Designing your Research Study with Multiplexed IF Imaging

Angus-Hill, Melinda

October 28, 2021

Designing your Research Study with Multiplexed IF Imaging

Webinar On-Demand

Multiplexed tissue analysis is a powerful technique that allows comparisons of cell-type locations and cell-type interactions within a single fixed tissue sample. It is common for researchers to ask these questions before a multiplexing study begins: "How do I know what biomarkers are relevant in the tissue? Also, how do I pivot towards additional biomarkers as my research questions evolve?" Smart study design can help answer existing questions and enable continued exploration of new connections that weren’t immediately obvious at the beginning of the study.

Multiplexed IF imaging can replace historical immunohistochemical staining, allowing researchers to explore more in-depth questions on the same piece of tissue. This exploration doesn't have to stop when the study ends. As research progresses, new discoveries of relationships can result in new hypotheses and additional biomarker analysis can be layered upon existing biomarker imaging data, even months or years later.

Choosing the right multiplexed solution can have a huge impact on the success of your research. The solution must be adaptable as researchers cannot be hindered by years of validation. The workflow must employ a gentle process and be tissue preserving, so biomarkers added later in the study are encountering the same tissue quality as those used earlier in the study. Cell DIVE is a proven and trusted multiplexed imaging solution that meets these requirements and more.

Speaker: Melinda Angus-Hill, Ph.D. - Lead Scientist, Cell DIVE

Melinda Angus-Hill, Ph.D. is the Lead Scientist for the Cell DIVE Multiplexed Imaging Solution at Leica Microsystems. She completed a Ph.D. in Oncological sciences and a postdoctoral fellowship in translational cancer research and genetics, where she developed mouse models of human disease. Prior to joining Leica, she was a Validation Scientist for the Cell DIVE, super-resolution and high content imaging solutions, where she represented the voice of customer perspective, and provided technical expertise and application validation support. Melinda has also previously led a research laboratory as a Principal Investigator and Assistant Professor at the Huntsman Cancer Institute in Utah, US, where she studied the effects of mind body medicine and stress reduction on the tumor microenvironment and tumor progression in colorectal cancer models.

Learning Objectives:

Review the basics of study design with a focus on when to use multiplexed imaging
Compare and contrast descriptive research with discovery and mechanism based research
Evaluating the requirements for a multiplexed imaging solution

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