  • Gerhold, K. J., Drdla-Schutting, R., Honsek, S. D., Forsthuber, L. & Sandkuhler, J. Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude. The Journal of neuroscience : the official journal of the Society for Neuroscience 35, 9580-9594, (2015).
  • Gonzalez-Prieto, R., Cuijpers, S. A., Luijsterburg, M. S., van Attikum, H. & Vertegaal, A. C. SUMOylation and PARylation cooperate to recruit and stabilize SLX4 at DNA damage sites. EMBO Rep 16, 512-519, (2015).
  • Hasenberg, A. et al. Catchup: a mouse model for imaging-based tracking and modulation of neutrophil granulocytes. Nat Methods 12, 445-452, (2015).
  • Hinton, T. J. et al. Three-dimensional printing of complex biological structures by freeform reversible embedding of suspended hydrogels. Sci Adv 1, e1500758, (2015).
  • Jessen, S. B. et al. GABAA Receptor-Mediated Bidirectional Control of Synaptic Activity, Intracellular Ca2+, Cerebral Blood Flow, and Oxygen Consumption in Mouse Somatosensory Cortex In Vivo. Cereb Cortex 25, 2594-2609, (2015).
  • Jessen, S. B., Mathiesen, C., Lind, B. L. & Lauritzen, M. Interneuron Deficit Associates Attenuated Network Synchronization to Mismatch of Energy Supply and Demand in Aging Mouse Brains. Cereb Cortex, bhv261, (2015).
  • Liang, H. et al. Distribution of raphespinal fibers in the mouse spinal cord. Mol Pain 11, 42, (2015).
  • Myklebust, L. M. et al. Biochemical and cellular analysis of Ogden syndrome reveals downstream Nt-acetylation defects. Hum Mol Genet 24, 1956-1976, (2015).
  • Rochon, E. R., Wright, D. S., Schubert, M. M. & Roman, B. L. Context-specific interactions between Notch and ALK1 cannot explain ALK1-associated arteriovenous malformations. Cardiovasc Res 107, 143-152, (2015).
  • Selvaratnam, J., Paul, C. & Robaire, B. Male Rat Germ Cells Display Age-Dependent and Cell-Specific Susceptibility in Response to Oxidative Stress Challenges. Biology of reproduction 93, 72, (2015).
  • Sim, J. Y. et al. Spatial distribution of cell-cell and cell-ECM adhesions regulates force balance while main-taining E-cadherin molecular tension in cell pairs. Molecular biology of the cell 26, 2456-2465, (2015).
  • Sodhi, K. et al. pNaKtide inhibits Na/K-ATPase reactive oxygen species amplification and attenuates adipogenesis. Sci Adv 1, e1500781, (2015).
  • Ueta, M. et al. Intravital imaging of the cellular dynamics of LysM-positive cells in a murine corneal suture model. Br J Ophthalmol, bjophthalmol-2015-307024, (2015).
  • Xue, C. et al. CRISPR interference and priming varies with individual spacer sequences. Nucleic Acids Res 43, 10831-10847, (2015).
  • Zhao, S. et al. Three-dimensional graphene/Pt nanoparticle composites as freestanding anode for enhancing performance of microbial fuel cells. Sci Adv 1, e1500372, (2015).
  • Apellaniz, B. et al. Cholesterol-dependent membrane fusion induced by the gp41 membrane-proximal external region-transmembrane domain connection suggests a mechanism for broad HIV-1 neutralization. Journal of virology 88, 13367-13377, (2014).
  • Burford, J. L. et al. Intravital imaging of podocyte calcium in glomerular injury and disease. J Clin Invest 124, 2050-2058, (2014).
  • Conway, J. R., Carragher, N. O. & Timpson, P. Developments in preclinical cancer imaging: innovating the discovery of therapeutics. Nat Rev Cancer 14, 314-328, (2014).
  • Fletcher, R. et al. The role of the niemann-pick disease, type c1 protein in adipocyte insulin action. PLoS One 9, e95598, (2014).
  • Gehlsen, U. et al. Non-Invasive Multi-Dimensional Two-Photon Microscopy enables optical fingerprinting (TPOF) of immune cells. J Biophotonics 9999, n/a-n/a, (2014).
  • Gyoneva, S. et al. Adenosine A2A receptor antagonism reverses inflammation-induced impairment of microglial process extension in a model of Parkinson's disease. Neurobiol Dis 67, 191-202, (2014).
