STELLARIS 5 & STELLARIS 8 Confocal Microscopes Products Home Leica Microsystems

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Confocal Microscope Platforms STELLARIS 5 & STELLARIS 8

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  • Transverse histological cut of a rabbit tongue. 50 Mpixels images (2326 µm x 1739 µm) in 14 x 18 tiles. Lifetime gives an additional contrast that allows to differentiate different structures in histological stainings.

    A Guide to Fluorescence Lifetime Imaging Microscopy (FLIM)

    The fluorescence lifetime is a measure of how long a fluorophore remains on average in its excited state before returning to the ground state by emitting a fluorescence photon.
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  • Tubulin - TauInteraction

    TauInteraction – Studying Molecular Interactions with TauSense

    Fluorescence microscopy constitutes one of the pillars in life sciences and is a tool commonly used to unveil cellular structure and function. A key advantage of fluorescence microscopy resides in the…
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  • Depth coding of endothelial cells in zebrafish eye. Courtesy of Basile Gurchenkov, Imaging Center of the IGBMC, Illkirch-Graffenstaden, France.

    Gentle 3D Imaging of Biological Samples

    For 3D imaging of biological samples, light sheet microscopy is a powerful and sensitive tool allowing you to measure (sub)cellular dynamics over long periods of time. Meanwhile, confocal microscopy,…
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  • Identification of distinct structures_roundworm_Ascaris_female

    Find Relevant Specimen Details from Overviews

    Switch from searching image by image to seeing the full overview of samples quickly and identifying the important specimen details instantly with confocal microscopy. Use that knowledge to set up…
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  • Confocal imaging of a SARS-CoV-2-infected epithelia at 4 dpi (orthogonal sections)

    STELLARIS Contributes to Understanding COVID-19 Infection

    What are the structural and functional consequences of a SARS-CoV-2 infection? To answer this important question, the authors used 3D cultures that mimic an airway epithelium and used different…
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  • AiviaMotion: Truly simultaneous multicolor imaging of live cells (U2OS) in 3D

    Artificial Intelligence and Confocal Microscopy – What You Need to Know

    This list of frequently asked questions provides “hands-on” answers and is a supplement to the introductory article about AiviaMotion "How Artificial Intelligence Enhances Confocal Imaging"
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  • How Artificial Intelligence Enhances Confocal Imaging

    In this article, we show how artificial intelligence (AI) can enhance your imaging experiments. Namely, how AiviaMotion improves image quality while capturing the temporal dynamics of your live-cell…
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  • Spectroscopic Evaluation of Red Blood Cells

    Hemoglobinopathies are a major healthcare problem. This study presents a possible diagnostic tool for thalassemia which is based on confocal spectroscopy. This approach exploits spectral detection and…
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  • Visualizing Protein Degradation and Aggregation in the Living Cell

    Our guest speaker, Prof Dr Eric Reits, presents his work on neurodegenerative disorders. Reits’ group are experts on the subject of Huntington’s disease and work towards identifying leads for…
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  • Life Beyond the Pixels: Deep Learning Methods for Single Cell Analysis

    Our guest speaker Prof Dr Peter Horvath presents his work on single cell-based large-scale microscopy experiments. This novel targeting approach includes the use of machine learning models and…
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  • Adding Dimensions to Multiplex Molecular Imaging

    Molecular imaging of living specimens offers a means to draw upon the growing body of high-throughput molecular data to better understand the underlying cellular and molecular mechanisms of complex…
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  • Benefits of TauContrast to Image Complex Samples

    In this interview, Dr. Timo Zimmermann talks about his experience with the application of TauSense tools and their potential for the investigation of demanding samples such as thick samples or…
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  • A New World of Confocal Applications with the Next Generation White Light Lasers

    As biological questions get more complex, there is an increasing need to study multiple events simultaneously in the same specimen. When preparing the specimen for imaging experiments, this need is…
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  • Image courtesy of Dr. Stefan Finke, Friedrich-Loeffler- Institute, Riems, Germany.

    How Can Immunofluorescence Aid Virology Research?

