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Intraoperative OCT-Assisted Gene Therapy
Intraoperative OCT Augments Surgical Safety and Accuracy of Treatment Delivery in Subretinal Gene Augmentation Therapy
Gene augmentation therapy is a method of ocular gene transfer for autosomal recessive or X-linked retinal dystrophies when there is insufficient functional protein manifesting as genetic disease. These genetic defects cause specific visual impairments and/or retinal degeneration. There has been a recent explosion in interest in gene therapy applications for retinal dystrophies. The surgical technique for subretinal injection of gene therapy is technically demanding and challenging. Intraoperative optical coherence tomography (Intraoperative OCT) provides real-time information and surgeon feedback about depth of penetration into posterior segment structures, the distribution and propagation of injected fluid, vector reflux, and the integrity of the fovea during the procedures.
- 1 Cincinnati Eye Institute, Cincinnati, OH, USA
- 2 University of Cincinnati, Department of Ophthalmology
- 3 Abrahamson Pediatric Eye Institute, Cincinnati Children’s Hospital Medical Center
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