Cell Biology Research
When your research is centered on understanding the cellular basis of human health and disease, it is critical to investigate the cells of interest in spatiotemporal and molecular detail. Consequently, microscopy is an ever-important tool in cell biology, allowing you to study your specimens in detail within their structural environment, as well as, analyze cellular organelles and macromolecules. Cell biology imaging is done with a range of light and electron microscopes. Imaging solutions offered by Leica Microsystems are designed to maximize your cell biology research.
Contact a local specialist for advice on the right cell biology system for your needs.
Challenges with cellular imaging
The challenges faced when using microscopy for cell biology research vary, as the imaging of inter- and intra-cellular events requires a range of samples that vary in size and complexity. Imaging of these events needs to be performed from the nanometer to the millimeter scale.
Additionally, the study of cells under the microscope is further influenced by whether they are live or fixed samples, as these cases pose different imaging challenges. One challenge is how to capture fast dynamic events with the right resolution. Another one, for any cellular structures or events that do not produce a natural contrast during imaging, is choosing the right fluorescent proteins, antibodies, or nucleic acid probes to use as tags for specific proteins, DNAs, and RNAs in the cell to be viewed with fluorescence microscopy.
Finding the right solution for cellular imaging
Choosing the right microscopy method is critical if you want to maximize your research output and obtain the highest quality data.
Leica Microsystems offers various solutions to improve your cell biology research. These range from digital imagers that enhance daily cell culture tasks to high-end imaging solutions that enable the study of single molecules in detail or maximize the amount of results you get from your sample.
THUNDER Imager
THUNDER Imagers provide you with a solution for advanced 3D cell culture assays, whether you want to study stem cells, spheroids, or organoids. THUNDER Imager 3D Live Cell & 3D Cell Culture meets your requirements to study cells close to their physiological state by optimizing experimental conditions, e.g., the lowest light intensity and shortest exposure times possible.
Infinity TIRF
TIRF is ideal for imaging dynamic processes and the method of choice for visualizing single molecules with super-resolution.
STELLARIS
Experience the power to see more within your cells, with enhanced image quality, the possibility to image more markers within one sample at the same time, and the capacity to make detailed observations without influencing or damaging your sample with STELLARIS confocal microscope platform.
Cell biology related products
Filter by Area of Application
STELLARIS
With the STELLARIS confocal platform, we have re-imagined confocal microscopy to get you closer to the truth.
K5
sCMOS Microscope Camera
THUNDER Imager EM Cryo CLEM
The THUNDER Imager EM Cryo CLEM enables precise identification of cellular structures and smooth, secure transfer of coordinates, images, and samples through your correlative workflow.
ARTOS 3D
Ultramicrotome for array tomography
Infinity TIRF
Multicolor advanced TIRF module
Featured image
Image of C2C12 cells
The cells are stained with lamin B (magenta) which indicates nuclear structure, Hoechst (blue) indicating DNA, and γH2AX (yellow) indicating damage to DNA. Cells were imaged using a THUNDER Imager 3D Live Cell with a 63X/1.4 oil immersion objective.
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Cell biology related articles
Advancing Cell Biology with Cryo-Correlative Microscopy
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Confluency Check with PAULA Cell Imager
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California NanoSystems Institute at UCLA Publications
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Introduction to Mammalian Cell Culture
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Five Questions Asked: Prof. Dr. Jacco van Rheenen speaks about the most important considerations when imaging deep into mouse tissue
When operating a confocal microscope, or when discussing features and parameters of such a device, we inescapably mention the pinhole and its diameter. This short introductory document is meant to…Read article
Human NK Cell Development Requires CD56-mediated Motility and Formation of the Developmental Synapse
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Variety of RNAs in Peripheral Blood Cells, Plasma, and Plasma Fractions
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The Bif-1-Dynamin 2 Membrane Fission Machinery Regulates Atg9-Containing Vesicle Generation at the Rab11-Positive Reservoirs
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