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How do Cells Talk to Each Other During Neurodevelopment?

In this webinar, discover the role that extracellular signalling mechanisms play in the correct development of the human brain. Wednesday 24th April, 3-4pm London | 4-5pm Berlin | 6-7pm Dubai

The role of extracellular signalling mechanisms in the correct development of the human brain The_role_of_extracellular_signalling_mechanisms_in_the_correct_development_of_the_human_brain.jpg

Cellular crosstalk is an essential process during brain development and is influenced by numerous factors, including the morphology of the cells, their adhesion molecules, the local extracellular matrix, and the secreted vesicles. In this webinar, discover how a deeper understanding of these mechanisms is advancing the understanding of neurodevelopmental disorders.

About the webinar

Key webinar learnings:

  • How the in vivo mouse model and in vitro human-derived neurons, cerebral organoids, and dorsoventral assembloids are combined to better understand and tackle the causes of neurodevelopmental disorders.
  • The molecular and cellular mechanisms involved in ventral progenitors’ proliferation and fate.
  • The migration and maturation of inhibitory neurons during human brain development.

Extracellular signaling in neurodevelopmental disorders

Inspired by mutations associated with neurodevelopmental disorders, Prof. Dr. Silvia Cappello’s group at LMU focuses on the basic molecular and cellular mechanisms that regulate the development of the human brain, with a particular focus on extracellular mechanisms.

The group combine the in vivo mouse model and the in vitro human-derived neurons, cerebral organoids, and dorso-ventral assembloids in order to better understand the mechanisms involved in ventral progenitors’ proliferation and fate as well as migration and maturation of inhibitory neurons during human brain development and tackle the causes of neurodevelopmental disorders. They particularly focus on mutations in genes influencing cell-cell contacts, extracellular matrix, and secretion of vesicles and therefore study intrinsic and extrinsic mechanisms contributing to the formation of the brain. The data reveals an important contribution of cell non-autonomous mechanisms in the development of neurodevelopmental disorders.

Throughout the webinar, Silvia will also show how imaging workflows, using the Mica Imaging Microhub alongside confocal and super-resolution systems, are supporting the group’s research.

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