Dissecting Proteomic Heterogeneity of the Tumor Microenvironment


This lecture will highlight cutting edge applications in applying laser microdissection and microscaled quantitative proteomics and phosphoproteomics to uncover exquisite intra- and inter-tumor heterogeneity. The paradigm-shifting results offer unprecedented opportunities to speed progress in identifying novel molecular sub-types of cancer, therapeutic targets, prognostic signatures, and companion diagnostics.

Learning Objectives

  • Understand how laser microdissection is used to enrich discrete cellular populations from the tumor microenvironment.
  • Understand the fundamental workflow for conducting quantitative proteomics and phosphoproteomics.

Understand the benefit of focused expression-based analyses of microcompartment enriched specimens to illuminate stromal- and tumor-specific biology.


Thomas P. Conrads, Ph.D., Director of Women’s Health Research, Inova Health System

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