Intraoperative OCT-Assisted Gene Therapy

Sisk, Robert A.

January 20, 2021

Intraoperative OCT-Assisted Gene Therapy

Intraoperative OCT Augments Surgical Safety and Accuracy of Treatment Delivery in Subretinal Gene Augmentation Therapy

Gene augmentation therapy is a method of ocular gene transfer for autosomal recessive or X-linked retinal dystrophies when there is insufficient functional protein manifesting as genetic disease. These genetic defects cause specific visual impairments and/or retinal degeneration. There has been a recent explosion in interest in gene therapy applications for retinal dystrophies. The surgical technique for subretinal injection of gene therapy is technically demanding and challenging. Intraoperative optical coherence tomography (Intraoperative OCT) provides real-time information and surgeon feedback about depth of penetration into posterior segment structures, the distribution and propagation of injected fluid, vector reflux, and the integrity of the fovea during the procedures.

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About Dr. Robert Sisk

Robert Sisk, MD is Associate Professor of Ophthalmology at the University of Cincinnati. He is a Vitreoretinal Surgeon and partner at Cincinnati Eye Institute and serves as Director of Pediatric Retinal Surgery and Director of Ophthalmic Genetics at Cincinnati Children’s Hospital. He completed a Vitreoretinal fellowship at Bascom Palmer Eye Institute after his Ophthalmology residency at University of Cincinnati. He is a principal investigator for numerous clinical trials with interests in gene and cell therapy, macular degeneration, and diabetic retinopathy.