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Digital Light Sheet Microscope STELLARIS DLS

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  • Microscopic images of GFP labelled vomeronasal sensory neuron axons forming glomeruli in the accessory olfactory bulb. Images acquired with a digital light sheet microscope from Leica Microsystems.

    Investigating Axonal Pathfinding in the Accessory Olfactory System

    Hernandez-Clavijo et. al. investigated the importance of TMEM16A, a calcium-activated chloride channel, for axonal pathfinding between the VNO and AOB and its effect on VSN density within the VNO.…
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  • Wt1b-positive myocardial cell adopting an epicardial cell morphology. (See full time lapse movie below.)

    Wt1 Genes Can Induce a Cardiomyocyte to Epicardial-like Cell Fate Transition

    From this study, it was concluded that Wt1 plays a yet undescribed role for cardiomyocyte differentiation by repressing chromatin opening at specific genomic loci and that sustained ectopic expression…
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  • Depth coding of endothelial cells in zebrafish eye. Courtesy of Basile Gurchenkov, Imaging Center of the IGBMC, Illkirch-Graffenstaden, France.

    Gentle 3D Imaging of Biological Samples

    For 3D imaging of biological samples, light sheet microscopy is a powerful and sensitive tool allowing you to measure (sub)cellular dynamics over long periods of time. Meanwhile, confocal microscopy,…
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  • Dual color volume rendering of Drp1 oligomers (green) and mito OM (red) in a live U2OS cell

    Multicolor 4D Super Resolution Light Sheet Microscopy

    The AI Microscopy Symposium offers a unique forum for discussing the latest AI-based technologies and tools in the field of microscopy and biomedical imaging. In this scientific presentation, Yuxuan…
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  • Imaging of Anti-Cancer Drug Uptake in Spheroids using DLS

    Spheroid 3D cell culture models mimic the physiology and functions of living tissues making them a useful tool to study tumor morphology and screen anti-cancer drugs. The drug AZD2014 is a recognized…
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  • Effects of Clearing Media on Tissue Transparency and Shrinkage

    This study comprehensively evaluates the effects of different clearing media on tissue transparency and shrinkage by comparing freshly dissected dipteran fly brains with their cleared equivalents.…
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  • Following Ca²⁺ Changes in Acutely Stimulated Spheroids

    Spheroids are easy and cost-effective 3D cell cultures, useful for fundamental and applied research. They can bridge the gap between 2D and in vivo experiments and can be used for high-throughput…
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  • Analyzing Structural and Functional Testicular Anatomy

    Fleck, Kenzler et al. have shown that, in mice, muscle-like cells are located within the walls of seminiferous tubules. Using CLARITY and a Leica digital light-sheet (DLS) microscope, Fleck, Kenzler…
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  • Fish and Chips Sheet into the Light

    The zebrafish larval brain is small and contains about 1 million times less neurons than the human counterpart. The neural circuitry and the general bauplan of the vertebrate brain, however, is…
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  • Understanding Motor Sequence Generation Across Spatiotemporal Scales

    We have developed a microscopy-based pipeline to characterize a developmentally critical behavior at the pupal stage of development, called the ecdysis sequence. We study brain-wide neuronal activity…
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  • A Quality Metric for the Systematic Evaluation of Clearing Protocols

    3D multicellular spheroids are of interest for studying tumor behavior and evaluating the response of pharmacologically active agents, because they mimic the in vivo tumor environment better than…
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  • Fields of Application

  • Organoids and 3D Cell Culture

    One of the most exciting recent advancements in life science research is the development of 3D cell culture systems, such as organoids, spheroids, or organ-on-a-chip models. A 3D cell culture is an…
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  • Model Organisms in Research

    A model organism is a species used by researchers to study specific biological processes. They have similar genetic characteristics to humans and are commonly used in research areas such as genetics,…
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  • This confocal image shows one scan layer of the acoel worm Isodiametra pulchra. The following parts are stained: cyan: nuclei, green: stem cells, magenta: expression of the genes T-Brain/Eomes (gonads und oocytes). Left: anterior. The worm is about 1 mm of size. Photo: Aina Børve, Sars

    Live Cell Imaging

    Shifting perspective from single microscope components to a full working live cell imaging solution, Leica Microsystems integrates microscope, LAS X imaging software, cameras, and dedicated…
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