  • Ihermann-Hella, A. et al. Mitogen-activated protein kinase (MAPK) pathway regulates branching by remodeling epithelial cell adhesion. PLoS Genet 10, e1004193, (2014).
  • Kodiha, M. et al. Gold nanoparticles induce nuclear damage in breast cancer cells, which is further amplified by hyperthermia. Cellular and molecular life sciences : CMLS 71, 4259-4273, (2014).
  • Landemaine, A., Rescan, P. Y. & Gabillard, J. C. Myomaker mediates fusion of fast myocytes in zebrafish embryos. Biochem Biophys Res Commun 451, 480-484, (2014).
  • Liu, Y. L. et al. Protective effects of Gingko biloba extract 761 on myocardial infarction via improving the viability of implanted mesenchymal stem cells in the rat heart. Mol Med Rep 9, 1112-1120, (2014).
  • Malathi, K. et al. RNase L interacts with Filamin A to regulate actin dynamics and barrier function for viral entry. MBio 5, e02012, (2014).
  • McDade, J. R., Archambeau, A. & Michele, D. E. Rapid actin-cytoskeleton-dependent recruitment of plasma membrane-derived dysferlin at wounds is critical for muscle membrane repair. FASEB J 28, 3660-3670, (2014).
  • Morgado-Palacin, L. et al. Non-genotoxic activation of p53 through the RPL11-dependent ribosomal stress pathway. Carcinogenesis, bgu220, (2014).
  • Palczewska, G. et al. Noninvasive two-photon microscopy imaging of mouse retina and retinal pigment epithelium through the pupil of the eye. Nature medicine 20, 785-789, (2014).
  • Ritsma, L. et al. Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging. Nature 507, 362-365, (2014).
  • Serrat, M. A., Efaw, M. L. & Williams, R. M. Hindlimb heating increases vascular access of large molecules to murine tibial growth plates measured by in vivo multiphoton imaging. Journal of applied physiology 116, 425-438, (2014).
  • Wasik, A. A. et al. Ezrin is down-regulated in diabetic kidney glomeruli and regulates actin reorganization and glucose uptake via GLUT1 in cultured podocytes. Am J Pathol 184, 1727-1739, (2014).
  • Wen, X. et al. Brain-targeted delivery of trans-activating transcriptor-conjugated magnetic PLGA/lipid nanoparticles. PLoS One 9, e106652, (2014).
  • Yamamoto, H. et al. Abstract 4460: Super carbonate apatite as simplified systemic nanoparticle carrier for therapy of solid tumors. Cancer Res. 74, 4460-, (2014).
  • Zhao, X., Stafford, B. K., Godin, A. L., King, W. M. & Wong, K. Y. Photoresponse diversity among the five types of intrinsically photosensitive retinal ganglion cells. The Journal of physiology 592, 1619-1636, (2014).
  • Chow, Z., Mueller, S. N., Deane, J. A. & Hickey, M. J. Dermal regulatory T cells display distinct migratory behavior that is modulated during adaptive and innate inflammation. Journal of immunology (Baltimore, Md. : 1950) 191, 3049-3056, (2013).
  • Fu, Y. et al. Two-photon ratiometric fluorescent sensor based on specific biomolecular recognition for selective and sensitive detection of copper ions in live cells. Anal Chem 85, 11936-11943, (2013).
  • Gonzalez, J. M., Jr., Hamm-Alvarez, S. & Tan, J. C. Analyzing live cellularity in the human trabecular meshwork. Investigative ophthalmology & visual science 54, 1039-1047, (2013).
  • Gregg, B. et al. Replication and distribution of Toxoplasma gondii in the small intestine after oral infection with tissue cysts. Infection and immunity 81, 1635-1643, (2013).
  • Hackl, M. J. et al. Tracking the fate of glomerular epithelial cells in vivo using serial multiphoton imaging in new mouse models with fluorescent lineage tags. Nature medicine 19, 1661-1666, (2013).
  • Huang, A. S., Gonzalez, J. M., Jr., Le, P. V., Heur, M. & Tan, J. C. Sources of structural autofluorescence in the human trabecular meshwork. Investigative ophthalmology & visual science 54, 4813-4820, (2013).
  • Rademakers, T. et al. Plaque-associated vasa vasorum in aged apolipoprotein E-deficient mice exhibit proatherogenic functional features in vivo. Arterioscler Thromb Vasc Biol 33, 249-256, (2013).
  • Westein, E. et al. Atherosclerotic geometries exacerbate pathological thrombus formation poststenosis in a von Willebrand factor-dependent manner. Proceedings of the National Academy of Sciences of the United States of America 110, 1357-1362, (2013).
