Cell Biology Research
When your research is centered on understanding the cellular basis of human health and disease, it is critical to investigate the cells of interest in spatiotemporal and molecular detail. Consequently, microscopy is an ever-important tool in cell biology, allowing you to study your specimens in detail within their structural environment, as well as, analyze cellular organelles and macromolecules. Cell biology imaging is done with a range of light and electron microscopes. Imaging solutions offered by Leica Microsystems are designed to maximize your cell biology research.
The challenges faced when using microscopy for cell biology research vary, as the imaging of inter- and intra-cellular events requires a range of samples that vary in size and complexity. Imaging of these events needs to be performed from the nanometer to the millimeter scale.
Additionally, the study of cells under the microscope is further influenced by whether they are live or fixed samples, as these cases pose different imaging challenges. One challenge is how to capture fast dynamic events with the right resolution. Another one, for any cellular structures or events that do not produce a natural contrast during imaging, is choosing the right fluorescent proteins, antibodies, or nucleic acid probes to use as tags for specific proteins, DNAs, and RNAs in the cell to be viewed with fluorescence microscopy.
Choosing the right microscopy method is critical if you want to maximize your research output and obtain the highest quality data.
Leica Microsystems offers various solutions to improve your cell biology research. These range from digital imagers that enhance daily cell culture tasks to high-end imaging solutions that enable the study of single molecules in detail or maximize the amount of results you get from your sample.
THUNDER Imagers provide you with a solution for advanced 3D cell culture assays, whether you want to study stem cells, spheroids, or organoids. THUNDER Imager 3D Live Cell & 3D Cell Culture meets your requirements to study cells close to their physiological state by optimizing experimental conditions, e.g., the lowest light intensity and shortest exposure times possible.
Experience the power to see more within your cells, with enhanced image quality, the possibility to image more markers within one sample at the same time, and the capacity to make detailed observations without influencing or damaging your sample with STELLARIS confocal microscope platform.
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With the STELLARIS confocal platform, we have re-imagined confocal microscopy to get you closer to the truth.
sCMOS Microscope Camera
The THUNDER Imager EM Cryo CLEM enables precise identification of cellular structures and smooth, secure transfer of coordinates, images, and samples through your correlative workflow.
Ultramicrotome for array tomography
Multicolor advanced TIRF module
Image of C2C12 cells
The cells are stained with lamin B (magenta) which indicates nuclear structure, Hoechst (blue) indicating DNA, and γH2AX (yellow) indicating damage to DNA. Cells were imaged using a THUNDER Imager 3D Live Cell with a 63X/1.4 oil immersion objective.
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The knowledge portal of Leica Microsystems offers scientific research and teaching material on the subjects of microscopy. The content is designed to support beginners, experienced practitioners and scientists alike in their everyday work and experiments.