Decode 3D biology in real time*

THUNDER Imager Model Organism

The THUNDER Imager Model Organism allows fast and easy 3D exploration of whole organisms for developmental or molecular biology research. Thanks to Computational Clearing, your images reveal the finest structural details. No hassle with out-of-focus blur while maintaining the capabilities and ease-of-use typical for Leica stereo microscopes.

A THUNDER Imager Model Organism is the optimal instrument for studying, e.g., Drosophila, C. elegans, zebrafish, plants, and mice. One device for screening, positioning, and imaging your specimen. Simplify your workflow and study model organisms from a large overview to the highest detail.

Advantages for your research are:

  • Rapid acquisition of blur-free images showing fine details, even from deep within thick organisms
  • Keep even large model organisms under excellent physiological conditions during imaging
  • Simplify your organism handling for a more efficient imaging and analysis workflow

*in accordance with ISO/IEC 2382:2015

THUNDER Imager Model Organsim with 1x Plan APO objective, zoom factor 11:1, 18 z-slice stack, circa 300 um z-depth. Green (kdrl:GFP) shows angiogenisis and red (GATA1:dsRed) shows red blood cells and platelets.

Image courtesy: Dr. Almary Guerra & Dr. Didier Stainier, Max Planck Institute for Heart and Lung Research, Bad Nauheim (Germany)

Blur-free images with fine details

Get the most information from your precious model organisms and access stunning details. Take advantage of the leap forward in image quality with THUNDER Imager Model Organism compared to conventional stereo microscopes. Thanks to THUNDER, non-relevant background is removed and interesting details are preserved.

Obtain results faster and with higher significance for applications like:

  • Characterization of model organism transgenic lines
  • Detailed observation of model organisms in real time
  • Investigating development of neuronal networks

Image large model organisms under excellent physiological conditions

Have the best of both worlds: THUNDER Imager Model Organism combines a large field of view with high image quality for thick samples that was, so far, only possible with optical sectioning methods. This powerful combination allows you to observe large specimens live under excellent physiological conditions. No need to sedate your organisms.

Gain more insights for a better understanding of the phenomena under investigation. Z-scans through the entire volume of a fish are possible thanks to the excellent optics and removal of out-of-focus signals. Get fast results as just one image per z-plane is required.

With THUNDER Imager Model Organism, you can observe the relevant details in the proper context with a large field of view. With instant Computational Clearing, you can acquire fast z-stack images and use highly sensitive cameras for detection under physiological conditions.

Mouse
Mouse with THUNDER Imager Model Organism

In this E12-14 mouse (wt sample), neurofilaments are stained in red to assess neuronal outgrowth. The mouse was cleared with the ScaleS reagent. Sample courtesy Yves Lutz, Centre d’imagerie, IGBMC (France).

Explore new terrain

The THUNDER Imager Model Organism helps to simplify the screening and documentation of live model organisms for specific details. Live, moving organisms can be imaged directly in petri dishes or multiwell plates. With the optional 2x corr objective, you can observe specimens in water with sharp focus. There is no need to extract or cut the specimen into sections. Just obtain the relevant data directly.

Time-lapse studies of model organisms are important for looking at development, movement, and reaction. With THUNDER, you obtain images with highly resolved details at the speed of your camera, in real time.

THUNDER Imager for deep insights

Take advantage of the large working distances typical for stereo microscopes.

THUNDER Imager Model Organism can make z-stack images, which was not possible before.

Look at large organoids and cleared or uncleared mouse organs directly in the petri dish.

Your results will be highly valuable and simply impressive.

Z-stack of Organoid
Z-stack of Organoid with THUNDER Imager Model Organism

An organoid approximately 150 µm in diameter mounted onto a depression slide. Imaged with a stereo microscope using a high resolution objective (FluoCombi III) [left] and a THUNDER Imager Model Organism (right). The THUNDER Imager system delivers a sharper image with higher resolution.

3 Dedicated Configurations

The THUNDER Imager Model Organism are available in 3 dedicated configurations:

  1. Optimized for large fields of view. It is equipped with a 20 megapixel digital camera and a THUNDER 3D station for maximal image processing capabilities.
  2. Optimized to capture even the faintest signals. It is equipped with a state-of-the-art sCMOS, B&W camera, and a THUNDER 3D station for maximal processing capabilities.
  3. Optimized for investigating fast intracellular processes and capable of Instant Computational Clearing (ICC). It is equipped with a state-of-the-art sCMOS camera.

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