Light Sheet Re-Imagined
Digital Light Sheet Microscope STELLARIS DLS
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Wt1 Genes Can Induce a Cardiomyocyte to Epicardial-like Cell Fate Transition
From this study, it was concluded that Wt1 plays a yet undescribed role for cardiomyocyte differentiation by repressing chromatin opening at specific genomic loci and that sustained ectopic expression…
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Gentle and Flexible 3D Imaging of Biological and Cleared Samples
For 3D imaging of biological samples, light sheet microscopy is a powerful and sensitive tool allowing you to measure (sub)cellular dynamics over long periods of time. Meanwhile, confocal microscopy,…
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Science Lab Topic:
Live-Cell Imaging
Multicolor 4D Super Resolution Light Sheet Microscopy
The AI Microscopy Symposium offers a unique forum for discussing the latest AI-based technologies and tools in the field of microscopy and biomedical imaging. In this scientific presentation, Yuxuan…
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Science Lab Topic:
Light Sheet Microscopy
Imaging of Anti-Cancer Drug Uptake in Spheroids using DLS
Spheroid 3D cell culture models mimic the physiology and functions of living tissues making them a useful tool to study tumor morphology and screen anti-cancer drugs. The drug AZD2014 is a recognized…
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Science Lab Topic:
Light Sheet Microscopy
Effects of Clearing Media on Tissue Transparency and Shrinkage
This study comprehensively evaluates the effects of different clearing media on tissue transparency and shrinkage by comparing freshly dissected dipteran fly brains with their cleared equivalents.…
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Science Lab Topic:
Light Sheet Microscopy
Following Ca²⁺ Changes in Acutely Stimulated Spheroids
Spheroids are easy and cost-effective 3D cell cultures, useful for fundamental and applied research. They can bridge the gap between 2D and in vivo experiments and can be used for high-throughput…
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Science Lab Topic:
Light Sheet Microscopy
Analyzing Structural and Functional Testicular Anatomy
Fleck, Kenzler et al. have shown that, in mice, muscle-like cells are located within the walls of seminiferous tubules. Using CLARITY and a Leica digital light-sheet (DLS) microscope, Fleck, Kenzler…
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Science Lab Topic:
Light Sheet Microscopy
Fish and Chips Sheet into the Light
The zebrafish larval brain is small and contains about 1 million times less neurons than the human counterpart. The neural circuitry and the general bauplan of the vertebrate brain, however, is…
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Science Lab Topic:
Light Sheet Microscopy
Understanding Motor Sequence Generation Across Spatiotemporal Scales
We have developed a microscopy-based pipeline to characterize a developmentally critical behavior at the pupal stage of development, called the ecdysis sequence. We study brain-wide neuronal activity…
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Science Lab Topic:
Light Sheet Microscopy
A Quality Metric for the Systematic Evaluation of Clearing Protocols
3D multicellular spheroids are of interest for studying tumor behavior and evaluating the response of pharmacologically active agents, because they mimic the in vivo tumor environment better than…
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Fields of Application
Organoids and 3D Cell Culture
One of the most exciting recent advancements in life science research is the development of 3D cell culture systems, such as organoids, spheroids, or organ-on-a-chip models. A 3D cell culture is an…
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Model Organisms in Research
A model organism is a species used by researchers to study specific biological processes. They have similar genetic characteristics to humans and are commonly used in research areas such as genetics,…
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Live Cell Imaging
Shifting perspective from single microscope components to a full working live cell imaging solution, Leica Microsystems integrates microscope, LAS X imaging software, cameras, and dedicated…
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