Laser Microdissection LMD
Laser Microdissection, also known as LMD or LCM (Laser Capture Microdissection), is a contact- and contamination-free method for isolating specific single cells or entire areas of tissue from a wide variety of tissue samples. The thickness, texture and preparation technique of the original tissue are relatively unimportant. The dissectate is then available for further molecular biological methods such as PCR, real-time PCR, proteomics and other analytical techniques. Laser microdissection is now used in a large number of research fields, e.g. neurology, cancer research, plant analysis, forensics or climate research. The method is meanwhile also applied for manipulation of cell cultures or for microengraving of coverslips.
Our LMD Systems are perfect tools to optimize DNA-Workflows (Genomics), RNA-Workflows (Transcriptomics) and Proteomic-Workflows as they allow to precisely define and collect pure starting material for analysis under visual control.
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The Leica LMD process
Read our latest articles about Laser Microdissection
The knowledge portal of Leica Microsystems offers scientific research and teaching material on the subjects of microscopy. The content is designed to support beginners, experienced practitioners and scientists alike in their everyday work and experiments.
RNA Quality after Different Tissue Sample Preparation
Dissecting Proteomic Heterogeneity of the Tumor Microenvironment
20 Years of Leica Laser Microdissection
How to improve your Biomarker Discovery Workflow with Laser Microdissection
Microscopy in Virology
Improving RNA Analysis with Laser Microdissection
How to improve your Alzheimer Protein Analysis with Laser Microdissection
How to improve your DNA Mutation Analysis Workflow with Laser Microdissection
Live Cell Isolation by Laser Microdissection
Correlation of Phenotype and Genotype – microscopic samples and their biomolecular backgrounds
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