  • Yuen, M. Y. et al. Characterization of Ca(2+) signaling in the external yolk syncytial layer during the late blastula and early gastrula periods of zebrafish development. Biochimica et biophysica acta 1833, 1641-1656, (2013).
  • Huang, A. S., Le, P., Gonzalez, J. M., Jr. & Tan, J. In situ Visualization of Extracellular Matrix Biomarkers in Human Trabecular Meshwork. Invest. Ophthalmol. Vis. Sci. 53, 3257-, (2012).
  • Malide, D., Metais, J. Y. & Dunbar, C. E. Dynamic clonal analysis of murine hematopoietic stem and progenitor cells marked by 5 fluorescent proteins using confocal and multiphoton microscopy. Blood 120, e105-116, (2012).
  • Nakano, D. et al. Multiphoton imaging of the glomerular permeability of angiotensinogen. Journal of the American Society of Nephrology : JASN 23, 1847-1856, (2012).
  • Peti-Peterdi, J., Burford, J. L. & Hackl, M. J. The first decade of using multiphoton microscopy for high-power kidney imaging. Am J Physiol Renal Physiol 302, F227-233, (2012).
  • Salmon, A. H. et al. Loss of the endothelial glycocalyx links albuminuria and vascular dysfunction. Journal of the American Society of Nephrology : JASN 23, 1339-1350, (2012).
  • Sarkisyan, G., Cahalan, S. M., Gonzalez-Cabrera, P. J., Leaf, N. B. & Rosen, H. Real-time differential labeling of blood, interstitium, and lymphatic and single-field analysis of vasculature dynamics in vivo. Am J Physiol Cell Physiol 302, C1460-1468, (2012).
  • Voiculescu, O. & Stern, C. D. Assembly of imaging chambers and high-resolution imaging of early chick embryos. Cold Spring Harb Protoc 2012, pdb.prot072314-, (2012).
  • Abdulreda, M. H. et al. High-resolution, noninvasive longitudinal live imaging of immune responses. Proceedings of the National Academy of Sciences of the United States of America 108, 12863-12868, (2011).
  • Hefendehl, J. K. et al. Long-term in vivo imaging of beta-amyloid plaque appearance and growth in a mouse model of cerebral beta-amyloidosis. The Journal of neuroscience : the official journal of the Society for Neuroscience 31, 624-629, (2011).
  • Lei, Y. et al. Transretinal degeneration in ageing human retina: a multiphoton microscopy analysis. Br J Ophthalmol 95, 727-730, (2011).
  • Li, G. et al. Physiology and cell biology of acupuncture observed in calcium signaling activated by acoustic shear wave. Pflugers Archiv : European journal of physiology 462, 587-597, (2011).
  • Martinez-Lemus, L. A., Zhao, G., Galinanes, E. L. & Boone, M. Inward remodeling of resistance arteries requires reactive oxygen species-dependent activation of matrix metalloproteinases. Am J Physiol Heart Circ Physiol 300, H2005-2015, (2011).
  • Nakamoto, H., Yada, T., Ogasawara, Y. & Kajiya, F. Glomerular Filtration at the Early Stage of Diabetes. FASEB J 25, 664.617-, (2011).
  • Coppieters, K., Martinic, M. M., Kiosses, W. B., Amirian, N. & von Herrath, M. A novel technique for the in vivo imaging of autoimmune diabetes development in the pancreas by two-photon microscopy. PLoS One 5, e15732, (2010).
  • Gligorijevic, B., Kedrin, D., Segall, J. E., Condeelis, J. & van Rheenen, J. Dendra2 photoswitching through the Mammary Imaging Window. J Vis Exp, 1278, (2009).
  • Speier, S. et al. Noninvasive high-resolution in vivo imaging of cell biology in the anterior chamber of the mouse eye. Nature protocols 3, 1278-1286, (2008).
  • Lunemann, A. et al. Macrophage/microglia activation factor expression is restricted to lesion-associated microglial cells after brain trauma. Glia 53, 412-419, (2006).
  • Stepulak, A. et al. NMDA antagonist inhibits the extracellular signal-regulated kinase pathway and suppresses cancer growth. Proceedings of the National Academy of Sciences of the United States of America 102, 15605-15610, (2005).
  • Manconi, F., Kable, E., Cox, G., Markham, R. & Fraser, I. S. Whole-mount sections displaying microvascular and glandular structures in human uterus using multiphoton excitation microscopy. Micron 34, 351-358, (2003).
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