    Modern virology research has become as crucial now as ever before due to the global COVID-19 pandemic. There are many powerful technologies and assays that virologists can apply to their research into…
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  • Obtain maximum information from your specimen with LIGHTNING

    LIGHTNING is an adaptive process for extraction of information that reveals fine structures and details, otherwise simply not visible, fully automatically. Unlike traditional technologies, that use a…
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  • Expanding the frontiers of confocal live cell imaging

    To address the specific challenges of live cell confocal imaging and help researchers get closer to the truth, Leica Microsystems has re-imagined confocal microscopy, designing its entirely new…
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  • Nanoscopy meets Lifetime: Introducing TauSTED

    τ-STED combines the optical signals from STED and the photophysical information from the fluorescence lifetime at unprecedented speeds. This approach to STED uses phasor analysis in a novel way.…
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  • Explore Innovative Techniques to Separate Fluorophores with Overlapping Spectra

    In this article we explore several strategies you can take to improve the separation of fluorophores and increase the number of fluorescent probes you can distinguish in your sample.
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  • COS7 mitotic cells: chromatin (cyan, mCherry), mitotic spindle (yellow, EGFP), Golgi (red, Atto647N), mitochondria (green, AF532), and actin filaments (magenta, SiR700). Sample courtesy of Jana Döhner and Urs Ziegler, University of Zurich, Switzerland. Cells expressing mCherry were a kind gift of Daniel Gehrlich and SiR was a kind gift of Spirochrome. Image acquired with STELLARIS.

    STELLARIS White light lasers

    When it comes to choosing fluorescent probes for your multi-color experiments, you shouldn’t have to compromise. Now you can advance beyond conventional excitation sources that limit your fluorophore…
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  • TauSense Technology Imaging Tools

    Leica Microsystems’ TauSense technology is a set of imaging modes based on fluorescence lifetime. Found at the core of the STELLARIS confocal platform, it will revolutionize your imaging experiments.…
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  • The Power HyD detector family

    Powerful photon counting detectors on the STELLARIS confocal platform provide improved photon counting, ultra-sensitive imaging and more color options in the NIR spectrum.
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  • How to Uncover Hidden Dimensions in Research with Lifetime Imaging

    Learn how fluorescence lifetime imaging adds information depth to your confocal experiments and reveals novel insights that are difficult or impossible to discover using conventional intensity-based…
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  • Learn how to Remove Autofluorescence from your Confocal Images

    Autofluorescence can significantly reduce what you can see in a confocal experiment. This article explores causes of autofluorescence as well as different ways to remove it, from simple media fixes to…
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  • Fields of Application

  • This confocal image shows one scan layer of the acoel worm Isodiametra pulchra. The following parts are stained: cyan: nuclei, green: stem cells, magenta: expression of the genes T-Brain/Eomes (gonads und oocytes). Left: anterior. The worm is about 1 mm of size. Photo: Aina Børve, Sars

    Live Cell Imaging

    Shifting perspective from single microscope components to a full working live cell imaging solution, Leica Microsystems integrates microscope, LAS X imaging software, cameras, and dedicated…
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  • Super-Resolution

    Find out more about Leica super-resolution microscopy solutions and how they can empower you to visualize in fine detail subcellular structures and dynamics.
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  • Cancer Research

    Cancer is a complex and heterogeneous disease caused by cells deficient in growth regulation. Genetic and epigenetic changes in one or a group of cells disrupt normal function and result in…
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  • Organoids and 3D Cell Culture

    One of the most exciting recent advancements in life science research is the development of 3D cell culture systems, such as organoids, spheroids, or organ-on-a-chip models. A 3D cell culture is an…
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  • Neuroscience

    Are you working towards a better understanding of neurodegenerative diseases or studying the function of the nervous system? See how you can make breakthroughs with imaging solutions from Leica…
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  • Fluorescence Microscopy Solutions

    Find out how fluorescence microscopes from Leica Microsystems support your research. Fluorescence is one of the most commonly used physical phenomena in biological and analytical microscopy for its…
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  • Fluorescence Lifetime Imaging Solutions

    Leica Microsystems’ solutions for FLIM allow you to uncover a new dimension of imaging and make it simple to integrate into established protocols. Fluorescence lifetime imaging microscopy (FLIM) is an…
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  • Leica Cell Biology

    Cell Biology

    When your research is centered on understanding the cellular basis of human health and disease, it is critical to investigate the cells of interest in spatiotemporal and molecular detail.…
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  • Virology

    Do your research interests focus on viral infection and disease? Find out how you can gain insights into virology with solutions for imaging and sample preparation from Leica Microsystems.
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  • Model Organisms in Research

    A model organism is a species used by researchers to study specific biological processes. They have similar genetic characteristics to humans and are commonly used in research areas such as genetics,…
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