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Tissue Image Gallery

Tissue imaging with Leica Microsystems instruments

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Visual analysis of animal and human tissues is critical to understand complex diseases such as cancer or neurodegeneration. From basic immunohistochemistry to intravital imaging, confocal microscopy and advanced modalities can provide an understanding of cells, biomolecules and their interactions within their environment.

Tissue imaging with STELLARIS confocal platform

The STELLARIS confocal platform gives you access to multiphoton imaging, STED super-resolution, fluorescence lifetime imaging microscopy (FLIM), and Digital Light Sheet (DLS), to image the most demanding tissue samples. This gallery shows images from tissue obtained with the STELLARIS confocal platform.

3D STED 775 deep nanoscopy of glomerulus in cleared kidney tissue

3D STED 775 deep nanoscopy of glomerulus in cleared kidney tissue immunostained for nephrin.
3D STED 775 deep nanoscopy of glomerulus in cleared kidney tissue immunostained for nephrin. Scale bar: 10 μm, z-depth color coded. Image taken with STELLARIS confocal platform. Sample courtesy: David Unnersjö Jess, KTH, Stockholm, Sweden.

4 colour live imaging of mouse brain cortex​

Neurodegenerative diseases are usually caused by a combination of different factors. Being able to visualize multiple players at once greatly helps to investigate and understand how different compoonents interact and influence each other. To do this, a microscope that combines deep tissue penetration with spectral flexibility to enable multicolor imaging liek STELLARIS 8 DIVE is the best choice.

Live Mouse Brain cortex
Live Mouse Brain cortex. Images acquired on a multiphoton DIVE microscope. Astrocytes labeled with Sulforhodamine (blue); Microglia labeled with GFP (green), Neurons labeled with YFP (yellow) and bood vessels labeled with Alexa680-Dextran (red). Sample courtesy of LMF, DZNE, Germany 

Multicolor Deep In Vivo Imaging to uncover the interplay of various players in neurodegenerative diseases

Neurodegenerative diseases are usually caused by a combination of different factors. Being able to visualize multiple players at once greatly helps to investigate and understand how different compoonents interact and influence each other. To do this, microscope that combines deep tissue penetration with spectral flexibility to enable multicolor imaging like STELLARIS 8 DIVE is the best choice.

Live Mouse Brain cortex: Microglia labeled with GFP (green), Neurons labeled with YFP (yellow) and bood vessels labeled with Alexa680-Dextran (red). Sample courtesy of LMF, DZNE, Germany

Expand the potential of deep in vivo experiments with label-free imaging​

Molecules such as collagen and elastin have relevant roles in diseases like cancer. Our 4-tune detector enables the use of second and third harmonic generation signals that allow you to study these important structures without staining.​ The combination of DIVE with STELLARIS also enables the use of lifetime-based information intrinsic to fluorescence. This ability allows you to perform experiments like metabolic mapping of a specimen via lifetime imaging of NADH or FAD.​

Confetti mouse small intestines
Confetti mouse small intestines: Collagen1 is shown in gray (label free SHG) and lineage traced stem cells are shown in cyan, green, yellow, and red. Stem cells play an important role in the spread of cancer within organisms. Sample courtesy of Jacco van Rheenen, Netherlands Cancer Institute, NL.

Understand cancer better with deep in vivo imaging

Multiphoton systems are usually rigid to use and need to be adapted to each experiment and user. Add to this the stress of working with live animals or freshly explanted tissue and you quickly understand the advantage of having flexibility when doing multiphoton experiments. STELLARIS 8 DIVE provides you with an easy, hassle-free workflow from setup to final results thanks to the seamless integration of multiphoton capabilities into the STELLARIS software.

Understand cancer better with deep in vivo imaging
Understand cancer better with deep in vivo imaging

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